Pankaj Sahu’s research while affiliated with Rungta College of Pharmaceutical Sciences and Research and other places

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Publications (15)


Formulation and evaluation of colon specific matrix tablet of metronidazole
  • Article

May 2018

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51 Reads

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3 Citations

Research Journal of Pharmacy and Technology

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Tripti Banjare

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[...]

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D.K. Tripathi

Targeting of drug to the colon oral route the drug release is controlled by the gastrointestinal pH, transit times and intestinal flora. Metronidazole is only used antibiotics, which can be used, in colonic disease. Matrix formulations containing various proportions of Xanthan gum and HPMC E5LV were prepared by wet granulation technique using 10% starch paste. Six Matrix tablet formulation (1 to 6) of Metronidazole were prepared different mixture of Xanthan gum and HPMC-E5LV. All the formulations were evaluated for in-process quality control tests. The in-vitro drug release study first in 0.1N HCl followed by in pH 7.4 phosphate buffer, the formulation F3 show good drug release in control manner. Hence, synthetic polymer such as HPMCE5LV is most cheap and suitable for colonic drug delivery.


Formulation and evaluation of gastro retentive sustained release tablets of ziprasidone hydrochloride

May 2018

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117 Reads

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1 Citation

Research Journal of Pharmacy and Technology

Ziprasidone hydrochloride is a psychotropic agent. To reduce the frequency of administration and to improve patient compliance, a sustained-release formulation of Ziprasidone hydrochloride is desirable. The aim of the present work is to develop a hydrodynamically balanced drug delivery system based on the platform of direct compression. The system shall be designed to release at least 65% of the drug over a period of 8 hours and not less than 80% release in 12 hours. Sodium bicarbonate was incorporated as a gas-generating agent along with independent variables of natural resinhydroxy propyl methyl cellulose (HPMC) grade K4M and hydroxyl propyl methyl cellulose (HPMC) grade K100M at successfully prepared with hydrophilic polymers like HPMC K4M, HPMC K15M and HPMC K100M.to achieve sustained release effect. The drug-excipient compatibility was studied with the help of Infrared-red spectroscopy. Dissolution studies using the USP basket method were performed at 37±0.5ºC in 0.1N HCl and 2% SLS. Fourier transformer infrared spectroscopy (FTIR) was performed for the physicochemical interaction between drug and carrier, hence its effect on dissolution. It was observed that formulation containing 60% hydroxy propyl methyl cellulose (HPMC) grade K15M (F6) shows optimum sustained drug release pattern with adequate floating. Thus this technique can be successfully used for improvement of dissolution of ziprasidonehydrocholoride.


Formulation and evaluation of Self-Poring osmotic tablet of diltiazem HCl for the treatment of hypertension

May 2018

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83 Reads

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2 Citations

Research Journal of Pharmacy and Technology

With emergence of new technology and concept, self-poring osmotic tablets were developed in order to reduce the complications and problems associated with micro drilling and laser drilling in osmotic tablet. This research describes a very simple and cheap method of developing self-poring osmotic tablet that deliver DiltiazemHCl in a controlled rate for prolonged duration. For this purpose 5 formulations of osmotictablets were prepared through wet granulation technique in which different concentration of sodium lauryl sulphate (SLS) were used as pore forming agent in coating solution. In tablet core also varied concentration of sorbitol as osmogens, guar gum and HPMC were encorporated, which forms gel like matrix through which drug releases at zero order. Through optimization out of 5 formulations, F3 (C2) formulation was selected as best. From result of invitro drug release study it was clear that more concentration of pore former and osmogens releases drug in short time while less concentration takes more time for drug release. Therefore, it is necessary to use SLS, polymer and osmogens in balance concentration for getting optimum control release at zero order upto 24 hrs. Self-poring Osmotic tablets hold promising potential for increasing drug efficacy and reducing dosing frequency with minimal side effects also provides an economic means of developing controlled release dosage forms.


