P Johnson's research while affiliated with Imperial College London and other places

... net), an electrical circuit simulator. It is illustrated in Fig. 2 (Pennati et al. 1997;Pennati and Fumero 2000), but we recalibrated it such that our FE and lumped parameter modeling for fetal Case 1 (32 WG) will match more recent invasive human fetal LV pressure measurements (Johnson et al. 2000), and descending aorta pulse pressure data (Versmold et al. 1981). The recalibration was achieved by scaling all resistances with a resistance scale factor, and all compliances with a compliance scale factor. ...

... Over 60% of first trimester miscarriages have an abnormal karyotype involving autosomal aneuploidies, thereby indicating aneuploidy as the major reason for pregnancy loss. 1 Although high levels of aneuploidy are seen in human spontaneous abortions, very few autosomal aneuploidies in the form of trisomies survive to birth. Autosomal trisomy refers to a condition where there is an extra copy of a particular autosome in the karyotype, resulting in three copies instead of the normal two copies. ...

... Minimum of 50 cells was analysed and about five representative images were captured for each sample. 20 ...

... 21 who proposed a methodology for allometric scaling of the lumped parameter from 38 weeks gestational age (GA) to other GA, as briefly explained in supplementary section S1 (which includes Table S1). However, we recalibrated it to fit more recent human fetal clinical measurements, 10,34 in contrast to some of its original fit to fetal lamb measurements. To do this, all resistances were scaled by an age-dependent factor, while all compliances were scaled by another. ...

... From the eighth week onward, male and female developmental pathways diverge. In males, maternal chorionic gonadotropins from the placenta stimulate growth and development of the testicular Leydig cells, which eventually produce their own testosterone for further development (3). The development of the external genitalia in males is dependent on the conversion of testosterone to the active component dihydrotestosterone (DHT). ...

... Birth weight less than the third percentile on a population-based or customized growth chart (86%) or at least 3 out of 5 of the following: Birthweight <10 th percentile on population-based (78%) or customized growth charts (94%) Head circumference <10 th percentile (82%) Length <10 th percentile (82%) Prenatal diagnosis of fetal growth restriction (88%) Maternal pregnancy information (e.g., hypertension or pre-eclampsia) (75%) relatively normal head size in a fetus that is otherwise growth restricted. [34][35][36][37] Typically, in the early placental insufficiency syndrome, fetuses are easily diagnosed because of their extreme phenotype. However, therapeutic options are limited as the "maturation vs. nutrition/oxygenation balance" is skewed towards the need for maturation. ...