Olga Novick’s research while affiliated with Sarah Herzog Hospital and other places

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Publications (1)


Dopamine D4 receptor (D4DR) exon III polymorphism associated with human personality trait of Novelty Seeking
  • Article
  • Full-text available

February 1996

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1,628 Reads

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1,481 Citations

Nature Genetics

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Olga Novick

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Roberto Umansky

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Human personality traits which can be reliably measured by any of a number of rating scales, show a considerable heritable component. The tridimensional personality questionnaire (TPQ) is one such instrument and was designed by Cloninger to measure four distinct domains of temperament - Novelty Seeking, Harm Avoidance, Reward Dependence and Persistence-that are hypothesized to be based on distinct neurochemical and genetic substrates. Cloninger proposed that individual variations in the Novelty Seeking trait are mediated by genetic variability in dopamine transmission. Individuals who score higher than average on the TPQ Novelty Seeking scale are characterized as impulsive, exploratory, fickle, excitable, quick-tempered and extravagant, whereas those who score lower than average tend to be reflective, rigid, loyal, stoic, slow-tempered and frugal. We now show that higher than average Novelty Seeking test scores in a group of 124 unrelated Israeli subjects are significantly associated with a particular exonic polymorphism, the 7 repeat allele in the locus for the D4 dopamine receptor gene (D4DR). The association of high Novelty Seeking and the 7-repeat allele was independent of ethnicity, sex or age of the subjects. This work, together with the accompanying confirmations in this issue, provides the first replicated association between a specific genetic locus involved in neurotransmission and a normal personality trait.

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Citations (1)


... Previous studies have established an association between impulsivity and genetic variations in enzymes related to dopamine transporter activity, dopamine receptors and do- ); ** By PCL-5 ; ↑ indicates a positive association between the variable and TQ-Tg-IgG (higher in the T. gondii IgG top quartile cases); ↓ indicates a negative association between the variable and TQ-Tg-IgG (lower in the T. gondii top quartile cases); OR > 1 indicates a positive association (variable is higher in T. gondii top quartile of serointensity cases); OR < 1 indicates a negative association (variable is lower in T. gondii top quartile of serointensity cases); * indicates statistical trend (0.05 < p ≤ 0.1); ** indicates statistical significance (0.01 ≤ p ≤ 0.05); *** indicates statistical significance (0.001 < p < 0.01); **** indicates statistical significance (p ≤ 0.001); BDI -Beck Depression Inventory; BSS -Beck Scale for Suicidal Ideation; PCL-5 -Posttraumatic Stress Disorder Checklist-5; PTSD -Posttraumatic Stress Disorder. pamine metabolic pathways (Ebstein et al. 1996, Retz et al. 2003, Bortolato and Shih 2011, Malloy-Diniz et al. 2013, Chester et al. 2016. ...

Reference:

Toxoplasma gondii, suicidal behaviour and suicide risk factors in US Veterans enrolled in mental health treatment
Dopamine D4 receptor (D4DR) exon III polymorphism associated with human personality trait of Novelty Seeking

Nature Genetics