Oladapo Odumeru's research while affiliated with University College Dublin and other places

... The prognosis for patients with glioma is still limited to 15 months, although patients are treated with chemotherapyradiotherapy (Linz, 2010). Increasing evidence indicated that anesthetics and anesthetic techniques directly affect cancer cell tumorigenesis and progression, and have an important impact on the outcome of surgery treatment for tumor patients (O'Leary et al., 2000). Recent experimental data highlighted that many of the most commonly used anesthetics in surgical oncology, whether general or local agents, can alter gene expression and cause epigenetic changes via modulating miRNAs and circRNAs (Gao et al., 2021;Liu et al., 2021;Tabnak et al., 2021;Wang et al., 2020). ...

... Such future in-depth knowledge could help to develop novel prophylactic strategies and therapeutic approaches that, by maintaining and/or restoring the correct sialylation status, could contribute to prevent and/or treat cell senescence. In this regard, although experimental data are still scanty (Odumeru et al., 1997;Sprenger and Duncan, 2012), various possible treatments have been investigated to restore the normal sialylation status of nervous tissue in neurological injuries and aged-related neurodegenerative pathologies (Saini et al., 2020;Rawal and Zhao, 2021;Sato and Kitajima, 2021), as well as the sialylation status of skeletal muscle tissue in muscle pathologies such as HIBM which presents similarities with sarcopenia (Carrillo et al., 2018;Pogoryelova et al., 2018). Therefore, hopefully the development of additional innovative treatments in association with novel prophylactic strategies could help in restoring/preserving the normal sialylation in nervous and skeletal muscle tissues, favoring aging slowing and thus contributing to achieve a successful aging with prevention of age-related pathologies. ...

... Anesthetic/techniques may affect cancer cell biology such as proliferation, m invasion and apoptosis, and thus influence the clinical outcomes of cancer following surgery. Inhalational anesthetics have been reported to be capable of re gene expressions in human breast cancer and neuroblastoma [18], suggested to ex proliferative effects in glioma cells [19] and decreased cell viability of non-small c cancer cells [20]. Sevoflurane also has been reported to regulate multiple miR normal cells including brain [21] and peripheral organs [12,22] and in cancer cells to cell biological changes. ...

... Expression of PSA is associated with cellular migration, axon induction and also contacts with their target [64]. PSA expression in most cancer cells is correlated with tumor metastasis and associated with tumor differentiation as well as serves as an onco-developmental antigen [65,66]. In the present study, ASH-WEX significantly reduced the surface expression of PSA-NCAM and these findings are also supported by Western blotting results. ...

... Overall, it is generally recognized that CBZ and VPA display different mechanisms of action. VPA has been proposed to attenuate cAMP accumulation [67,70], possibly by increasing PDE-activity [70]. CBZ, however, has been suggested to act at the level of cAMP production by having an inhibitory effect on ACs [66], potentially through binding to a hydrophobic catechol-estrogen binding site on the AC enzyme [68]; alternatively, CBZ may interact with adenosine A1 (G i ) and A2 (G s ) receptors [63,71]. ...