Owen Guo's research while affiliated with The Ohio State University and other places

Publications (2)

Article
Full-text available
Purpose: Chemical corneal injuries carry a high morbidity and commonly lead to visual impairment. Here, we investigate the role of Serp-1, a serine protease inhibitor, in corneal wound healing. Methods: An alkaline-induced corneal injury was induced in 14 mice. Following injury, five mice received daily topical saline application while nine mice re...
Article
Introduction The current study was designed to test the potential role of recombinant human MG53 (rhMG53) protein on protecting against alkaline-induced corneal injury in mice. Materials and Methods A round filter paper with 2-mm diameter was soaked in 1 mol/L of NaOH solution. The mouse alkaline injury was generated by placing the filter paper di...

Citations

... Serp-1 was deemed as a potential therapeutic for reducing scarring in deep wounds [31]. Topical Serp-1 treatment also proved effective at improving wound healing after alkali-induced corneal injury in mice [29,45] 2.1A)-1-7. Cancer Therapeutics Angiogenesis is a critical factor in the development of a broad range of chronic diseases such as malignant tumors, as well as a natural defense against vascular occlusions in arthritis, wound healing, and cardiovascular disease. ...