Formulation and Evaluation of Dispersible Tablet of Monteleukast Sodium

April 2018

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65 Reads

Research Journal of Pharmacy and Technology

Monteleukast sodium is most commonly used in treatment of Asthma. It mainly prevents leukotriene mediated effect associated with asthama. Dispersible tablet are film coated or uncoated tablet that can be dispersed in liquid medium before administration, giving a homogenous dispersion. Dispersible tablet were prepared by using a direct compression method employing super disintegrating agentsuch as cross povidone, cross carmellose sodium and sodium starch glycolate, the tablet were preparedusing various diluents like MCC and lactose. Magnesium stearate and talc is used as a lubricant and glidant. Pre-compression parameter such as angle of repose, bulk density, tapped density, carrs index, hausner ratio carried out to study the flow properties of powder to achieve uniformity of tablet. The prepared tablet were evaluated for hardness, thickness, weight variation friablitity, % drug content, disintegration time and other parameter such as wetting time were also evaluated.


Formulation and Evaluation of Ascorbic acid Lozenges for the treatment of Oral Ulcer

April 2018

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1,275 Reads

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8 Citations

Research Journal of Pharmacy and Technology

Inspite of several dosage forms available in the market for effective localized action, the lozenges finds a special importance, as they are the best dosage forms for formulating large dose medicaments. The anatomy of mouth and cheek favors easy absorption of drug, reducing the systemic absorption thus ensuring a better patient compliance especially for pediatrics and geriatrics. Ascorbic acid mechanism of action suites this type of formulation and easily absorbed in oral cavity. Preformulation studies are primarily done to investigate the physicochemical properties of drug and to establish its compatibility with other excipients. Ascorbic acid was mixed with all excipients, used in the formulation in different.The formulated lozenges were evaluated for physical parameters and the results complied with the pharmacopoeiallimits.ascorbic acid hard candy lozenges were prepared by heat fusion method using sugar as a base. The usage of corn syrup in the formulation made the lozenges transparent and smooth, which helped in improving the elegancy of formulation. The controlled release of medicament from Lozenges was achieved by using polymers like methyl cellulose, locust bean gum, HPMC, K4M and xanthan gum. The prepared lozenges were subjected to physico-chemical as well as in vitro drug release study. Among all the formulations of hard candy lozenges FL1 showed good stability.


Figure 1:-Comparative study in vitro dissolution profile ofdifferent formulation of Azithromycin oral reconstitutable suspense
Formulation and Evaluation of oral reconstitutable Azithromycin Suspension for the treatment of Bacterial Infection
  • Article
  • Full-text available

April 2018

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165 Reads

Research Journal of Pharmacy and Technology

Azithromycin is used for the treatment of bacterial infection, mainly used in middle ear infection, typhoid, sinusitis, bronchitis in urinary tract infection and venereal disease. The present study aimed to develop dry or oral reconstitutable suspension to minimize the solubility problem of the drug. It shows the adequate chemical stability of the drug during the shelf life and it avoids the problem of physical stability and solubility of drug. The study was carried out by preparing the dry powder or granules for oral reconstitutable suspension by using suspending agent sodium CMC and acacia on release profile of the drug. The prepared best formulation (F6) was selected depending on its physiochemical properties. The prepared oral reconstitutable suspension was evaluated for the rheological, viscosity, re-suspendibility and sedimentation volume. The formulation of acacia showed excellent sedimentation volume and good re-dispersibility as compared to other formulation. The study was found that the dry physical mixture method showed good stability of the drug.

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Citations (11)


... Currently, available marketed preparation of Risperidone is Solution, tablet, oral disintegrating tablet and powder for injection. 8,9 An attempt has been made to develop spray dried Poly lactide co-glycolide (PLGA) nanoparticles, 10 floating microparticles, 11 self-nanoemulsifying drug delivery system, 12 sustained release tablets, 13 fast dissolving film, 14 and chitosan nanoparticles. 15 Due to very fine particle size, Nanoparticles are considered as potential carrier for efficient drug delivery and can be administered by various routes. ...

