Norman M. Kaplan’s research while affiliated with The University of Texas at Dallas and other places

... Lacidipine acts by relaxing arteries, allowing blood to flow more freely, thereby decreasing blood pressure. It has low oral bioavailability (10%) due to first-pass metabolism [6]. A novel delivery system must be developed to improve bioavailability and deliver the drug in effective concentrations. ...

Reference:

DEVELOPMENT OF LACIDIPINE TRANSFEROSOMAL FORMULATIONS FOR TRANSDERMAL DELIVERY: IN VIVO CHARACTERIZATION IN RATS

... [4][5][6] Later, studies revealed and recommended to use the captopril over nifedipine due to the harmful and deadly effects of nifedipine including sudden fall in BP, brain and heart ischemia, and sudden death. [6][7][8][9] In several studies, the effect of 25 mg sublingual captopril on lowering BP has been compared with 10 mg of sublingual nifedipine, which had approximately the same effect on lowering BP; however, no significant side effects were observed with sublingual captopril. Nifedipine lowers BP faster than captopril, which causes side effects. ...

Reference:

Comparison of midazolam versus captopril in patients with uncomplicated hypertensive urgency in emergency ward: Double-blind randomized clinical trial

... In addition to its preservative effect, NaCl plays two important roles in food. Kaplan (2000), points out that a person needs 2.4 g of sodium, that is, 6 g of NaCl per day. ...

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CHEESE WITH REDUCED SALT CONTENT

... The ACC/AHA [45] was the only guideline body to recommend a target SBP less than 130 mmHg for older patients, and individualized decisions regarding BP-lowering intensity if high burden of comorbidity and limited life expectancy. The Malaysian [48] CPG recommend this goal for fit [65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80] year-olds, otherwise they suggested a SBP less than 140 mmHg or less than 150 mmHg for patients 80 years or older. NICE [42] also divides its recommendations for patients less than 80 and at least 80 years old, recommending BP less than 140/90 mmHg and BP less than 150/90 mmHg, respectively. ...

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Guidelines for hypertension management in primary care: is local adaptation possible?

... Situating this act of consuming unstandardized foods and water, Kaplan (2016) states that: ...

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Known and anticipated medical geology issues in Ghana

... While genetic testing quickly deals with the first issue, and CT scanning the third, it is the differentiation of unilateral from (non-FH-I) bilateral PA that poses the greatest challenge. It has been argued that, given the effort and expense involved in the diagnostic workup for PA (and especially subtype differentiation), consideration should be given to using spironolactone or eplerenone as first line agents in every patient thought to have PA (255,257) and even in all new hypertensives (160,162). However, this approach would mean that the 30% or so patients with PA who have unilateral forms would be denied the opportunity to undergo surgery and thereby experience a surgical cure and, in terms of both cardiovascular outcomes (81,504) and quality of life (9), superior benefits to those observed with medical therapy in bilateral PA. ...

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Primary Aldosteronism: Changing Definitions and New Concepts of Physiology and Pathophysiology Both Inside and Outside the Kidney

... Algunos subtipos de asma u otras enfermedades relacionadas, cuando se asocian con el asma pueden favorecer la aparición de un ADC. Entre éstos se encuentra el inducido por intolerancia a los AINE, el de riesgo vital, el del anciano, el corticorresistente, la aspergilosis broncopulmonar alérgica (ABPA), el síndrome de Churg-Strauss (SCS), el hipertiroidismo y el reflujo gastroesofágico [253][254][255] (evidencias B y C). El abordaje diagnóstico del ADC de forma protocolizada puede ayudar a determinar dichos subtipos 256,257 . ...

Reference:

Guía Española para el Manejo del Asma

... Although various risk factors for the development of CAN have been identified, its pathogenesis is incompletely defined (for an excellent article on this subject, please refer to [13]). Both alloantigen-dependent and alloantigen-independent mechanisms are thought to play a part in the pathogenesis of the condition [12][13][14][15][16][17][18][19] (Table 1). Pilmore and Dittmer's study, reported in 2002, showed that chronic CyA toxicity (defined as extensive arteriolar hyalinosis and obliteration), though frequently colocalizing with glomerular and interstitial fibrotic changes, was a separate entity, and although renal function deteriorated progressively in patients with or without chronic vascular changes, those patients with chronic vasculopathy due to CNIs responded almost uniformly favorably to reduction in calcineurin inhibitor exposure [22]. ...

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What we CAN do about chronic allograft nephropathy: Role of immunosuppressive modulations

... This understanding formed the basis for the clinical application of anti-estrogens, which compete with estrogen for binding to the estrogen receptor (ER) and block hormone-responsive breast cancers [Jordan et al., 1978]. Anti-estrogens can also decrease breast cancer incidence in certain highrisk populations [Osborne, 1999;Jordan, 2000;Yardley, 2000]. ...

Reference:

Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase

... Outcomes research provides evidence of health care practices and interventions in terms of, for example, the ability to function, or the level of pain, the costs or the risks involved in undergoing a surgical procedure [18]. Outcomes research ties patient experience to the type of treatment they receive. ...

Reference:

Methodological aspects of outcomes research