Pankaj Khatri’s research while affiliated with gyan vihar school of pharmacy and other places

India has a rich culture of medicinal herbs and spices, including Ayurvedic, Unani, Siddha and other traditional medicines but only very few have been studied chemically and pharmacologically for their potential medicinal value. According to the World Health Organization, most populations still rely on traditional medicines for their psychological and physical health requirements. Herbal medicines are in great demand in both developed and developing countries as a source of primary health care owing to their attributes having wide biological and medicinal activities, high safety margins and lesser costs. As far as population growth is concerned India will be the leading country within few years of time span. Current pandemic population explosion demands an immediate betterment of new potential contraception.Thus, there is growing need to look for aphrodisiac more from natural plant or herbal origin as opposed to synthetic compounds which are known to cause severe unwanted side effects. In this regard, we have taken the plants Mucuna prurita, Mesua ferrea, punica granatum that has been used traditionally as antifertility agent in women and aphrodisiac, so that the couples without issue may be benefited for better acceptance in society and they may have better psychological health. In these plants so many secondary metabolites are present i.e carbohydrates, glycocides, alkaloids, tannins, phytosterol etc.All these three plants have pharmacological activity like Astringent, anthelimentic, nervine tonic, aphrodisiac, diuretic,

The Present investigation was undertaken to evaluate the Polyherbal Formulation of Lawsonia inermis and Azadirachta indica in Alloxan & Streptozocin induced diabetic rats. In Alloxan induced diabetic studies samples were collected at 0, 2nd, 5th, 7th and 10th day after the rats had undervent the hyperglycaemic condition. The results showed that the Polyherbal formulation of Lawsonia inermis and Azadirachta indica (F1, F2, F3) found to be significant decrease (P<0.01) in blood glucose level as compared to the diabetic control group of animals while F4 & F5 were not significant (P>0.01) compared to the diabetic control group of animals. Streptozocin induced diabetic studies evaluates the Blood glucose level and the Diabetic body weight parameters over a period of fourteen days after treatment with Polyherbal Formulation of Lawsonia inermis and Azadirachta indica. On the day 21 the animals treated with Glimiperide drug (1mg/Kg), F1, F2, F3, F4, F5 were observed with significant increase in their body weight as compared to Diabetic control group of animals and also showed significant decrease (P<0.01) in Blood glucose level compared to the Diabetic control group. KEY WORDS: Diabetes, Lawsonia inermis, Azadirachta indica, Streptozocin, Alloxan

Diabetic neuropathies are a family of nerve disorders caused by diabetes. Symptoms of the disease include nerve palsy, mononeuropathy, mononeuropathy multiplex, diabetic amyotrophy, painful polyneuropathy, autonomic neuropathy, and thoracoabdominal neuropathy. In this study, type 2 diabetes in rats was induced with nicotinamide-streptozotocin. Drug treatment was initiated on the d 15, with the combination regimen of metformin, pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin, amitriptyline and sitagliptin and led to significantly improved glycemic control, increased grip strength and paw jumping response on d 21, 28 and 35 (P < 0.001). Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21, 28 and 35 (P < 0.001). Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells, while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain. In conclusion, treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain, but causes an increase in grip strength and pain sensitivity, exhibits neural protection, and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes.

Diabetic neuropathies are a family of nerve disorders caused by diabetes. Symptoms of the disease include nerve palsy, mononeuropathy, mononeuropathy multiplex, diabetic amyotrophy, painful polyneuropathy, autonomic neu-ropathy, and thoracoabdominal neuropathy. In this study, type 2 diabetes in rats was induced with nicotinamide-streptozotocin. Drug treatment initiated on the 15 day, with metformin + pioglitazone + glimipiride, metformin + th sitagliptin, sitagliptin + amitriptyline and sitagliptin, led to significantly improved glycemic control, increased grip strength and paw jumping response on days 21, 28 and 35 (P < 0.001). Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different protocols on days 21, 28 and 35 (P < 0.001). Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells, while administration of metformin + sitagliptin showed tissue regeneration and no weight gain. In conclusion, treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no weight gain, an increase in grip strength and pain sensitivity, exhibits neural protection, and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes.

