Olga Novick's scientific contributions

Publication (1)

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Human personality traits which can be reliably measured by any of a number of rating scales, show a considerable heritable component. The tridimensional personality questionnaire (TPQ) is one such instrument and was designed by Cloninger to measure four distinct domains of temperament - Novelty Seeking, Harm Avoidance, Reward Dependence and Persist...


... Thus, carrying the D4.7 variant has been linked to attention deficit hyperactivity disorder (ADHD), major depressive disorder, gambling, drug dependence, smoking, alcoholism, and Parkinson's disease Kaplan et al. 2008;Faraone et al. 1999;Manki et al. 1996;Ricketts et al. 1998;Laucht et al. 2005). Several studies suggested that the longer allele variants, with 7 and more repeats, are connected to specific behavioural phenotypes, including novelty seeking and risky behaviour, impulsivity, limited emotional feedback, but effective problem solving (Hohmann et al. 2009;Dmitrieva et al. 2011;Ebstein et al. 1996). Remarkably, schizophrenic patients with the shorter alleles (D4.2 and D4.4) manifest a higher therapeutic response to typical antipsychotic drugs (APDs) compared to those with D4.7 (Cohen et al. 1999). ...