Noriyuki Nakanishi's research while affiliated with Osaka City University and other places

Publications (101)

Article
The association of social relations with mortality was studied over a 54-month period in 535 older Japanese people living alone. Sex-specific proportional hazard analyses indicated that finding it difficult to establish and maintain relationships with other people was significantly related to mortality, regardless of age, general health status, his...
Article
To examine the factors associated with social participation and to determine whether social participation is predictive of mortality, a cohort of 1405 randomly selected older people aged 65 years and over, living in Settsu, Osaka Prefecture, was followed up for 66 months. By multivariate analysis using logistic regression, female sex, older age, di...
Article
Seven hundred and forty seven elderly people aged from 65 to 98 (209 male and 538 female) admitted to the Geriatric Health Service Facility were evaluated with pure-tone audiometry, Office of Population Censuses and Surveys (OPCS) personal care severity score, OPCS hearing severity score, Mini-mental State Examination (MMSE) and Self-rating Depress...
Article
Nine hundred and eighteen people aged 40 years and over were examined to assess the relationship between self-reported hearing difficulty and hearing impairment at 1 kHz and 4kHz during annual health check-ups. After adjustment for potential confounding factors of self-reported hearing difficulty such as age, sex, noise exposure, ear disease and ti...
Article
To evaluate the outcome and the factors concerned with of out-of-hospital cardiac arrest patients according to the location of the collapse. From May 1st, 1998 to April 30th, 2001, 15,211 consecutive out-of-hospital cardiac arrest cases considered for resuscitation were recorded. Of these cases 7540 arrests in subjects aged 18 years or older with c...
Article
To investigate the association between fasting glucose and C-reactive protein (CRP), we examined 1715 Japanese individuals (723 men and 992 women) aged 40-69 years who did not have medication for hypertension, diabetes, or dyslipidemia, a history of cardiovascular disease or CRP levels>10mg/l. There was a statistically significant unadjusted correl...
Article
To investigate the association between C-reactive protein (CRP) and insulin resistance. This study included 1,624 Japanese participants (652 men and 972 women) aged 40 to 69 years who were non-diabetics or did not have medication for hypertension or dyslipidemia, a history of cardiovascular disease or CRP levels >10 mg/l. Serum CRP level, fasting g...
Article
Using a modified National Cholesterol Education Program (NCEP) definition of the metabolic syndrome (MS) with body mass index instead of waist circumference, we examined the associations of the MS with the risk of developing ST-T abnormalities in 3405 Japanese men aged 35-59 yr who did not have a history of cardiovascular disease or ST-T abnormalit...
Article
To examine the association between cigarette smoking and the risk of the metabolic syndrome (MS), 3649 Japanese male office workers aged 35-59 yr who did not have a history of cardiovascular disease were enrolled in this study. 2994 men without the MS at entry were followed up over a 7-yr period. A modified National Cholesterol Education Program de...
Article
The gender differences in the association between C-reactive protein (CRP) and features of the metabolic syndrome (MS) need to be elucidated among Japanese. The study population included 715 men and 988 women aged 40-69 years who were not taking anti-hypertensive, lipid-lowering, hypoglycemic, anti-thrombotic, or non-steroidal anti-inflammation med...
Article
To investigate the relationship of self-reported hearing difficulty with hearing in the worse ear and the better ear at 1 and 4 kHz. Receiver-operating characteristic (ROC) curve analysis in community-residing population. The Settsu City Health Center (Osaka, Japan). A total of 919 consecutive participants who were provided health check-ups. Compar...
Article
To investigate the association between brachial-ankle pulse wave velocity (baPWV) and metabolic syndrome (MS), we examined 374 men and 622 women aged 40 to 69 years who did not have a past history of either coronary heart disease or stroke. We used a modified National Cholesterol Education Program definition of MS that utilizes body mass index inst...
Article
Although previous studies suggest that physical activity may reduce the risk of hypertension, the role of daily life activity in the development of hypertension remains unclear. The study population included 2548 Japanese male office workers aged 35 to 59 years, who were without hypertension (systolic blood pressure [SBP] <140 mm Hg, diastolic bloo...
Article
To examine the relationship between self-assessed masticatory disability and mortality. Prospective. Community based. Total of 1,405 randomly selected people aged 65 and older living in Settsu, Osaka Prefecture, in October 1992. Data on health status as indicated by disability scores, history of health management, self-assessed masticatory ability,...
