Pandey Shivanand's research while affiliated with Manipal Academy of Higher Education and other places

Publications (25)

Article
Full-text available
Cancer is a malignant disease that is characterized by rapid and uncontrolled formation of abnormal cells which may mass together to form a growth or tumor, or proliferate throughout the body. Next to heart disease, cancer is a major killer of mankind. This study aims at a preliminary phytochemical screening and anticancer evaluation of Adiantum ve...
Article
Full-text available
Basic goals in the development of taste masked orally disintegrating tablets are to increase patient compliance, ease of administration, safety and appropriate dosing. Orally disintegrating formulations also provide benefits for pharmaceutical companies like lifecycle management, line extension, market expansion, cost effective drug development pro...
Article
Undifferentiated cell capable of self-renewal and differentiate into more specialized cells. They have a unique ability to give rise to many different cell types such as skin, liver, kidney, heart, neuron or other organ cells. Therefore also called "body's master cells". Since diabetes is a disease with a major deficiency in the functioning of one...
Article
The aim of present study was development of simple, rapid and accurate HPTLC method for estimation of Protocatechuic acid in various extracts of Amumum subulatum Roxb. fruit constituents (Family Zingiberacea), commonly known as 'Badi Elaichi' or Greater Cardamom. The powdered drug was subjected to extraction by soxhlet apparatus using methanol and...
Article
There are four important applications of rDNA in the areas of human diseases prophylaxis, therapy, diagnosis and discovery. Areas of prophylaxis include vaccines and coagulation. It is now possible, through rDNA technology, to produce an effective and safer production of both live and killed vaccines with increase response and high specificity. Rec...
Article
Osmotic systems utilize the principle of osmotic pressure for the delivery of drugs. Drug release from these systems is independent of pH and other physiological parameter to a large extent and it is possible to modulate the release characteristic by optimizing the properties of drug and system 3, 4. Pressure generated by the osmotic flow of water...
Article
Herbal cosmetic also known as "natural cosmetics". With the beginning of the civilization, mankind had the magnetic dip towards impressing others with their looks. At the time, there were no fancy fairness creams or any cosmetic surgeries.1 The only thing they had was the knowledge of nature, compiled in the ayurveda. With the science of ayurveda,...
Article
A series of methyl 2-substituted benzimidazole-1-carbodithioates were successfully synthesized. Benzimidazoles were prepared by condensation of o-phenylenediamine with substituted Carboxylic acid and by condensation of substituted benzaldehyde, Sodium metabisulphate and o-phenylenediamine. Methyl Carbodithioate derivative of the benzimidazole were...
Article
The series of seven substituted 2-phenyl-benzothiazole and substituted 1, 3-benzothiazole-2-yl-4-carbothiaote derivatives were synthesized. Substituted 2-phenyl-benzothiazole were synthesised by condensing substituted benzoic acid with 2-amino thiophenol in the presence of phosphoric acid and 3-benzothiazole-2-yl-4-substituted carbothiaote derivati...
Article
Phytomedicines, complex chemical mixtures prepared from plants, have been used for health maintenance since ancient times. But many phytomedicines are limited in their effectiveness because they are poorly absorbed when taken by mouth. The PHYTOSOMETM technology, developed by Indena S.p.A. of Italy, markedly enhances the bioavailability of select p...
Article
A series of methyl 2-substituted benzimidazole-1-carbodithioates were successfully synthesized. Benzimidazoles was prepare by condensation of o-phenylenediamine with substituted Carboxylic acid and by condensation of substituted benzaldehyde, Sodium metabisulphate and o-phenylenediamine. Methyl Carbodithioate derivative of the benzimidazole were pr...
Article
The gastrointestinal tract (GIT) is the route of choice for the administration of most drugs, regardless of their molecular structure or weight. The manufacture of an oral dosage form does not have to meet specialized regulatory requirements relating to such issues as sterility, pyrogenicity, and particulate contamination. Insulin has an important...
Article
Full-text available
Mucoadhesive microspheres include microparticles and microcapsules (having a core of the drug) of 1-1000μm in diameter and consisting either entirely of a mucoadhesive polymer or having an outer coating of it, respectively. Amoxicillin microspheres were formulated by using solvent evaporation technique. Using Eudragit RS 100 as matrix polymer. Eval...
Article
The pulmonary route of administration offers several advantages. First, the lung has a large surface area for drug absorption, ranging from 100 to 140 m2. In addition, the alveolar epithelium has permeability that allows for rapid absorption of solutes. Because the mucociliary clearance of the alveolar lung tissue is slower than that of the bronchi...
Article
Microneedle-based vaccination with the current anthrax vaccine produced an equally effective immune response to intramuscular injection in rabbits using smaller dosage say researcher from Maryland and North Carolina. In the study researchers compared the efficacy of immunizing rabbits with the current anthrax vaccine intradermally using a microneed...
Article
Oral delivery is the most convenient and the most acceptable route. However, insulin by itself is degraded by intestinal enzymes and is not absorbed intact across the gastrointestinal mucosa. Now, a day gelatin, trypsin coated capsule, pill, pellets may be available. It has some disadvantages; a lot of the insulin will be wasted before it gets wher...
Article
Advances in the processing of materials on a micro-scale have led to the development and introduction of devices that employ very small needles. That has significant potential in devices for diagnostics, healthcare monitoring and drug delivery by mechanically perforating the outer skin layer and allowing for transdermal drug absorption or fluid sam...
Article
Various herbal drugs individually or in combination have been recommended for the treatment of different disease. The C.congesta commonly known as "karanda" has been recognized in different system of traditional medicine to cure various diseases. It contains several phytochemical constituents belonging to terpenoids category. The root is attributed...
Article
Advancements in the development of ultra-fine drug molecules and peptides suitable for pulmonary delivery have created the requirement for novel handling, metering and drug dispensing techniques; while circumventing the problem of agglomeration (usually solved by mixing the active drug formula with Excipient. Inhalation has long been established in...
Article
Inhalers are designed to disperse fine, respirable powders in a reproducible fashion for optimal systemic or local lung delivery. Together with our particle technologies, they create an integrated pulmonary delivery system. We also offer expertise in systems integration of pulmonary therapeutics with Metered Dose Inhalers (MDIs), including stable f...
Article
Drug delivery to the lungs by inhalation has attracted tremendous scientific and biomedical interest in recent years. This trend accompanies a rise in respiratory illnesses, dramatized by an increase in asthma population in the United States of 46% between 1982 and 1993 (Centers for Disease Control and Prevention, Atlanta, GA). Of at least equal im...
Article
Asthma is a pulmonary disease characterized by reversible airway obstruction, airway inflammation, and increased airway responsiveness to a variety of stimuli. Pulmonary delivery of drugs plays an indispensable role in the management of asthma. ß Adrenoceptor agonists and corticosteroids are two common classes of drugs administered via the lungs. P...
Article
Microneedles find widespread use; researchers must perfect the techniques for optimally inserting them into the skin, and complete the integration of microneedles into a full diagnostic, monitoring or drug delivery system. Microneedles are expected to be less painful than conventional hypodermic needles because they are too small to significantly s...
Article
Normally herbal products are free from side effects, adverse effects and they are low cost medicines, which will be beneficial for the people of many countries. Keeping this in view the plant Cedrus deodara wood was selected 1, 2, 3, 4 . This plant is one of the traditional medicinal plants used for fever, pulmonary complaints, urinary disorders, l...
Article
Variations in the physico-chemical properties of ketoconazole have been studied, following polymorphic changes caused by fusion-cooling processes or by recrystallization in solvents commonly used in the pharmaceutical industry. Changes in physico-chemical properties were measured by differential scanning calorimetry (DSC), infrared, X-rays and HPLC...

