Ott Le's research while affiliated with University of Texas MD Anderson Cancer Center and other places

Publications (31)

Chapter
The peritoneal cavity is a remarkable organ, consisting of a membrane that covers the lining of the abdominal and pelvic cavity. It reflects over the viscera to form ligaments, mesenterie, and omenta, which in turn provide the supporting network for the organs, blood vessels, lymphatics, and nerves. The peritoneum and its supporting structures prov...
Article
Purpose To study the association between CT-derived textural features of pancreatic cancer and patient outcome. Materials and Methods This retrospective study evaluated 54 patients (median age, 62 years [range, 40-88 years]; 32 men) with pancreatic cancer who underwent chemoradiation followed by surgical resection and lymph node dissection from May...
Article
Full-text available
PurposeEvaluate utility of dual energy CT iodine material density images to identify preoperatively nodal positivity in pancreatic cancer patients who underwent neoadjuvant therapy.Methods This IRB approved retrospective study evaluated 62 patients between 2012 and 2016 with proven pancreatic ductal adenocarcinoma, who underwent neoadjuvant therapy...
Article
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The pattern of disease causing acute abdominal pain has changed over last few decades, some of this has been attributed to intraabdominal cancers. The most common acute abdominal complaints in cancer patients are related to the gastrointestinal system. Abdominal emergencies in cancer patients can result from the underlying malignancy itself, cancer...
Article
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PurposeTo evaluate the quantitative attenuation and reliability of virtual non-contrast (VNC) images of the abdomen acquired from multiphasic scans with a dual-energy computed tomography (DECT) system and compare it with that of true non-enhanced images (TNC) on second- (Flash) and third- (Force) generation DECT scanners.Methods This retrospective...
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Pancreatic cysts are commonly seen with increasing use of cross-sectional imaging. They range from a benign inflammatory process that can produce pseudocysts to malignant lesions such as mucinous cystadenocarcinoma. Other common pancreatic cysts include intraductal pancreatic mucinous neoplasms and serous cystadenomas. Optimized imaging protocol de...
Article
Radiologists routinely evaluate for tumor thrombus in the portal and hepatic veins in patients with hepatocellular carcinoma (HCC) and in the renal vein and inferior vena cava in patients with renal cell carcinoma (RCC). However, tumor thrombus occurs in association with numerous other tumor types, e.g. colorectal carcinoma and pancreatic neuroendo...
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PurposeTo study the practice patterns for performance and interpretation of CT/MRI imaging studies in patients with pancreatic ductal adenocarcinoma (PDAC) at multiple institutions using a survey-based assessment. Methods In this study, abdominal radiologists/body imagers on the Society of Abdominal Radiology disease-focused panel for PDAC and from...
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Pancreatic cancer is a challenging malignancy to treat, largely due to aggressive regional involvement, early systemic dissemination, high recurrence rate, and subsequent low patient survival. Generally, 15–20% of newly diagnosed pancreatic cancers are candidates for possible curative resection. Eighty percent of these patients, however, will exper...
Article
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Pancreatic ductal adenocarcinoma is the most common primary malignancy of the pancreas. The classic imaging features are a hypovascular mass with proximal ductal dilatation. Different pancreatic pathologies can mimic the imaging appearance of carcinoma including other tumors involving the pancreas (pancreatic neuroendocrine tumors, lymphoma, metast...
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Background: The assessment of pancreatic ductal adenocarcinoma (PDAC) response to therapy remains challenging. The objective of this study was to investigate whether changes in the tumor/parenchyma interface are associated with response. Methods: Computed tomography (CT) scans before and after therapy were reviewed in 4 cohorts: cohort 1 (99 pat...
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Purpose: To compare studies with and without oral contrast on performance of multidetector computed tomography (CT) and the order to CT examination turnaround time in cancer patients presenting to the emergency department (ED). To the best of our knowledge, oral contrast utility has not previously been specifically assessed in cancer patients pres...
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Objective: To qualitatively and quantitatively compare abdominal CT images reconstructed with a new version of model-based iterative reconstruction (Veo 3.0; GE Healthcare) utilizing varied presets of resolution preference, noise reduction, and slice optimization. Methods: This retrospective study was approved by our IRB and was HIPAA compliant....
