Oscar González-Flores’s research while affiliated with Autonomous University of Tlaxcala and other places

... In this review article, the roles of estrogen were focused on to understand the pathogenesis of SS based on the previous data including our reports. 11,12) . The effects of estrogen or 17β-estradiol (E2)are mediated by estrogen receptor α(ERα)and ...

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Molecular Pathogenesis via Sex Hormone in Sjögren's Syndrome

... In the case of other approaches to the test, it is recommended that Pup's nest seeking or olfactory discrimination test should be performed early in development to dismiss doubts of olfactory impairment that might arise in the future. Recommendations for a scoring method are plausible, considering that a social behavioral deficit is a shared attribute among NDDs including ASD [5,28,29], ADHD [28,31], OCD [35], and SZ [79][80][81]. ...

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Methods for Assessing Neurodevelopmental Disorders in Rodents: A Critical Review of Behavioral Tests and Methodological Considerations Searching to Improve Reliability

... However, male sexual health has been neglected in clinical research, with few registered studies addressing this issue. Several studies have reported that VPA may interact with reproductive factors, leading to male sexual dysfunction [2,11,12]. Both preclinical and clinical studies have shown that prolonged use of VPA in epilepsy is associated with reduced sperm count and motility, as well as increase in abnormal sperm [11,[13][14][15]. ...

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Understanding the impact of valproate on male fertility: insights from preclinical and clinical meta-analysis

... Eleven 12-week-old female mice from each strain (C57BL/6J and C58/J) were cycled. Vaginal smears were taken every 24 h for twenty consecutive days, starting at 10:00 a.m., following the methodology used by Goldman and colleagues (Goldman et al., 2007). A 1000 μL blunt-tipped micropipette was used, with 40 μL of sterile 0.9 % saline solution. ...

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Disruptions in reproductive health, sex hormonal profiles, and hypothalamic hormone receptors content in females of the C58/J mouse model of autism

... En ratas OVX tratas con BE, la administración de apelina-13 facilita la CL de manera dualística ya que una dosis intermedia de 0.75 µg fue la que indujo la mayor respuesta conductual (similar a la ejercida por la P), mientras que la dosis de 1.5 µg indujo CL marginal. 37 Además, la CL inducida por apelina-13 está relacionada con la vía de óxido nítrico, ya que la administración de varios inhibidores de esta vía bloquearon la CL inducida por este péptido. 38 ...

Reference:

Hormonas y neurociencias

... This lordosis score was adapted from the proposed quantification by Hardy and DeBold [54]. Then, we also calculated the female´s lordosis quotient (LQ) using the formula [LQ = (number of "full" lordosis / 10 mounts) × 100], as performed in [55]. ...

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Sex-Related Gene Expression in the Posterodorsal Medial Amygdala of Cycling Female Rats Along with Prolactin Modulation of Lordosis Behavior

... We have found previously that EE has a significant influence on the sexual behavior of male rats. Males exposed to EE are faster to initiate sexual behaviors and achieve more ejaculations compared to males in an unenriched group (Dorantes-Barrios et al., 2021). Therefore, the present study aimed to evaluate the effect of EE conditions on spatial and declarative memory and sexual behavior patterns (mounting, intromission, and ejaculation) in male Sprague-Dawley rats exposed to VPA on day 12.5 of gestation. ...

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Influence of environmental enrichment on sexual behavior and the process of learning and memory in a rat model of autism with valproic acid

... However, some researchers are interested in animals that show short or long latencies, and even in those that fail to ejaculate despite copulatory training. In a rat population, there will be male rats with short, intermediate, and long ejaculation latencies and correspond to endogenous ejaculatory phenotypes [32][33][34][35]. It should be mentioned that rapid males show short ejaculation latencies from the first, second, or third tests onwards. ...

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Copulation in Rats: Analysis of Behavioral and Seminal Parameters

... This suggests strongly that an indirect mechanism must be involved in the release of GnRH from hypothalamic neurons. Accordingly, we found that intracerebral administration of antide blocked lordosis behavior induced by reduced A-ring progestins, GnRH, PGE2, leptin, G1 (a GPER-1 agonist), and by VCS (García-Juárez et al., 2020;García-Juárez et al., 2011;Domínguez-Ordóñez et al., 2018;Gómora-Arrati et al., 2008). The results of the present work coincide with those as antide also blocked OTinduced lordosis through a series of processes that result in the release of GnRH from GnRHergic neurons activating their GnRH-1 receptors in the hypothalamus trigger the expression of lordosis behavior (see Fig. 5). ...

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Oxytocin induces lordosis behavior in female rats through the prostaglandin E2/GnRH signaling system

... Basado en esos hallazgos, nuestro laboratorio propuso que el complejo Src/RP/MAPK es crucial en la regulación de la CL. Así, la administración intraventricular de PP2, un inhibidor específico de la cinasa Src, redujo la CL inducida por esteroides (E2, P, 5α-DHP, 5α,3α-Pgl, 5β-DHP y 5β,3β-Pgl), péptidos (leptina, GnRH), PGE2 y por la estimulación vaginocervical en ratas pretratadas con BE. [27][28][29][30] Por lo tanto, esos agentes al actuar a través de mecanismos directos e indirectos, estimulan los receptores de membrana acoplados a proteínas G (GPCR, del inglés G protein coupled receptor) ubicados en la membrana activando a la Src. La señalización de Src a través del sistema MAPK ocurre en un contexto de complejo multiproteínico con ambos RE y RP actuando como engranajes para activar una variedad de efectores enzimáticos. ...

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Hormonas y neurociencias