Or Yudco's research while affiliated with Hebrew University of Jerusalem and other places

Publications (2)

Article
The brain undergoes rapid, dramatic, and reversible transitioning between states of wakefulness and unconsciousness during natural sleep and in pathological conditions such as hypoxia, hypotension, and concussion. Transitioning can also be induced pharmacologically using general anesthetic agents. The effect is selective. Mobility, sensory percepti...
Article
In light of the general shift from rats to mice as the leading rodent model in neuroscience research we used c-Fos expression as a tool to survey brain regions in the mouse in which neural activity differs between the states of wakefulness and pentobarbital-induced general anesthesia. The aim was to complement prior surveys carried out in rats. In...

Citations

... Specifically, there is a ubiquitous presence of neurons whose activity increases during anesthesia throughout the brain. 55 The balance in recruitment of anesthesia-on versus wake-on neuronal populations throughout the brain may be a key driver of regional and global vigilance states. We anticipate that MEA-enabled electrophysiological analysis strategy can be potentially replicated on small aquatic model organisms such as embryonal and larval stages of fish and amphibians as well as diverse invertebrate species. ...
... Several studies have confirmed that anesthetics impacted neural activities, including significant downregulation of Cxcl12 mRNA expression in primary hippocampal neurons [19], suppressing neural activities in cerebral cortex [20], inhibiting excitatory transmitter release by blocking presynaptic Ca 2+ channels or extracellular mechanisms [21], and leading to distinct spatiotemporal activity in principal neurons of the mouse olfactory cortex [22]. Not only that, a preliminary study also showed that the modulation of functional connectivity by low-frequency rTMS varied considerably among the isoflurane, propofol and dexmedetomidine groups [23]. ...