P.-Y. Yan’s scientific contributions

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Publications (1)

Figure 1. The molecular structure of six compounds. The six compounds belong to polyphenols, among which QC3GP, QC3X, QC3G, QC and MC belong to flavonoids.
Figure 2. The stability of insulin resistance in cells was investigated by measuring glucose uptake. A, Study on the stability of 24 h after insulin stimulation. B, Study on the stability of 48 h after insulin stimulation. C, Study on the stability of 72 h after insulin stimulation. Cells viability of compounds were measured using CCK-8 ki. D, 1 μmol·L -1 Toxicological examination of compounds. E, 10 μmol·L -1 Toxicological examination of compounds. F, 100 μmol·L -1 Toxicological examination of compounds. Results are shown as mean x -± SD. **p < 0.01.*p < 0.05.
Figure 3. The lipid metabolism of insulin resistance in cells was investigated. A, Study was observed by oil red O staining on the the effect of 3T3-L1 adipocytes under different compounds (100×). B, Study on the improvement of glucose uptake in IR by Potentilla bifurca compounds. C, Study on the improvement of TG content in IR by Potentilla bifurca compounds. D, Study on the improvement of IL-6 content in IR by Potentilla bifurca compounds; Results are shown as mean x -± SD. **p < 0.01.*p < 0.05.
Figure 4. The expression of major proteins in PI3K/AKT signal pathway. A, B, Results of related protein expression, the data were determined by Western blotting. C, Study on the improvement of pAKT/AKT in IR by Potentilla bifurca compounds. D, Study on the improvement of IKKβ in IR by Potentilla bifurca compounds. E, Study on the improvement of p-NF-κBp65/ NF-κBp65 in IR by Potentilla bifurca compounds. Results are shown as mean x -± SD. **p < 0.01.*p < 0.05.
Potentilla bifurca flavonoids effectively improve insulin resistance
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November 2022

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43 Reads

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4 Citations

G.-Y. Wang

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P.-Y. Yan

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W Liu

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Y Zeng

Objective: The goal of this paper is to investigate the use of Potentilla bifurca in the treatment of type 2 diabetes. Materials and methods: We analyzed the improvement effect of 3T3-L1 adipocytes under insulin resistance (IR) with the compounds of Potentilla bifurca. Results: The Potentilla bifurca can significantly improve the glycolipid metabolism disorder in 3T3-L1 adipocytes (the effect of MC compounds is very significant). It can improve insulin resistance by enhancing the glucose uptake of 3T3-L1 adipocytes, decreasing IL-6 content, and regulating the content of p-Akt/Akt, IKKβ, and p-NF-κBp65/NF-κBp65 in the IRS/PI3K/Akt signaling pathway. Conclusions: Studies have shown that Potentilla bifurca has the ability to regulate glucolipid metabolism and can be used in the treatment of type 2 diabetes.

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Citations (1)

... Potentilla bifurca is a medicinal plant, and the root extracts have been applied for the treatment of certain viral infections as folk medicinal herbs (Yi et al., 2021). It is used in the treatment of type 2 diabetes (Wang et al., 2022). Potentilla bifurca has the strongest antioxidant activity (IC 50 value was 1.07±0.07 ...

Reference:

Mongolian Journal of Biological Sciences MJBS Antimicrobial Activity of Some Mongolian Plants
Potentilla bifurca flavonoids effectively improve insulin resistance
G.-Y. Wang

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P.-Y. Yan

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W Liu

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[...]

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Y Zeng