Article
Health conditions are changing rapidly in aging societies and an essential health service by municipal governments is to promote the utilization of health notebooks in support of the health of individuals. The objective of this study was to clarify the relationship between utilization of health notebooks and rates for elderly among Japanese municip...
Article
To examine the relationship between masticatory disability and mortality in a communityresiding elderly population, 1, 245. randomly selected people aged 65 years and older were following over 9 year period (398 deceased and 847 alive) . Data on health status as indicated by disability scores, history of health management, psychosocial conditions w...
Article
The aim of this study was to investigate the association between daily life activity and risk of developing diabetes. The study population included 2924 Japanese male office workers aged 35 to 59 years who did not have IFG (fasting plasma glucose level 6.1-6.9 mmol/l), type 2 diabetes (fasting plasma glucose level > or =7.0 mmol/l and/or medication...
Article
To examine age-related change in the strength of the association of white blood cell count (WBC) with features of the metabolic syndrome (MS), body mass index, blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, fasting plasma glucose, and uric acid were assessed as the components of the MS in 5,218 Japanes...
Article
To investigate the association between serum gamma-glutamyltransferase (GGT) and risk of metabolic syndrome and type 2 diabetes in Japanese male office workers. This study included 2,957 metabolic syndrome-free men and 3,260 nondiabetic men aged 35-59 years who did not have medication for hepatitis, alanine aminotransferase (ALT) levels higher than...
Article
To determine whether the clustered features of the metabolic syndrome precede the 7 year incidence of cardiovascular disease (CVD) and type 2 diabetes, we examined 6182 Japanese male office workers aged 35-59 years without any history of CVD. The 5588 subjects without type 2 diabetes also constituted the nondiabetic cohort, and were re-examined ove...
Article
To investigate the association between haematocrit and risk of development of diabetes. Methods The study enrolled 2953 normoglycaemic [fasting plasma glucose (FPG) < 6.1 mmol/l and taking no hypoglycaemic medication] Japanese men aged 35-59 years and free of medication for hypertension and history of cardiovascular disease. FPG was measured at per...
Article
All Japanese municipal governments have a responsibility to conduct a medical examination for their residents aged 40 or more under the Health Services for the Elderly Act since 1984. According to the results of the medical examination, municipal governments should give appropriate follow up services to all users. The objective of this study was to...
Article
To investigate the effects of the clustering of components of the metabolic syndrome (MS) on development of diabetes, we examined 3298 Japanese male office workers aged 35-59 years who did not have type 2 diabetes (a fasting plasma glucose level of > or =7.0 mmol/l or receipt of hypoglycemic medication) or a history of cardiovascular disease. Fasti...
Article
Nine hundred and eighteen people aged 40 years and over were examined to assess the relationship between self-reported hearing difficulty and hearing impairment at 1 kHz and 4kHz during annual health check-ups. After adjustment for potential confounding factors of self-reported hearing difficulty such as age, sex, noise exposure, ear disease and ti...
Article
Major risk factors associated with hypertension (a family history of hypertension, obesity, diabetes mellitus, hypercholesterolemia, hypertriglyceridemia, hyperuricemia, and increased white blood cell counts) were assessed in 5275 Japanese male office workers aged 23-59 years. After controlling for potential risk factors of hypertension, the odds r...
Article
The association between different features of the metabolic syndrome (MS) (obesity, hypertension, hypercholesterolemia, low high-density lipoprotein cholesterol level, hypertriglyceridemia, high fasting plasma glucose level, and hyperuricemia) and the risk for increased aortic pulse wave velocity (PWV) of > or = 8.0 m/sec was examined in 2431 Japan...
Article
To investigate the association between serum gamma-glutamyltransferase (GGT) and risk for development of diabetes. Longitudinal study (followed from 1994 to 2001). A work site in Japan. A total of 2918 Japanese male office workers aged 35-59 years who did not have impaired fasting glucose (IFG) (a fasting plasma glucose concentration of 6.1-6.9 mmo...
Article
To determine effective interventional targets for out-of-hospital cardiac arrests by analyzing the distribution characteristics of arrest patients according to age and sex with special emphasis on ventricular fibrillation (VF). All patients who suffered out-of-hospital cardiac arrest in Osaka Prefecture, Japan during 2 years, were prospectively rec...
