Oguejiofor Benigna's scientific contributions
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Publications (6)
To contain the emergence and spread of drug resistant bacteria including those that produce metallo-β-lactamases, it is important to curtail the use of antibiotics in non-hospital environment such as abattoir and poultry farms. Metallo-β-lactamase (MBL) are enzymes expressed by bacteria, and which mediate bacterial resistance to the carbapenems. Th...
The increasing prevalence of antibiotic resistant bacteria in the community is a public health issue because this phenomenon compromises our ability to effectively treat infectious diseases since these organisms such as those that express metallo-β-lactamase (MBL) are usually resistant to a wide variety of antibiotics. This study investigated the f...
Effective monitoring of the development and spread of antimicrobial resistant bacteria including AmpC producing Escherichia coli in abattoir is critical to the containment of disease outbreak due to these microbes. The colonization of slaughtered farm animals with E. coli producing AmpC enzymes and other antibiotic resistant genes portend serious p...
Antimicrobial resistance in food chain is fast becoming a global phenomenon that is likely to pose grave health challenges to humans–owing to the emergence and spread of drug resistant bacteria in food-producing animals. This study investigated the occurrence of AmpC enzyme in Klebsiella spp. isolated from anal swabs of cow in a local abattoir in A...
Citations
... Since the first report in the 1990s for MBL-producing bacteria, MBLproducing bacteria have been identified around the world (Tarhani et al., 2016). The existence of MBL-producing bacteria in the hospital and nonhospital environment makes the use of the carbapenems under threat (Chika et al., 2018). In India, a study that was conducted by Amudhan and colleagues, 2012 they observed that the prevalence of MBL genes (bla VIM and bla IMP ) were detected in 92 (51.4%) isolates. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281187688799-1694381477236_Q64/Chika-Ejikeugwu.jpg)
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... Previous treatment with different types of antibacterial agents, including 3GCs and carbapenems, and visitation to hospitals, are factors that facilitate colonization of individuals by ABR salmonellae (Lugito and Cucunawangsi, 2017;Whistler et al., 2018;Adikwu et al., 2018). Animals are also important reservoirs of 3GC-and carbapenemresistant organisms (Crump and Heyderman, 2015;Whistler et al., 2018), and reports showed that these organisms are haboured by livestock in Nigeria (Jajere et al., 2015;Ejikeugwu et al., 2017;Ojo et al., 2018;. Ankpa is a heavily-populated cosmopolitan agrarian town located in Kogi State North-central, Nigeria. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/534875028377600-1504535552953_Q64/Chika-Ezeador.jpg)
... This is because antibiotics are used in the rearing of livestock and poultry birds, and the antibiotic residues in these animals may cause the emergence of resistant bacteria via selective pressure. The irrational and off-label use of antibiotics in animal husbandry and in other agricultural practices allows bacteria to develop and acquire drug resistant genes over time through selective pressure, and this phenomenon impacts negatively on the efficacy of some available antibiotics [4]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/278727297650715-1443465174914_Q64/Malachy-Ugwu.jpg)
... Each disk was aseptically placed on Mueller-Hinton agar plates containing the test isolates (adjusted to 0.5 McFarland turbidity standards); and the plates were incubated at 30 o C for 18-24 hours. Susceptibility testing was carried out in triplicate for each isolate and the mean inhibition zone diameter (IZD) was recorded as the final IZD and reported as per the CLSI guidelines [11,12]. P. aeruginosa ATCC 25668 was used as quality control strain for the antimicrobial susceptibility studies. ...
... The long-term and undue use of antibiotics in livestock, poultry and other agricultural activities selects for drug resistance in pathogenic bacteria including E. coli. [6,7,8] The increasing global problem of antibiotic resistance in livestock environments has been previously reported. [9,10] Escherichia coli is the most prevalent facultative anaerobic Gram negative bacterial species that inhabit the gastrointestinal tract (GIT) of humans and animals. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/763899800477697-1559139313228_Q64/Michael-Adikwu.jpg)
... Oligonucleotide primers used for PCR experimentAntimicrobial Susceptibility Testing Susceptibility studies were performed on all ESBL-and AmpC-producing bacterial isolates screened and isolated in this study. This was done using our previous method and in tandem with the modified Kirby-Bauer disk diffusion technique on Mueller Hinton agar (Oxoid, UK) plates according to the criteria of the Clinical Laboratory Standards Institute (CLSI) and according to a previous methodology[2,17,18]. Oxoid, UK] were used for susceptibility studies. ...