Pongamia pinnata belonging to the family Fabaceae (Papilionaceae) commonly known as Karanj. It is a small evergreen tree, which is widely distributed in India, Bangladesh, China, and Australia. The plants have been described as a useful remedy for foul ulcer, fistulous sores, gonorrhea and urethritis. The current review aims to describe the pharmacognostic descriptions and phytochemical potential of plant. Important phytoconstituents which had been reported consists of various flavonoid derivatives such as pongamones A-E in stem. Whereas flavonoids ponaganones had been isolated from root bark of Pongamia pinnata. Karangin, pongamol, pongagalabrone, pongapin, pinnatin and Kanjone have been isolated and characterized from seeds of Pongamia pinnata. The review also collaborates the pharmacological activities such as hypoglycemic, anti-dyslipidemic, antibacterial, anti-inflammatory, anti-diarrhoeal activity etc which had been recently elaborated by various research scientist around the globe.

Hepatic disease (Liver disease) is a term for a collection of conditions, diseases, and infections that affect the cells, tissues, structures, or functions of the liver. Liver has a wide range of functions, including detoxification, protein synthesis, and production of biochemical necessary for digestion and synthesis as well as breakdown of small and complex molecules, many of which are necessary for normal vital functions. There are no specific allopathic medicines uses as hepatoprotective, although different research works are going on some drug. Herbal drugs are more widely used than allopathic drugs as hepatoprotectives because of them are inexpensive, better cultural acceptability, better compatibility, with the human body and minimal side effects. In the current review, it had been tried to redefine the use of important herbal hepatoprotective drugs like Silybum marianum, Andrographis paniculata and Swertia Chirata that consist of specific chemical constituents who have their specific hepatoprotective activity against hepatotoxicant like ethanol, drugs, chemicals and others. These herbal drugs have shown the ability to maintain the normal functional statues of the liver with or without fewer side effects. These are the reason that's why herbal hepatoprotectives are mostly preferred by medical practitioners, as well as over-the-counter. INTRODUCTION Hepatic Disease Hepatic disease (Liver disease) is a term for a collection of conditions, diseases, and infections that affect the cells, tissues, structures, or functions of the liver and can be defined as an alanine aminotranferase (ALT)/ SGPT level of more than three times the upper limit of the normal range, an alkaline phosphatases (ALP) level of more than twice the upper limit of normal, or a total bilirubin level (TBL) of more than twice the upper limit of normal if associated with any elevation of the alanine aminotransferase or alkaline phosphatase level 1 .

Summary Rheumatoid arthritis is a chronic, systemic, inflammatory autoimmune disorder causing symmetrical polyarthritis of large and small joints, typically presenting between the ages of 30 and 50 years. The objective of the study was to investigate the anti arthritic activity of the ethanolic extract of Sida tiagii Bhandari seeds against experimental animal model of complete Freund's adjuvant (CFA) induced arthritis. Arthritis was induced in female Sprague Dawley (SD) rats by administration of complete Freund's adjuvant in the sub plantar region of the hind paw. Indomethacin (2 mg/kg/day p.o.) was used as the standard drug. Ethanolic extract of Sida tiagii was administered at the following doses 30, 100 and 300 mg/kg/day p.o. The treatments were started on the day of CFA administration. The change in body weight, paw volume, diameter of the tibiotarsal joint and leukocyte count in the blood were measured at different time points. The results demonstrate that ethanolic extract of Sida tiagii Bhandari dose dependently showed significant anti-arthritic activity with minimal side effect. As no gastric ulcer was seen in the animals treated with the extracts.

To prepare niosomes containing rifampicin were prepared using various nonionic surfactants of sorbitan ester class and cholesterol in 50:60 (1:1.2) percent mol fraction ratios for sustain release. To improve the dissolution rate of noisome are prepare handshaking method using Surfactants and cholesterol (150 μmol) in 50:60 (1:1.2) percent mol fraction ratio. The percent of drug estimated to be entrapped was noted to decrease progressively for various sorbitan esters used in the order of Span-85>Span-80>Span-60>Span-40>Span-20. In vitro release rate studies revealed that the cumulative percent rifampicin released was maximum for Span-20-based niosomes and minimum for Span-85-based niosomes. The handshaking method is a simple and efficient technique for designing functional niosomes for hydrophobic or amphiphilic drugs.