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... Hoof lamellar damage is considered the most direct cause of laminitis [12], and studies have suggested that metalloproteinases (MMPs) may be involved in lamellar injury [13][14][15][16]. Based on these findings, some studies have explored the effects of drugs such as phosphodiesterase [17] and pentoxifylline [17,18] Therefore, there is a need for in vivo data on its effectiveness. ...
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