Pankaj Patel's research while affiliated with Smt. N.H.L. Municipal Medical College and other places

Publications (48)

Article
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Objectives To assess the effect of a mobile phone application for prehospital notification on resuscitation and patient outcomes. Design Longitudinal prospective cohort study with preintervention and postintervention cohorts. Setting Major trauma centre in India. Participants Injured patients being transported by ambulance and allocated to red (...
Article
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Phenytoin is aromatic amine which is a hydantoin derivative and used to be a first line anti-epileptic drug, but due to its frequent side effects is not used routinely now a days. Here in we reported Phenytoin induced Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome which is a serious Adverse Drug Reaction and concluded as pos...
Article
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Background: Emergency department (ED) being the most crucial part of hospital, where adverse drug reactions (ADRs) often go undetected. Trigger tools are proficient ADR detection methods, which have only been applied for retrospective surveillance. We did a prospective analysis to further refine the trigger tool application in healthcare settings....
Article
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Warfarin is an oral vitamin K antagonist prescribed to those patients for the treatment and prevention of thromboembolism. The major challenges to be faced during the therapy were a greater risk for both major as well as minor bleeding, which makes the regular monitoring of INR (international normalized ratio) mandatory. Herein, we reported a case...
Article
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Methotrexate (MTX) is the most widely used drug in clinical practice for long term treatment of connective tissue disorders. As this drug has narrow therapeutic index, if it goes unmonitored can lead to life threatening complications. Herein we are describing the case of a patient who presented with ventricular arrhythmia, due to failure to execute...
Article
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Background: Osteoporosis (OP) is a silently progressing metabolic bone disease that results in loss of mineralized bone and subsequent fractures with minor trauma. Fracture related pain and physical inability to perform activities of daily living can lead to psychological consequences that impair Quality of Life (QoF). However, much less is known a...
Article
Background The completeness of a trauma registry’s data is essential for its valid use. This study aimed to evaluate the extent of missing data in a new multicentre trauma registry in India and to assess the association between data completeness and potential predictors of missing data, particularly mortality. Methods The proportion of missing dat...
Article
Psychosis induced by antiepileptic drugs (AEDs) is considerably an iatrogenic adverse drug reaction. Various mechanisms operant in the development of iatrogenic psychiatric manifestations are proposed which necessitates analyzing complaints of psychiatric symptoms related to medication. Herein, we present a rare case of short-term use of phenytoin...
Article
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Oseltamivir was approved for the prevention and treatment of influenza in 1999 by the USFDA (US Food and Drug Administration). The use of Oseltamivir is increasing rapidly all over the world, especially after the 2009 “Swine Flu” pandemic. Less data is published as far as the cardiovascular side effects of Oseltamivir are concerned, but it could be...
Article
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Rituximab has a myriad of clinical uses, ranging from its disease modifying action in rheumatoid arthritis, to its role in chemotherapy for cancer. Being an anti CD20 monoclonal antibody, it controls inflammation by targeting peripheral B cells including those present in the synovium. The use of Rituximab is associated with some side effects such a...
Article
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Electrolytes imbalance has been reported with the use of several antimicrobials in clinical scenarios. Piperacillin/tazobactam is a commonly used antibiotic with tolerable side effects and broad antimicrobial activity in general practice. Herein we report a case of a 27 year old male presented with Road Traffic Accident with depressed frontal bone...
Article
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A 14 year MR (measles of bilateral lower limb weakness with difficulty in walking, visual hallucinations and suicidal ideas and eventually developed Psychosis after a week of his dose of MR vaccination. EEG, MRI MRI-Spine were normal. The diag triggered due to MR vaccine. Patient was started on Tab. Clonazepam but his condition was not improved and...
Article
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Background: Electrolytes play an important role in various physiological functions of the body. Electrolyte disturbances are one of the most common problems encountered in critically ill patients. Drugs are also known to cause adverse electrolyte consequences. These drugs could be anti-hypertensive agents, hormones, antipsychotics or steroids. Ther...
Article
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Rituximab is a genetically engineered chimeric murine/human monoclonal IgG1 kappa antibody directed against the CD20 antigen. It has been approved for rheumatoid arthritis and is a promising new agent in the treatment of several autoimmune neurological disorders and also Sjögren’s syndrome. Common adverse reactions to treatment with Rituximab inclu...
Article
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Health care workers are at increased risk of needle stick injuries. Blood borne diseases that could be transmitted by such an injury include HIV, Hepatitis B, HCV and many others. Post exposure prophylaxis should be immediately started within 72 hours and should be continued for 28 days. Currently two Nucleoside Reverse Transcriptase Inhibitors (NR...
Article
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Older patients suffering from depression and psychosis have markedly increased since last decade. So, has the use of antidepressants and antipsychotics. The prevalence of hyponatremia due to these drugs is common in general as well as psychiatric practice. It may also lead to life threatening morbidity and mortality. Loss of renal function, polypha...