Article
Obesity, hypercholesterolaemia, low high-density lipoprotein cholesterol levels, hypertriglyceridaemia, high fasting plasma glucose levels, hyperuricaemia and increased white blood cell count levels are all positively associated with the risk of hypertension, but the effect of the clustering of these risk factors on the risk for development of hype...
Article
We assessed the association of lifestyle factors with white blood cell (WBC) count in 3681 Japanese male office workers aged 35-59 years. The WBC count differed significantly across lifestyle factors (overall obesity, alcohol consumption, cigarette smoking, eating breakfast, nutritional balance, physical exercise and hours of work). From multiple l...
Article
We evaluated the association between changes in psychosocial conditions (assessed In 1992 and 1998) and subsequent mortality through 2001 among 741 Japanese elderly people living in a city located on Osaka in 1992. After adjustment for potential predictors of mortality, the relative risk of mortality, compared with subjects who continued to partici...
Article
To investigate the association of alcohol consumption with white blood cell (WBC) count. Cross-sectional study. A work site in Japan. A total of 5218 Japanese male office workers aged 23-59 years who participated in annual health examinations. Subjects were classified as nondrinkers, or current drinkers who averaged <12, 12-22, 23-34, 35-45, 46-68...
Article
To investigate the association between alcohol consumption and risk for development of diabetes. We examined 2,953 Japanese male office workers aged 35-59 years who did not have impaired fasting glucose (IFG) (a fasting plasma glucose concentration of 6.1-6.9 mmol/l), type 2 diabetes (a fasting plasma glucose concentration of > or =7.0 mmol/l or re...
Article
We examined the association of serum uric acid (SUA) with development of hypertension (blood pressure > or = 140/90 mmHg and/or medication for hypertension) and impaired fasting glucose (IFG) (a fasting plasma glucose level 6.1-6.9 mmol/l) or Type II (non-insulin-dependent) diabetes (a fasting plasma glucose level > or = 7.0 mmol/l and/or medicatio...
Article
We assessed the association of white blood cell (WBC) count with different components of the metabolic syndrome (MS) in 5275 Japanese male office workers aged 23-59 years. There was a significantly crude correlation between WBC count and body mass index, systolic and diastolic blood pressures, total cholesterol, high-density lipoprotein cholesterol...
Article
A close relationship between alcohol consumption and hypertension has been established, but the effect of light to moderate alcohol consumption on blood pressure (BP) remains unclear. A total of 5275 Japanese male office workers aged 23 to 59 years partook in a survey. Subjects were classified as nondrinkers or current drinkers who averaged less th...
Article
We assessed the association of white blood cell (WBC) count with different components of metabolic syndrome (MS)-obesity, hypertension, hypercholesterolemia, low high-density lipoprotein cholesterol levels, hypertriglyceridemia, high fasting plasma glucose levels and hyperuricemia-in 5275 Japanese male office workers aged 23-59 years. After control...
Article
To investigate the association of white blood cell (WBC) count with risk of hypertension. Cross-sectional and longitudinal studies. A work site in Japan. A total of 3776 Japanese male office workers aged 23-49 years were enrolled in this study; 2900 hypertension-free [systolic blood pressure (SBP) < 140 mm Hg, diastolic blood pressure (DBP) < 90 mm...
Article
To investigate the association between white blood-cell (WBC) count and the development of diabetes, independent of cigarette smoking. We examined 2953 Japanese men who were office workers and between 35 and 59 years of age and who did not have impaired fasting glucose (IFG) (a fasting glucose concentration of 6.1-6.9 mmol/l), Type II (non-insulin-...
Article
To examine the distribution and cardiovascular risk correlates of serum triglycerides, a cross-sectional population study based on annual health examinations at the workplace was performed in 2199 young Japanese adults aged 23 to 37 years. Triglyceride levels showed significant sex (male > female) differences, and the percentages of those with high...
Article
To investigate the association between duration of overtime and the development of impaired fasting glucose (IFG) or type 2 diabetes mellitus (DM). A cohort of 1266 Japanese male office workers aged 35-59 years and free of IFG (fasting plasma glucose concentration 6.1-6.9 mmol/l), type 2 DM (fasting plasma glucose concentration of 7.0 mmol/l or mor...
