Oded Nahlieli’s research while affiliated with Ben-Gurion University of the Negev and other places

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Publications (137)


Thirty years of experience and current trends in the management of sialolithiasis: A narrative review
  • Literature Review

March 2025

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4 Reads

British Journal of Oral and Maxillofacial Surgery

Oded Nahlieli

Diffuse cytoplasmic VDAC1 staining of the human myocardium served as the positive control (VDAC1 magnification ×100).
(A): A clear transition zone between normal-appearing mucosa with high VDAC1 expression and dysplastic/neoplastic mucosa with decreased VDAC1 expression (asterisk) (magnification ×100). The dysplastic grade is evaluated as “high grade”. (B): OSCC of the tongue showing decreased to absent VDAC1 staining of tumor islands invading the positively stained myocytes, a positive internal control (VDAC1 ×100, inset VDAC1 magnification ×200). (C): OSCC of the oral mucosa presenting decreased VDAC1 staining, while some inflammatory cells express VDAC1 (VDAC1; magnification ×400).
(A): Fibrous hyperplasia of the oral mucosa: Dense fibrous connective tissue lined by hyperkeratotic oral epithelium (H&E magnification ×100). (B): fibrous hyperplasia of the oral mucosa, Diffuse cytoplasmic VDAC1 staining in the epithelium. (VDAC1 magnification ×100).
VDAC1 live or die flow chart: a schematic representation of VDAC1 involvement in cell survival (A) or death (B). (A) VDAC1 attaches HK, inducing cell energy production and protection from mitochondria-mediated apoptosis by blocking the interactions with pro-apoptotic BAX proteins. (B) Elevated Ca²⁺ levels and detachment of HK from VDAC1 promotes the oligomerization of VDAC1 to create large pores capable of passing apoptogenic proteins AIF and Cyto c. In addition, VDAC1 forms an oligomer complex with BAX proteins to create a pathway for Cyto c. Abbreviations: VDAC 1—voltage-dependent anion channel 1; HK—hexokinase; Cyto C—cytochrome c; AIF—apoptosis-inducing factor; Ca—calcium.
Demographic details of the study groups.

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Voltage-Dependent Anion Channel 1 Expression in Oral Malignant and Premalignant Lesions
  • Article
  • Full-text available

March 2023

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44 Reads

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2 Citations

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Jacob Pettesh

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Eli Michaeli

Background: The voltage-dependent anion channel 1 protein (VDAC1) plays a role in cellular metabolism and survival. It was found to be down or upregulated (overexpressed) in different malignancies but it was never studied in application to oral lesions. The purpose of this study was to retrospectively evaluate the expression of VDAC1 in biopsies of oral premalignant, malignant, and malignancy-neutral lesions and to examine the possible correlations to their clinicopathological parameters. Materials and methods: 103 biopsies including 49 oral squamous cell carcinoma, 33 epithelial dysplasia, and 21 fibrous hyperplasia samples were immunohistochemically stained with anti-VDAC1 antibodies for semi-quantitative evaluation. The antibody detection was performed with 3,3′-diaminobenzidine (DAB). The clinicopathological information was examined for possible correlations with VDAC1. Results: VDAC1 expression was lower in oral squamous cell carcinoma 0.63 ± 0.40 and in oral epithelial dysplasia 0.61 ± 0.36 biopsies compared to fibrous hyperplasia biopsies 1.45 ± 0.28 (p < 0.01 for both; Kruskal–Wallis test). Conclusion: Oral squamous cell carcinoma and epithelial dysplasia tissues demonstrated decreased VDAC1 protein expression if compared to fibrous hyperplasia samples, but were not different from each other, suggesting that the involvement of VDAC1 in oral carcinogenesis is an early stage event, regulating cells to live or die.

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Intra-oral Acantholytic Squamous Cell Carcinoma: 55 Cases. Is this Variant more Aggressive?

June 2022

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31 Reads

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8 Citations

Head and Neck Pathology

We aimed to collect and analyze available cases of intraoral acantholytic squamous cell carcinoma (aSCC), that consisted of the authors’ cases and cases derived from the existing literature, with an emphasis on the pathological staging and patient outcome. Our research question was whether aSCC is more aggressive than conventional SCC. The literature was searched for documented cases of aSCC involving the intra-oral mucosa, excluding those from the lips and tonsils, and seven new cases were added from our files. The authors compared the obtained aSCC data to existing data for conventional SCC. Fisher Exact or Pearson’s χ2 tests were used for categorical variables. Fifty-five cases of intraoral aSCC were reviewed, of which 48 were retrieved from the literature. Analysis of the published cases was reinforced by contacting the authors of all the papers with incomplete data for further clarifications. The most common sites of aSCC were the tongue (24/55) and the maxilla/maxillary gingiva and/or palate (11/55). The overall survival rate was 36/53 (67.9%) with a mean follow-up period of 22 months against 62.5% for conventional SCC (p = 0.6). No statistically significant difference between the two variants of the tumor with respect to the oral cavity was detected. The differences in age, sex, survival rate, staging, and locations were not statistically significant. Based on the available data from 55 cases, there is no evidence to suggest that aSCC is more aggressive than conventional SCC in intraoral cases.


