O. Ishihara's research while affiliated with Saitama Medical University and other places

Publications (25)

Article
The United Nations refers to South-South cooperation as a broad framework of collaboration between developing countries in the Global South. It can take place on a bilateral, regional, or interregional basis. Its main purpose is to share knowledge, skills, resources and successful initiatives to meet development goals through concerted partnerships...
Article
Study question What was the impact on treatment age in Japan after a subsidy policy change that set age limits for assisted reproductive technology (ART) treatment? Summary answer The national policy introducing age limits in the subsidy may have promoted ART treatment among younger women. What is known already Japan has provided partial subsidie...
Article
title International Committee for Monitoring Assisted Reproductive Technologies (ICMART) Preliminary World Report on ART, 2018 Study question In 2018 what was global utilization, effectiveness and safety of ART? Summary answer Globally, ART utilization and data collection continue to increase but with wide variations in utilization, effectiveness...
Article
Study question What is the probability that patients will receive assisted reproductive technology (ART) treatment based on their out-of-pocket payment and income class? Summary answer Higher-income patients opted for ART even at a higher cost, whereas an out-of-pocket payment was the most influential determinant in all income groups. What is kno...
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Study question: What were utilization, outcomes and practices in assisted reproductive technology (ART) globally in 2008, 2009 and 2010? Summary answer: Global utilization and effectiveness remained relatively constant despite marked variations among countries, while the rate of single and frozen embryo transfers (FETs) increased with a concomit...
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Full-text available
Introduction: This is the fourteenth report of the European IVF-monitoring (EIM), the ESHRE register on assisted reproductive techniques (ART) organization. This report deals with the results of treatments initiated during 2010. Methods: Data were collected from existing national registries in 30 countries (data sent in at the time of abstract dea...
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Full-text available
Study question To determine whether hypoxic microenvironment might be a factor in influencing cell migration of endometrial stromal cells in endometriosis
Article
Introduction This is the Thirteenth report of the European IVF-monitoring (EIM), the ESHRE register on assisted reproductive techniques (ART) organization. This report deals with the results of treatments initiated during 2009. Methods Data were collected from existing national registries in 30 countries (data sent in at the time of abstract dead...
Article
Introduction Due to improved culture techniques and composition of culture media as well as technical equipment, assisted reproductive technology has achieved higher success rates. Based on past experience, physicians believe that more than one embryo should be transferred to guarantee success, which in turn leads to twin pregnancy rates between 20...
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Full-text available
Introduction This is the twelfth report of the European IVF-monitoring (EIM), the ESHRE register on assisted reproductive techniques (ART) organization. This report deals with the results of treatments initiated during 2008. Methods Data were collected from existing national registries in 36 countries (3 more than in 2007) and directly entered by...
Article
Human chorionic gonadotropin (hCG) is one of the earliest signals secreted by the implanting embryo. In addition to its well-known luteotropic function in early pregnancy, hCG also acts directly on decidualizing endometrium. Recently, we demonstrated that recombinant hCG (rhCG) prevented apoptosis in decidualizing human endometrial stromal cells (H...
Article
Full-text available
The forkhead transcription factor FOXO1, a downstream target of phosphatidylinositol-3-kinase/Akt signalling pathway, regulates cyclic differentiation and apoptosis in normal endometrium, but its role in endometrial carcinogenesis is unknown. Screening of endometrial cancer cell lines demonstrated that FOXO1 is expressed in HEC-1B cells, but not in...
Article
The growth factors derived from platelets and plasma proteins mediate the wound-healing process that is characterized by the sequential migration and differentiation of several cell populations that give rise to angiogenesis, collagen synthesis, wound contraction, and re-epithelialization. To evaluate the efficacy of the blood-derived factors in wo...

Citations

... In vitro fertilization and embryo transfer (IVF-ET) is now widely used in the treatment of infertility, and the number of cycles performed in IVF is increasing dramatically worldwide. The number and proportion of FET cycles is also steadily increasing [2]. Successfully predicting the probability of pregnancy in the IVF cycle is a long-standing problem [3]. ...
... Since the birth of the first baby through in vitro fertilization in 1978 (Steptoe & Edwards, 1978), more than 5 million children have been born through assisted reproductive technologies (Adamson, 2012), an increasing number of whom are born by reproductive donation, that is, by the donation of gametes (eggs or sperm) or the hosting of a pregnancy for another woman (surrogacy; Richards, Pennings, & Appleby, 2012). Children born through egg donation lack a genetic link with their mother whereas children born through sperm donation (donor insemination) lack a genetic link with their father. ...
... Most couples with prolonged unresolved infertility eventually proceed to in vitro fertilization (defined here as IVF or ICSI) and the number of women treated in the UK has increased annually from 6184 in 1991 to 49 636 in 2013 (Human Fertilisation and Embryology Authority, 2008a, 2013a. Worldwide, by the end of 2013 over five million people were estimated to have been born as a result of IVF (Adamson et al., 2012), with the UK accounting for over 4% of this total (Human Fertilisation and Embryology Authority, 2014). ...
... The latest report of the European in vitro fertilization (IVF)-monitoring (EIM) has presented results of treatments initiated during 2010. Data is collected from existing national registries in the participating countries and directly entered by each national coordinator into the EIM database (3). ART data from the United States is also presented annually in surveillance papers (4). ...
... Commercially available formulations are purified by a variety of methods and differ in their source and biological composition. Consequently, variations in glycosylation patterns between preparations are observed that differentially activate LHCGR and display unique biological activity 69,[71][72][73][74] . While not addressed directly in this study, as neither LH nor hCG forms employed induced functional responses, the source and glycosylation status of gonadotropins should be considered when interpreting and comparing experimental observations. ...
... Platelet concentrates for medical and dental use are autogenous regenerative preparations obtained through the centrifugation of a blood sample from the patient [35]. Several in vitro studies, animal experiments and clinical studies suggest that platelet concentrates have certain properties which effectively trigger the stimulation of soft tissue regeneration and bone healing, and also act to reduce inflammation, pain and side effects [18,23,[36][37][38][39][40]. ...
... The FOXO family, including FOXO1, is a key effector of phosphoinositide 3-kinase (PI3K) deregulation since it is a direct downstream phosphorylation target of the protein kinase PKB and the related kinase SGK1 37 www.nature.com/scientificreports/ of the PI3K/PKB signaling pathway 39 . Incidentally, FOXO1 is upregulated by progestin in a PR-B-dependent manner, and it is involved in cell cycle inhibition, apoptosis, and inhibition of migratory and invasive capacities in endometrial cancer [40][41][42][43] . Although the crosstalk between FOXO1 and PR is not strictly ligand-dependent, this crosstalk is important for decidualization as well as the induction of apoptosis 44,45 . ...