Article
A 9-year longitudinal study was performed to prospectively examine the association of alcohol consumption with development of increased aortic pulse wave velocity (PWV) in 1,358 Japanese men aged 35 to 59 years with a PWV less than 8.0 m/sec and without antihypertensive medication. Three hundred fifty-nine men developed increased aortic PWV of 8.0...
Article
Background : Decreased low-density lipoprotein (LDL) cholesterol in chronic alcoholics is well known. However, the importance of light to moderate alcohol consumption is less certain.Methods: We investigated the association of alcohol intake with risk for increased LDL cholesterol over 5 years in a cohort of 933 Japanese male office workers aged 35...
Article
Decreased low-density lipoprotein (LDL) cholesterol in chronic alcoholics is well known. However, the importance of light to moderate alcohol consumption is less certain. We investigated the association of alcohol intake with risk for increased LDL cholesterol over 5 years in a cohort of 933 Japanese male office workers aged 35 to 54 years who had...
Article
To identify the factors responsible for increases in serum uric acid (SUA), a cohort of 1,312 hyperuricemia-free (SUA < 7.5 mg/dL and no medication for hyperuricemia or hypertension) male office workers aged 30 to 52 years were examined annually for 8 successive years. Subjects who were found to have become hyperuricemic (SUA > or = 7.5 mg/dL) or w...
Article
The aim of this study was to evaluate the influence of health examination provided by municipalities in Japan on the use of medical care by elderly patients aged 70 and above. The study was carried out to compare health indicators of cities with high and low usage rates for health check ups over 14 years. The indicators of health service utilizatio...
Article
To evaluate the association of long working hours with the risk for hypertension. A five year prospective cohort study. Work site in Osaka, Japan. 941 hypertension free Japanese male white collar workers aged 35-54 years were prospectively examined by serial annual health examinations. Men in whom borderline hypertension and hypertension were found...
Article
To investigate the association of alcohol intake with development of hypertension. Longitudinal study (followed from 1990 to 1999). Work site in Osaka, Japan. Japanese male office workers (n = 1,310) hypertension-free, with systolic blood pressure (SBP) less than 140 mmHg, diastolic blood pressure (DBP) less than 90 mmHg, no medication for hyperten...
Article
The association of hematocrit with development of hypertension over 9 years was studied in 784 hypertension-free Japanese men aged 40 to 59 years. The age-adjusted relative risk for hypertension above the borderline level and definite hypertension increased in a dose-dependent manner as hematocrit level increased (P for trend: 0.007 and 0.001, resp...
Article
A 9-year longitudinal study was performed to prospectively examine the association of alcohol consumption with development of aortic stiffness in 1121 aortic stiffness-free [aortic pulse wave velocity (PWV) of less than 8.0 m/sec] Japanese men aged 35 to 59 years without definite hypertension, hypercholesterolemia, or diabetes. 274 men developed ao...
Article
The association of cigarette smoking with development of hearing impairment (loss of 30 dB at 1000 Hz and 40 dB at 4000 Hz) over a 5-year follow-up was studied in 1554 non-hearing-impaired Japanese male office workers who ranged in age from 30 to 59 years. After controlling for potential predictors of hearing impairment, the relative risk for low-f...
Article
To identify the lifestyle factors responsible for increases in serum gamma-glutamyltransferase (GGT), 1014 hepatobiliary dysfunction-free (no medication for and no past history of liver disease, < or = 39 U/L of serum aspartate and/or alanine aminotransferase, and < or = 59 U/L of serum GGT) Japanese male office workers aged 35-55 years were examin...
Article
The contribution of cigarette smoking to development of impaired fasting glucose and type 2 diabetes remains unclear. To investigate the association of cigarette smoking with development of impaired fasting glucose and type 2 diabetes. Prospective cohort study. Work site in Osaka, Japan. 1,266 Japanese male office workers 35 to 59 years of age who...
Article
To determine the effects of weight variability on cardiovascular risk factors. Longitudinal study (followed from 1990 to 1998). Five-hundred and eighty nonsmoking Japanese male office workers aged 25-49 y. Baseline levels and slopes of seven selected cardiovascular risk factors (systolic and diastolic blood pressure, total and high-density lipoprot...
Article
Cross-sectional associations between lifestyle and serum lipid levels were examined in 1591 Japanese male office workers aged 35 to 59 years in Osaka, Japan. From multiple linear regression analyses, significant correlates with low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and Log triglyceride levels and the...