Citations

... The purpose of this study is to assess the effect of skin pretreatment with a microneedle roller on the local and transdermal delivery of DCF from a commercially available gel (Voltaren Õ ) and from a commercially available iontophoretic patch filled with a DCF solution. Microneedle rollers were introduced on the market mainly for use in cosmetics 12 . Indeed, the micro-damage to the skin produced by the microneedle rollers can possibly increase collagen production during the physiological repair process and thus improves the overall appearance of the skin. ...
... The microspheres were periodically removed, blotted with filter paper and their changes in weights were measured during the swelling until equilibration was attained. Finally, the weight of the swollen microspheres was recorded after a period of 3 hours, and the swelling ratio (SR) was then calculated from the formula (Shivanand et al., 2010). ...
... 25 Synthesis of 2-substituted benzimidazoles from ortho-phenylenediamine [2(k-x),2i,2g] 2-substituted benzimidazoles were synthesized by the reaction of o-phenylenediamine and substituted benzaldehyde by the procedure reported in literature. [26][27][28] Synthesis of mannich base of 2-substituted benzimidazoles with benzamide [3(a-x)] 2-substituted benzimidazole (0.01 mole) was added to the ethanolic solution of benzamide (0.01mole). Formaldehyde (37%) (0.01 mole) was added and the reaction mixture was then adjusted to the pH of 3.5 with conc. ...
... The device has two chambers, the first contains the delivery orifice and drug, and the second contains the osmotic engine. [34] A wax like layer separates the two chamber. To assemble the delivery device, the drug substance is placed in one of the chamber with a manual or automatic filling mechanism. ...
... The karanda was initial fruite in the Philippines in 1915. 5 Fruits are rich source of iron and vitamin C, therefore, ethnomedical the fruits are used for curing anemia, as an astringent, antiscorbutic, and as a remedy for biliousness. Its leaf decoction is used in contradiction of fever, diarrhea, and earache, whereas roots help as a stomachic, vermifuge, remedy for itches, and insect repellent. ...
... The word "psychosis" applies to a range of psychiatric illnesses but the term antipsychotic medications widely used for the treatment of schizophrenia -one of the more prevalent and weakening causes of florid-mental conditionalso known as neuroleptic medicines, antischizophrenia medicines or big tranquilizers [16][17][18]. They are characterized pharmacologically as antagonists of a dopamine receptor, but many still function with other targets, in particular 5hydroxytryptamine receptors (5-HT) [19][20][21][22][23]. ...
... Herbs do not produce instant cures. They offer a way to put the body in proper tune with nature [3]. The demand of herbal medicines is increasing rapidly due to their skin compatibility and lack of side effects. ...
... The weight was removed after 2 minutes and the diameter of the gel spreaded onglass slide was measured. The test was performed in triplicates for the gels containing 0.5, 0.75 and 1% carbopol concentrations [36][37][38]. ...
... Кроме того, ткани глаз гораздо менее чувствительны к развитию иммунологических реакций. Побочных эффектов не наблюдалось при долговременном ежедневном применении (до 3 месяцев) [52]. ...
... Genetic manipulations have taken the place of traditional techniques and have the huge potential to defeat such challenges [1]. There are applications of rDNA technology in almost every field from the medical industry to the food industry [20]. ...