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Dual-energy CT imaging has many potential uses in abdominal imaging. It also has unique requirements for protocol creation depending on the dual-energy scanning technique that is being utilized. It also generates several new types of images which can increase the complexity of image creation and image interpretation. The purpose of this article is...
Article
284Background: There is currently no reliable biomarker for assessing the response to therapy of pancreatic ductal adenocarcinoma (PDAC). Here, we investigated how changes in the tumor/parenchyma interface associate with response. Methods: We reviewed pre- and post-therapy scans of patients who received chemotherapy and/or chemoradiation for both l...
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Full-text available
The aim of this study was to compare contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) between pancreatic-phase dual-energy computed tomography (DECT) and 120-kVp CT for pancreatic ductal adenocarcinoma (PDA). Seventy-eight patients underwent multiphasic pancreatic imaging protocols for PDA (40, DECT; 38, 120-kVp CT [control]). Using pa...
Article
The progressive advancement in computed tomography (CT) technology has enabled improved diagnosis and management of pancreatic tumors. Some of these improvements are seen in multidetector CT, dual-energy CT, perfusion CT, and post-processing techniques. Despite the technological improvement, prognosis for tumors such as pancreatic adenocarcinomas r...
Article
This review article aims to bring the reader up to date on advances in liver CT imaging, with an emphasis on the literature from the past year. Recent studies and developments in hepatic imaging using dual-energy CT, perfusion CT, low-tube-voltage imaging, and iterative reconstruction techniques are discussed.
Article
The peritoneum is a remarkably simple yet complex organ. Its choreographed folds and reflections resulting in ligaments, mesenteries, omenta, and cavities house and sustain the many vital organs and structures of the abdomen and pelvis. However, abnormal pathologic processes can also usurp the building blocks of the peritoneum. For example, the per...
Article
Peritoneal disease can be caused by a wide spectrum of pathologies. While peritoneal disease is usually caused by primary or secondary malignancies, benign diseases can occur and mimic malignancies. This article begins with an overview of peritoneal embryology and anatomy followed by a detailed description of the multimodality imaging appearance of...
Conference Paper
PURPOSE To compare contrast to noise ratio (CNR) for pancreatic ductal adenocarcinoma (PDA), performed with pancreatic phase dual energy (DECT) versus 120 kVp CT. METHOD AND MATERIALS Seventy-eight patients underwent baseline multiphasic pancreatic protocol for PDA (40 DECT, 38 120kVp). On pancreatic phase DECT, CNR for PDA at monochromatic energi...
Article
The spread of tumor in the peritoneum can be understood, although it is a complex organ. A study of its embryology, anatomy and function is of clear benefit. It is formed from a network of folds, reflections, and potential spaces produced by the visceral and parietal peritoneum. These folds and reflections begin as a dorsal and ventral mesentery, s...
Conference Paper
PURPOSE/AIM To review indications for DECT, development of imaging protocols for DECT, and tools for interpretation in the workup of pancreatic and liver tumors. CONTENT ORGANIZATION A. Introduction B. Indications for Dual Energy CT for Liver and Pancreas C. Designing Dual Energy Imaging Protocols D. Using Monochromatic Images Effectively E. How t...
Article
Many different masses can involve the kidney other than the commonly encountered renal cell carcinoma (RCC). The purpose of this article is to review the characteristic clinical and imaging findings of common and uncommon masses that predominantly present unilaterally in the adult patient, other than RCC. Awareness of such lesions and knowing the c...
Article
Masses can involve the kidney unilaterally or bilaterally. The purpose of this article is to review common and uncommon adult renal masses that present bilaterally. Clinical and imaging findings are described. Renal masses that present in a bilateral fashion can have particular clinical and imaging characteristics and knowledge of their presentatio...

Citations

... v 5.1, Siemens Healthineers). Previous publications had proven that VNC images are equally suited for quantitative assessment of absorption values as images acquired without intravenous contrast application [6][7][8]. An iterative algorithm (ADMIRE), a soft tissue kernel (Qr40), and a reconstruction interval of 1 mm were applied for CT reconstruction. ...