Article
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Stevens-Johnson syndrome (SJS) is an Ig E mediated hypersensitivity reaction, sometimes complicated by ocular manifestations. Antiepileptics induced SJS is common with Carbamazepine. Phenobarbitone is known to cause hypersensitivity reactions like mild to moderate rashes but not life-threatening reactions like SJS. We present a case report of an 18...
Article
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Drug Therapeutic failure is a rare condition which is underreported in recent scenario. It is important for the chronic diseases like Hypertension where it could lead to fatal outcome. In our case report elderly male patient taking tablet Amlodipine once daily as antihypertensive medication and had 2 years without any events. Patient came to the em...
Article
Medication errors may produce severe toxicity resulting in hospitalization. This can be compounded if the physician obtains the wrong concentration from a reference manual and a pharmacy miscalculates the conversion. We present a case report of phenytoin toxicity related to overdose in 19 year girl which is related to prescribing error and dose rel...
Article
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Topical corticosteroids prescribed for various dermatological conditions, if used haphazardly have their adverse effects too, like aggravation of underlying infections - tinea, herpes etc. Tinea incognito is a fungal infection of skin masked and often exacerbated by application of topical immunosuppressive or steroid agent. Tinea incognito results...
Article
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Aneurysmal Bone Cyst (ABCs) is a cystic expansile lesion which is usually found in solitary locations in the metaphysis of long bones. The most common locations of ABC are long bones of lower limbs. There is little knowledge about the presence of this tumor in Clavicle. Here we present a case of a six year old male child who presented with complain...
Article
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Introduction Prehospital notification of injured patients enables prompt and timely care in hospital through adequate preparation of trauma teams, space, equipment and consumables necessary for resuscitation, and may improve outcomes. In India, anecdotal reports suggest that prehospital notification, in those few places where it occurs, is unstruct...
Conference Paper
Introduction: None of the existing studies have compared the results of open and Micro Endoscopic Discectomy (MED) surgeries in labourers. The aim of this study was to compare the clinical and social impact of open versus MED surgery in labourers . Methods: Retrospective review analysis was performed in 70 labourers (40 males and 30 females) who un...
Article
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Erythema Multiforme (EM) is a skin condition having various aetiologies including drugs. Pyrazinamide, one of the 1st line Antitubercular drugs (AKT) is known to cause various adverse effects. However, reports of Pyrazinamide induced EM are rare. In the below mentioned case, the patient had presented to Dermatology Department with skin lesions afte...
Article
Full-text available
Aneurysmal Bone Cyst (ABCs) is a cystic expansile lesion which is usually found in solitary locations in the metaphysis of long bones. The most common locations of ABC are long bones of lower limbs. There is little knowledge about the presence of this tumor in Clavicle. Here we present a case of a six year old male child who presented with complain...
Article
Full-text available
This is a report of four cases of possible suicidal ideation with the use of antidepressants in Indian population. The patients presented to emergency department of a tertiary care hospital with attempted suicide. All of them were prescribed at least one antidepressant. The association of increased suicidal attempts/ideation with antidepressant dru...
Article
Benzathine penicillin is the drug of choice for prophylaxis in rheumatic heart disease. It is given intramuscularly, every 21-30 days after test dose and gives excellent results. But it has the side effects of hypersensitivity and fatal anaphylactic reaction even when patient had received it in past since long without any problem. Fatal anaphylaxis...
Conference Paper
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Purpose of Study: None of study reviewed on socio-economic impact after cervical spine surgery in patients with cervical spine injury or myelopathy. Aim was to study clinico-radiological results and socio-economic impact even after radiologically successful surgery. Methods: After board approval, 104 participants (56 traumatic, 48 myelopathy) were...
Article
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Introduction: In the recent era of trauma, about one million people get seriously injured annually. Majority of them suffer from lower limb injuries. Due to lack of trauma registry in India, prediction models are not much effective. The aim of our study was to derive basic epidemiological parameters for lower limb injuries which can be used to deve...
Article
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Elbow trauma is challenging to manage by virtue of its complex articular structure and capsuloligamentous and musculotendinous arrangements. We included 17 patients with elbow dislocation and associated injuries in this study. The study protocol included early elbow reduction and planned fixation of the medial or lateral condyle, coronoid and radia...
Article
Proximal humeral fractures account for 4-5% of all fractures; most of them involving elderly and osteoporo- tic people.(1) Many treatment options are available like conservative treatment, open reduction internal fixa- tion, joint replacement, and percutaneous fixation. This is a comparative study of 11 paired patients (n=22) having proximal humeru...
Article
The goal of fusion of the lumbar spine is to obtain primary solid arthrodesis thus to alleviate pain. The TLIF procedure has rapidly gained popularity; because of its posterolateral extracanalar discectomy and fusion, it has been reported as a safe technique, without the potential complications.(1) A retrospective clinical and radiographic study of...
