Ondřej Rychecký's research while affiliated with Uni Chem and other places
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Publications (6)
The present study investigates the physicochemical properties and stability of a novel lipid-based formulation—surfactant-enriched oil marbles containing abiraterone acetate. While the biopharmaceutical performance of this formulation has been reported recently, this study aims to fill the gap between a promising in vivo performance and industrial...
Encapsulation of active compounds into liquid marbles (LMs) represents an emerging technology with potential applications in several fields including food, cosmetics and pharmaceutics. However, existing methods for the preparation of LMs are either based on manual one-by-one fabrication or on batch processes such as high-shear granulation, which la...
Abiraterone acetate has limited bioavailability in the fasted state and exhibits a strong positive food effect. We present a novel formulation concept based on the so-called oil marbles (OMs) and show by in vitro and in vivo experiments that the food effect can be suppressed. OMs are spherical particles with a core-shell structure, formed by coatin...
Many new therapeutic candidates and active pharmaceutical ingredients (APIs) are poorly soluble in an aqueous environment, resulting in their reduced bioavailability. A promising way of enhancing the release of an API and, thus, its bioavailability seems to be the use of liquid oil marbles (LOMs). An LOM system behaves as a solid form but consists...
A liquid marble is a liquid droplet encapsulated in a hydrophobic powder that adheres to the liquid surface. Liquid marbles preparation is very simple – a small amount of liquid is carefully dripped on the layer of hydrophobic powder consisting of nano-or micro particles, which spread spontaneously at the interface liquid/air. This process results...
The ability to simulate the 3D structure of a human body is essential to increase the efficiency of drug development. In vivo conditions are significantly different in comparison to in vitro conditions. A standardly used cell monolayer on tissue culture plastic (2D cell culture) is not sufficient to simulate the transfer phenomena occurring in livi...
Citations
... 5 Abiraterone acetate is a Biopharmaceutics Classification System class IV compound, with an extremely low oral bioavailability when administered in the fasted state. 6 However, the administration of abiraterone acetate with highfat food results in up to a 10-fold increased area under the concentration-time curve (AUC) and up to a 17-fold increase in the maximum plasma concentration (C max ) of abiraterone. 7 Because of the low oral bioavailability and significant food effect of abiraterone acetate, its administration carries a risk of toxicity and inaccurate dosing. ...
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... [3], immense progress has been made in terms of applications. LM has successfully demonstrated a potential for many applications such as acceleration sensors [6,7], thermal sensors [8], water pollution revelation [9], pressure-sensitive adhesives [10], gas sensing [11], micro-reactors [12,13], material synthesis [14], cell culture [15], drug delivery and sensitivity test [16,17], compound lenses [18] and many more. ...
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... [3], immense progress has been made in terms of applications. LM has successfully demonstrated a potential for many applications such as acceleration sensors [6,7], thermal sensors [8], water pollution revelation [9], pressure-sensitive adhesives [10], gas sensing [11], micro-reactors [12,13], material synthesis [14], cell culture [15], drug delivery and sensitivity test [16,17], compound lenses [18] and many more. ...