... Bleeding may present with overt symptoms such as hematemesis and melena, or may be occult, presenting with hemoglobin drop. The role of imaging, like other causes of upper gastrointestinal bleeding, is to detect the source of bleeding and evaluate for the presence of active bleeding [9]. Multi-phasic computed tomography (CT) angiography is usually performed in patients with significant bleeding and prior to embolization or surgical planning. ...
... Several mechanisms of metastatic spread associated with tumor thrombus through the venous system have been proposed. Direct contiguous extension of the tumor thrombus into draining veins can result in seeding the primary tumor, resulting in hematogenous dissemination of the tumor along with the venous drainage system [15]. Given the complex venous drainage system, the lungs are a common site of metastasis for breast tumors, melanomas, sarcomas, and lower rectal tumors [15]. ...
... Planned correlative studies will evaluate biomarkers of response to treatment with NBTXR3 and radiation, including characterization of circulating tumor DNA and exosomes; quantification of immune activation (T-and B-cells, peripheral blood mononuclear cells, cytokines, T-cell receptor sequencing and repertoire); analysis of the tumor microenvironment using multiplex immunohistochemistry and hypoxia staining; and radiomics measurements of PDAC tumor morphology, including delta PDAC which measures the change in sharpness of the tumor/parenchymal interface after treatment and is associated with progression-free survival and overall survival. 11,12 Radiation enhancement using NBTXR3 relies on a physical mechanism of activation by ionizing radiation and therefore may have broad applicability across tumor types. The feasibility of local endoscopic delivery of NBTXR3 may provide a general framework for delivering other local therapeutics including injectable toll-like receptor agonists, STING agonists, and radioactive agents such as 32P-OncoSil to deeper visceral tumors. ...
... On the other hand, it is important to point out the reasons why structured reports may be difficult to implement in some clinical practices. A multi-institutional survey on imaging practice patterns in pancreatic ductal adenocarcinoma [34] found that, despite being aware of the existence of specific templates of structured reports for pancreatic cancer and recognizing their benefits (preference by referring providers, improved uniformity, higher accuracy), a significant percentage of radiologists (near 40% of participants) declared that they do not use them [34]. Common concerns included interference with efficiency of workflow and complexity of the existing templates [34]. ...
... The CT scan is the best common screening test for pancreatic cancer recurrence after surgery [11]. However, CTpostoperative imaging evaluation of pancreatic cancer poses a significant challenge due to the extensive postoperative changes after surgical treatment, including postoperative fibrosis and lymph node enlargement, which may be mistaken for tumor recurrence [12,13]. ...
... Pancreatic cancer is one of the most lethal malignancies and is associated with a high mortality rate (1)(2)(3). Pancreatic ductal adenocarcinoma (PDAC) is derived from the pancreatic ductal epithelium and accounts for about 90% of pancreatic cancer (4,5). The lethality of pancreatic cancer is largely due to its difficulty to diagnose early and a lack of effective treatments. ...
... However, because of low-frequency noise especially at low doses, MBIR images show considerable degradation [10][11][12][13]. Additionally, MBIR usually requires higher computational power and longer computational time, and there are concerns regarding alterations in image texture [12,[14][15][16][17][18][19]. Hybrid IR is faster than MBIR, but the overall imaging performance is inferior in terms of noise, spatial resolution, and artifact reduction [8,[20][21][22][23]. ...
... Due to the broad and potentially insidious etiology of acute abdominal pain, early and accurate diagnosis is essential to avoid misclassification and treatment error [2]. Consequently, computed tomography (CT) is frequently performed, historically with administration of both positive oral contrast media (POCM) and intravenous (IV) contrast media [3][4][5]. ...
... The bilateral distribution of the round renal masses was consistent with metastatic disease, as described in humans. 16 The presumed metastatic renal disease was only detected on necropsy, although International Renal Interest Society stage 3 chronic kidney disease was suspected ante-mortem, accounting for the laboratory findings. ...