Sialoendoscopy

February 2022

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13 Reads

This chapter describes the common complications associated with interventional sialoendoscopy and endoscopically assisted intraoral extraductal surgeries and presents suggestions of how to avoid and manage these complications. The complications associated with sialoendoscopy stem from different origins than those seen in radical salivary gland surgery. The majority of radical surgery complications focus on neurological damage due to unintentional damage to facial nerves during surgery. The primary complications associated with sialoendoscopy are avulsion of the salivary duct, secondary strictures, gland swelling, salivary fistulas and perforations, traumatic ranulas, lingual nerve damage, bleeding and hematoma. Lingual nerve paresthesia is a rare complication of sialoendoscopic procedures for the submandibular gland. Bleeding is most common with sialoendoscopic procedures of the submandibular/sublingual gland. The baskets that are used for sialolith extraction are 0.3–0.8 mm thin and may dislodge if they are aggressively handled. Overall, sialoendoscopy‐related complications are significantly less prevalent in comparison to traditional surgery of the salivary glands.


Transoral Endoscopic Plating for Orbital Blowout Fractures

June 2021

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12 Reads

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1 Citation

The Journal of craniofacial surgery

Orbital fractures account for up to 40% of craniofacial injuries. In this article, the authors present the transoral endoscopy-assisted plating technique for treating orbital blowout fractures (OBF). A retrospective analysis of 56 cases treated with transoral endoscopy-assisted approach was performed. Immediate versus delayed surgery decision-making was performed by using our 2-week algorithm. The surgical technique included only transoral incisions, forced duction and "pulse" tests, osteotomy, endoscopic inspections, the reduction with a curved elevator and an indwelling balloon, the retrieval of prolapsed fatty tissue back into the orbit, removal of sharp bony fragments, adaptation of the titanium mesh to the orbital floor and its fixation with screws to stable bony structures, reattachment of the osteotomized lateral wall, and postoperative computed tomography (CT) scan with 3D CT reconstruction. The overall success rate of surgeries was 96%. The resolution of comorbidities resulted in a normal globe position, normal eye movement, and the resolution of diplopia. Postoperative complications were insignificant with one case of surgical edema and one case of infection and sequestration that appeared six months after surgery. These results remained unchanged after 20 to 24 months of follow-up. The suggested minimally invasive transoral technique can be effectively implemented in cases of OBF as well as in cases when the medial wall of the orbit is involved. Our results presented a high success rate with minimal rate of complications, thus our technique is a safe way with minimal morbidity for treating OBF.


Surgical approach to a severe case of sodium hypochlorite accident: a case report and review of the literature

June 2021

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41 Reads

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9 Citations

Quintessence international (Berlin, Germany: 1985)

Sodium hypochlorite (NaOCl) is the most common irrigant used in modern endodontics due to the antimicrobial properties against bacteria, the powerful oxidative activity, and the ability to dissolve organic soft tissues. When NaOCl extrudes the apex of the root, commonly referred as "sodium hypochlorite accident," it can lead to devastating outcomes leading to long-term functional and esthetic deficits. Currently, no clear guidelines exist as to how these patients should be managed. The purpose of this paper is to present a case report and a review of literature and to propose an adequate surgical treatment protocol for this unfortunate event.




Trans-implant treatment of chronic recurrent maxillary sinusitis via dynamic implants with an internal port: Experience with 31 cases

February 2020

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1,525 Reads

International Journal of Oral and Maxillofacial Surgery

This study was performed to test a protocol for trans-implant treatment of chronic recurrent maxillary sinusitis (CRS), via implants with an internal removable sealing screw. The appropriate indications for treatment, optimal number of treatment sessions, and general schedule of treatment and follow-up were assessed. This was a retrospective study of 31 patients with CRS who were managed with trans-implant lavage. Of these patients, 28 (referred for a sinus elevation procedure) underwent a simultaneous implantation procedure and treatment of the sinusitis. Three patients received treatment for sinusitis via an already existing implant. The suggested sinusitis treatment protocol includes the drainage of pus through the punctured sinus floor and three sessions of antral irrigation/lavage, four cone beam computed tomography scans, and four transnasal endoscopic observations. The suggested combined protocol includes the simultaneous evaluation of the implant status and the sinusitis treatment results on days 30 and 60 after surgery. Of the 31 patients, 28 (90%) had complete relief of most of their symptoms (nasal obstruction/discharge, anosmia/hyposmia) up to day 30 postoperative. Follow-up nasal endoscopy demonstrated no evidence of active sinus disease. Twenty-seven implants were well-osseointegrated and were still in use for prosthetic purposes. In one case, the implantation failed because of poor bone quality. For the remaining 30 cases, both clinical and radiological results showed stability of the implants and no CRS recurrence during the whole follow-up period. The dental implant with an internal central port and an integral sealing screw may be used for drainage, irrigation, observation, and further treatment of the maxillary sinus in cases of CRS.