Article
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Magnetic resonance myelography (MRM) after lumbar discectomy is all too often an unrewarding challenge. A constellation of findings are inevitable, and determining their significance is often difficult. MRM is a noninvasive technique that can provide anatomical information about the subarachnoid space. Until now, there is no study reported in liter...
Article
Study designProspective. ObjectiveTo assess the results of laminectomy in patients suffering from multilevel multidirectional compressive cervical myelopathy with co-morbid conditions and to compare results of anterior and laminectomy clinically, radiologically and functionally. Summary of background dataCervical myelopathy or myeloradiculopathy...
Article
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The treatment of intra-articular proximal tibial fractures is associated with complications, and much conflicting literature exists concerning the treatment of choice. In our study, an attempt has been made to develop an ideal and adequate treatment protocol for these intra-articular fractures. The principle of double osteosynthesis, i.e., lateral...
Article
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Clubfoot is the commonest congenital deformity in babies. More than 100,000 babies are born worldwide each year with congenital clubfoot. Around 80% of the cases occur in developing nations. We treated 154 feet [mean Pirani score (total) 5.57] in 96 children (78 males, 18 females) by the Ponseti method from January 2003 to December 2005. A prospect...

Citations

... The need for more effective way to identify events to the "trigger tool", a method used to detect potential adverse drug events developed by the US Institute The US Institute for Healthcare Improvement (IHI) (16) . According to Pierdevara et al. (13) , in order to make the method less expensive and more applicable to the practice, IHI developed IHI Global Trigger Tool (GTT) methodology, in the 2000s. ...
... We made a table with some of the previous reports of PHT intoxication presenting with acute psychosis [ Table 1]. [1][2][3][4][5] In the studies of Table 1, all the individuals had full recovery after PHT withdrawal. This could be explained by the short-term use of medication. ...
... However, severe anaphylaxis has been reported with the use of TCZ. [31] TCZ is known to increase the levels of serum total cholesterol, LDL, and triglycerides and the same have been observed in this study. [32] The patients on TCZ therapy should undergo periodic monitoring of serum lipid levels. ...
... Investigations of ECG changes associated with methotrexate are limited. Methotrexate was reported to induce ventricular arrhythmia 17,18 On the other hand, LIR was found to increase heart rate in type 2 diabetic patients as a compensatory Results were expressed as mean ± SD, (n=8). a p< 0.05 as compared to the control group. ...
... Therefore, since the development and establishment of a DVRS, with respect to public health approach, is a relatively new and novel initiative, we reviewed other similar studies in the field of wound, trauma, or injury registry systems. These examples used different approaches to develop and/or validate the registry systems such as interphysician reliability assessment [23], registration of injured patients by a registrar for analysis [24], evaluation of data completeness [25], and exploring the problems of the registry system with regards to data entry, errors, and data collation [26]. Moreover, even these studies did not use a systematic approach to development and validation of the registry datasheets in an step-by-step process. ...
... The treatment dosage regimens were 75 mg twice daily for patients with creatinine clearance > 60 mL/min, and a lower dosage for those with a lower creatinine clearance [14]. An association between bradycardia and oseltamivir use has been reported in case reports in both pediatric [15,16] and adult patients [17,18]. ...
... On the other hand, the case reports and national registries indicate that TB infection is also possible using RTX. 8,[16][17][18] Three cases of active TB were reported in a survey conducted by the Emerging Infections Network. 19 A 42-year-old woman with RA developed knee TB arthritis while receiving RTX. ...
... It is the most widely prescribed antibiotic agent for moderate-to-severe infections owing to its broad-spectrum activity [3][4][5] and the option of carbapenem-sparing treatment [6]. TZP is considered a safe drug [4], but TZP-associated electrolyte disorders (EDs), including serious cases, have been widely reported [7][8][9][10][11][12][13][14][15][16][17]. Hypokalemia is the most frequently reported ED [7][8][9][10][11][12][13][14][15][16] with an inconsistent incidence, ranging from less than 1% to 24.8% [5,[7][8][9]. ...
... 17,18 Second-generation antipsychotics are associated with electrolyte disturbances such as hyponatraemia and hypokalaemia, although the mechanism remains unclear. [19][20][21][22] Along with (female) sex and age, other factors such as bradycardia, alcohol intake and illicit substance use are risk factors for a prolonged QT interval. 23,24 There are two main limitations for accurately measuring the QT interval and assessing the risk of complications in clinical practice. ...
... Many elderly people are especially vulnerable to hyponatremia as they will be on diuretics. Loss of kidney function, polypharmacy, dementia, and other advanced-age disorders can increase the severity of hyponatremia [4]. Also, the conditions that increase water intake, such as delusional states, obsessive-compulsive behavior, and dry mouth associated with the anticholinergic side effects of many psychiatric medicines, are potential risk factors for the development of hyponatremia in psychiatric patients. ...