O. A. T. Ebuehi's research while affiliated with University of Lagos and other places
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Publications (7)
Alafia barteri (Apocynaceae) is a climbing shrub having white or pink flowers. Traditionally, it has been used to treat diseases like malaria, sickle cell anemia, and eye infections. This research is focused on investigating the antioxidant and anti-arthritic activities of the aqueous and ethanol leaf and root extract of Alafia barteri plant in vit...
Alafia barteri leaves are valued for its efficacy in the traditional medicine system in Nigeria. It has been used over the years for the treatment of various diseases some of which include malaria, sickle cell anaemia, and eye infections. This has necessitated the evaluation of its chemical composition to ensure its safety for human use. This study...
Animal model development of alcohol administration in rats is of crucial importance as it gives indirect information to effects of alcohol in humans. An indirect assessment of this would be the biochemical and histological data that could arise from such experiments. 20 Male Wistar rats weighing (63.50±3.79 g), were divided into four groups (consis...
Currently, the development of natural anti-inflammatory drugs for prevention or treatment of inflammatory diseases is receiving increasing attention.
Medicinal plants are the main sources of chemical substances with potential therapeutic effects and many of compounds from plants have already been characterized. The aim of this study was to determi...
Alcohol consumption is readily acceptable worldwide, and despite warnings and billions of dollars spent yearly on its deleterious effects; people still to the present day take copious amounts of it. The study investigated the comparative effects of pure and alcoholic beverages on Wistar rats to ascertain their level of safety. Thirty five male albi...
Background: Tetrapleura tetraptera fruit is widely used in Southern Nigeria for a range of pharmacological actions. Methodology/Principal Findings: In this study, the cytotoxic and antiproliferative effects of the ethanolic extract of fruit were studied in vitro and in vivo by using ehrlich ascites carcinoma cells and tumor modelling, respectively....
Citations
... The vascular congestion observed in the kidneys of this study was in accordance with the findings of these scientists (24) in which the histopathology results of rat renal sections exposed repeated to Fijk herbal revealed compromised cellular integrity leading to swollen renal tubules, severe nephritis, hypochromic and necrosis. Also, the findings in this publication (25) showed that kidney tissues exposed to moderate ethanol showed sloughing off of cells that line tubules with some ghostlike appearance of the tubules causing acute tubular necrosis. Some scientists reported that moderate ethanol intake leads to expansion of the kidney tissue which is followed by congested glomeruli, mononuclear cellular infiltration which are features of mild nephritis that caused kidney tissue damage (26). ...
... At 40% ethanol administration, the rats showed biochemically significant decrease in serum gamma glutamyl transferase (GGT), serum aspartate (AST) and Alanine amino transferase (ALT) when compared to normal study while 5% and 15% ethanol administered rats were comparable with control values i.e. normal study. Probic evaluations such as body weight, water intake and food Dawodu et al.; ARRB, 32(6): 1-8, 2019; Article no.ARRB.48346 2 intake showed percentage decrease in 40% ethanol administrated rat when compared with controls. ...
... μg/mL. Though the pod and stem bark showed reduced inhibitions against the cell line, they have been reported to have promising cytotoxic properties against tumors and other cancer cell lines [30][31][32]. It's entirely conceivable for a substance to have effect on one type of cancer but not on others. ...