Citations (73)


... Abba et al. found tongue (24/55) and the maxilla/maxillary gingiva and/or palate (11/55) as the most common sites to be involved by ASCC. Based on the data available with them, they found no evidence that would suggest that ASCC is more aggressive than conventional SCC in intraoral regions [7]. However, this tumor is reported to have a diverse biologic behavior, because of which it can metastasize to distant places, thus leading to poor prognosis. ...

Reference:

Histopathological Variants of Oral Squamous Cell Carcinoma Operated at a Cancer Institute in North India
Intra-oral Acantholytic Squamous Cell Carcinoma: 55 Cases. Is this Variant more Aggressive?

Head and Neck Pathology

... 11,22 It can lead to extensive tissue damage, life-threatening situations, and residual or long-term complications. [23][24][25][26][27] Therefore, from the perspectives of clinicians or operators, NaOCl accidents can have medico-legal implications and be associated with malpractice. 28,29 A recent clinical study by Özdemir et al. demonstrated a low rate of NaOCl extrusion and accidents during root canal irrigation with NaOCl. ...

Surgical approach to a severe case of sodium hypochlorite accident: a case report and review of the literature
  • Citing Article
  • June 2021

Quintessence international (Berlin, Germany: 1985)

... Salivary gland diseases, in which sialolithiasis is one of the major causes of sialadenitis, are increasingly common and account for approximately 50% of major salivary gland diseases. 15,16 Traditional diagnostic methods for sialolithiasis can be applied to visualize the stone directly or indirectly through ductal dilatation before the site of obstruction. 17 However, they would not be ideal for detecting small, noncalcified intraductal stones and unable to distinguish salivary stones from other types of calcifications around the submandibular glands, such as calcified lymph nodes or phleboliths. ...

Endoscopic Transoral Removal of Distal and Proximal Stones from the Parotid Duct
  • Citing Chapter
  • January 2021

... 45,49 Female predominance was seen in patients with IMTs in the urinary bladder and jaw bones. 42,48 The age of patients with different disease sites seemed to be similar. In the groups where the mean age was lower, some paediatric patients were included, which was an exclusion criterium for our study. ...

Central Inflammatory Myofibroblastic Tumor of the Jawbones: Exceptional Location of an Uncommon Entity

Archives of Clinical and Medical Case Reports

... In addition, previous reports have also described nonulcerated oral lesions affecting multiple subsites, including the palate bilaterally. 6 Mantle cell lymphoma is histologically diverse and the current World Health Organization classification of 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 lymphoid tumors recognizes several histologic variants. 4 Although the majority of cases are classified as the classic variant, characterized by small monotonous neoplastic cells, cases composed of larger or pleomorphic cells (blastoid or pleomorphic variants) may also be found. ...

Mantle cell lymphoma of the oral cavity: An uncommon site for an uncommon lesion, two new cases and literature review
  • Citing Article
  • April 2020

Oral Oncology

... The histopathological features of this variant of SCC include tubular and alveolar forms, also known as pseudoglandular structures, dyskeratotic cells, and significant acantholysis caused by the loss of cohesiveness of tumor cells. The acantholytic cells may show variable appearance with a large size and numerous mitotic figures [6]. Unlike the acantholytic SCC, classical SCC lacks a distinct wall or cohesive layer of cells encircling the acantholytic cells, although it may have distinct areas of cleft development with dyskeratosis and acantholysis (Fig. 1). ...

Oral variant of acantholytic squamous cell carcinoma—Histochemical and immunohistochemical features
  • Citing Article
  • November 2019

Acta Histochemica

... Semiquantitative histologic scoring system for diagnosing carcinoma cuniculatum Some cases have revealed that CC is negative for CK19, which is an odontogenic epithelial marker[4,12]. In contrast, OKC is usually positive for CK19. ...

Rare variants of head and neck squamous cell carcinoma –differential immunohistochemical profiles
  • Citing Article
  • September 2019

Acta Histochemica

... Fourteen different brands of implants were used; 5 articles [10,12,25,28,41] did not report any information on the dental implant brands; 4 studies [10,13,17,31] did not provide any information on the dental implant diameters. ...

Graftless sinus floor augmentation with an internal-port implant: Long-term experience
  • Citing Article
  • January 2019

Quintessence international (Berlin, Germany: 1985)

... The effects of shock waves in humans were first investigated in the 1960s, and was first used to treat kidney and gallbladder stones in the 1970s, as the shock waves carry sufficient energy to break up the calculi (45,46). Extracorporeal shock wave lithotripsy has remained a first-line treatment option for nephrolithiasis and ureterolithiasis since the 1980s (47). ...

Extracorporeal Lithotripsy
  • Citing Article
  • September 2018

Atlas of the Oral and Maxillofacial Surgery Clinics

... Finally, as seen in cases of implants in the maxillary bone, the proximity of the implant to the maxillary sinus floor led to the conclusion that the internal port of the implant (with sealing screw) could be used for the treatment of sinusitis. The preliminary results of this treatment were reported recently 16 . ...

Transimplant antral lavage as minimally invasive treatment of chronic rhinosinusitis: Preliminary report of 11 consecutive cases
  • Citing Article
  • January 2018

Quintessence international (Berlin, Germany: 1985)