Reference:

Effect of Formulation Variables on Fabrication of Risperidone Loaded Nanoparticles for Sustained Drug Delivery
Formulation and Evaluation of Risperidone Loaded Mouth-Dissolving Film
  • Citing Article
  • January 2018

Research Journal of Pharmacy and Technology

... Average weight of the tablets was calculated by dividing the total weight of all tablets over number tablets. Than weight variation range was established with a weight variation of ±7.5 mg [27] . ...

Formulation and Evaluation of directly compressed Floating Tablets of Candesartan Cilexetil for Gastro Retentive Drug Delivery
  • Citing Article
  • January 2018

Research Journal of Pharmacy and Technology

... Freeze Drying, Tablet Molding, Spray drying are the conventional technologies for fast dissolving tablet 19 . Few properties of fast dissolving tablets such as no bitter taste, dose lower than 20mg, small to moderate molecular weight, good stability in water and saliva 20,21 . Various superdisintegrant like Croscarmellose sodium (Ac-Di-Sol), crospovidone (CP), PolyplasdoneXL XL, sodium starch glycolate (SSG) can be used in formulation of fast dissolving tablets. ...

Development of lamotrigine solid dispersion for the formulation and evaluation of fast dissolving tablets
  • Citing Article
  • January 2018

Research Journal of Pharmacy and Technology

... Terminalia chebula fruits were dried out in shade and crushed to obtain a coarse powder. [3,4] The material was passed over a sieve and kept in a plate. Material of Terminalia chebula subjected to continuous Soxhlet extraction method to extract with methanol. ...

Formulation and evaluation of immediate release tablet of risperidone
  • Citing Article
  • January 2018

Research Journal of Pharmacy and Technology

... The tablet's friability was tested using a Roche friabilator (25 revolutions per minute for 4 minutes) and the content homogeneity was assessed as per the method outlined in the Indian Pharmacopoeia. 16,17 Determination of drug content in tablet formulations IRT core tablets were tested according to the tested method to determine the drug concentration. Following the dissolution of 100 mg of powder through 10 tablets in 50ml of methanol, we periodically sonicated the blend for 6 hours, ensuring full solubility. ...

Formulation and evaluation of colon specific matrix tablet of metronidazole
  • Citing Article
  • May 2018

Research Journal of Pharmacy and Technology

... Hal ini secara luas diakui sebagai faktor risiko independen utama untuk penyakit jantung koroner, gagal jantung, stroke, penyakit pembuluh darah perifer, gangguan kognitif, gangguan ginjal, dan gangguan penglihatan, dan memberikan beban ekonomi yang signifikan pada negara dan individu (Amin et al., 2020;Kwon & Ahn, 2018). Pada tahun 2025, diperkirakan jumlah penderita hipertensi akan meningkat sekitar 60%, menjadi total 1,56 miliar (Permata et al., 2021;Kearney et al., 2019;Thapa et al., 2018). ...

Formulation and evaluation of Self-Poring osmotic tablet of diltiazem HCl for the treatment of hypertension
  • Citing Article
  • May 2018

Research Journal of Pharmacy and Technology

... [8][9][10] Because of frequent relapses at short intervals, some physicians have used it for prolonged periods. 11,12 Sustain release mucoadhesive pill of itraconazole showed ratio of drug release up to 86% for 9 hours 13 . Previously local iodine had been used in treatment of tenia capitis. ...

Formulation and evaluation of Itraconazole mucoadhesive tablets for sustained release

Research Journal of Pharmacy and Technology

... Previous reports found that oral itraconazole is safe formulation. 29,30 The long intake duration of oral itraconzol and there is no group trail for topical 5% tincture of iodine alone, are the limitations of this work. ...

Formulation and evaluation of sustained released buccoadhesive tablets of Itraconazole
  • Citing Article
  • January 2018

Research Journal of Pharmacy and Technology

... It belongs to a group known as leukotriene receptor antagonists. It works by slowing the effects of leukotrienes, a material formed by the body in response to certain triggers that cause swelling and narrowing of airways in the lungs [12]. ...

Formulation and evaluation of orodispersible tablet of montelukast sodium
  • Citing Article
  • January 2018

Research Journal of Pharmacy and Technology