Parker Mathews's research while affiliated with Duke University Medical Center and other places

Publications (5)

Article
Many patients with multiple myeloma (MM) have comorbidities and are treated with PPAR agonists. Immunomodulatory agents (IMiDs) are the cornerstones for MM therapy. Currently, little is known about how co-administration of PPAR agonists impacts lenalidomide treatment in patients with MM. Here, we determined the effects of PPAR agonists on anti-myel...
Article
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The United States is undergoing a demographic shift towards an older population with profound economic, social, and healthcare implications. The number of Americans aged 65 and older will reach 80 million by 2040. The shift will be even more dramatic in the extremes of age, with a projected 400% increase in the population over 85 years old in the n...
Article
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We determined the impact of bone marrow fibrosis (BMF) on the clinical outcomes of newly diagnosed multiple myeloma (NDMM) patients in the current era of myeloma therapy. A total of 393 MM patients were included in the final analysis. The median followup was 83 months (range: 3.9 to 212 months). BMF was noted in 122 (48.2%) evaluable patients. Medi...
Article
Full-text available
A window to the embryo Mammalian embryonic development is a complex process, continuously changing in space and time. Q. Huang et al. designed an abdominal window to image mouse embryos in utero from embryonic day 9.5 to birth. Using this technique, they visualized dynamic activities during embryonic organ formation, including neurotransmission and...
Article
PURPOSE We performed a retrospective chart review on 393 patients with multiple myeloma (MM) to determine the utility of the gamma gap (GG). METHODS We calculated the difference between a patient’s total serum protein and albumin as a point-of-care test for assessing disease status in MM. RESULTS GG is highly correlated with the level of M-spike,...

Citations

... In patients with MM, increased bone marrow fibrosis (BMF) has also been reported as one of the factors that reduce the survival time (Subramanian et al. 2007). Patients with MM with BMF (especially those with extensive BMF) have a worse prognosis even when treated with immunomodulatory agents and proteasome inhibitors (Paul et al. 2020). Understanding the changes in the bone marrow microenvironment and the prognostic implications of these changes is of great importance to further improve the efficacy of myeloma treatment and outcomes for patients with MM. ...
... Noninvasive imaging of the developing embryo in vivo is highly desired for developmental and reproductive biology. Traditional high-resolution optical imaging, such as two-photon microscopy, cannot access the deep-seated embryos without implanting intravital windows 32 . We crossed the homozygous loxP-BphP1 male mouse with the homozygous Vasa-Cre female mouse and imaged the pregnant female mouse on E15 stage (Fig. 6a). ...
... e. Gamma Gap como estrategia alterna en urgencias: Por temas administrativos muchos laboratorios solo procesan electroforesis 1 ó 2 veces a la semana, en esencia la sospecha clínica de gammapatía monoclonal podría reforzarse en menos de 2 horas con la relación proteínas totales -Albúmina (Gamma GAP) > 4g/L sugiere una paraproteinemia, incluso un estudio de la universidad de Duke respalda el uso de la estrategia. En la experiencia de los autores ha servido para toma temprana de decisiones (26). ...