Article
To determine whether body mass index (BMI, kg/m2) or percentage body fat (%BF) by bioelectrical impedance analysis (BIA) better reflects the cardiovascular risk profile, we examined the associations among BMI, %BF by BIA, and cardiovascular risk factors (systolic blood pressure (SBP), diastolic blood pressure (SBP), low-density lipoprotein choleste...
Article
A large outbreak of Escherichia coli O157 infections via school lunches occurred at primary schools in 1996 in Sakai City, Japan. As many as 10,000 patients suffered from diarrhoea, haemorrhagic colitis and haemolytic uraemic syndrome (HUS). Using data on 288 inpatient school children affected by this outbreak, of whom 36 presented complete HUS and...
Article
The potential inverse association between coffee intake and serum gamma-glutamyltransferase (GGT) was examined in a cross-sectional study involving 1353 Japanese male office workers aged 35-59 years in Osaka, Japan. Those who had serum aminotransferases exceeding the normal range and/or who had been administered medical care for, or had a past hist...
Article
We examined the effect of body weight change on the modification of atherogenic risk factors in 296 middle-aged obese male office workers without medication for hypertension, dyslipidemia, hyperuricemia or diabetes mellitus. During a 1-year education program, 39.2% of the participants could reduce their weight, and the percentage of those who lost...
Article
Low-density lipoprotein cholesterol (LDLC) concentrations are most commonly estimated by the Friedewald formula [LDLC=total cholesterol (TC) - high-density lipoprotein cholesterol - triglycerides (TG)/5]. To assess the validity of the conventional indirect methods including Friedewald method for determining serum LDLC level, we analyzed 1953 serum...
Article
The association of lifestyle factors with serum gamma-glutamyltransferase (GGT) was examined in 1176 Japanese male office workers aged 40–59 years. Those who had serum aminotransferase levels exceeding the normal range and/or who took prescription medication for, or had a past history of, liver disease were excluded. From the logistic regression an...
Article
The association of coffee consumption with the development of increased serum aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) activities over 4 years was studied in 1221 liver dysfunction-free (serum AST and ALT < or = 39 IU/l and no medical care for or no past history of liver disease) Japanese male office workers aged 35 to...
Article
Body Mass Index as a Measure of Health Care for Japanese Male Office Workers: Noriyuki NAKANISHI, et al. Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine—Cross-sectional associations between body mass index (BMI) and medical test items in health examinations were examined in 2,...
Article
To clarify the effect of early fosfomycin treatment, an antimicrobial agent in common use in Japan, on children with E. coli O157 with the aim of preventing hemolytic uremic syndrome (HUS). Design: Non-randomized prospective study for development of HUS among inpatients with E. coli O157. Setting: The hospitals where the 292 inpatients were treated...
Article
The Incidence of Hyperuricemia and Correlated Factors in Middle-Aged Japanese Men: Noriyuki NAKANISHI, et al.Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2—To identify the factors responsible for increases in serum uric acid (SUA), 1,346 hyperuricemia-free (less than 7.5 m...
Article
To examine the relationship between the self-assessed masticatory disability and the health of community-residing older people. Of 1473 randomly selected people aged 65 years and older living in Settsu, Osaka Prefecture, in October 1992, data on general health status, history of health management, psychosocial conditions, and dental conditions were...
Article
Few longitudinal studies on the determinants of increase in serum uric acid (SUA) have been completed. In all, 1445 hyperuricaemia-free (<7.5 mg/dl SUA, no medication for and no past history of hyperuricaemia) male office workers aged 30-54 years of T Corporation in Osaka, Japan were re-examined for six successive years. Subjects who were found to...
Article
To examine the lifestyle factors related to the development of dyslipidemia [low-density lipoprotein (LDL) cholesterol ≥ 150 mg/dL, high-density lipoprotein (HDL) cholesterol < 40 mg/dL, or triglyceride ≥ 250 mg/dL], 979 dyslipidemia-free Japanese male office workers aged 35 to 54 years were followed up for four years. The numbers of new incidence...
Article
To examine the relationship between incontinence and mortality in elderly people living at home. Of the randomly selected people aged 65 years and older living in Settsu city, Osaka in October 1992, 1405 were contacted and constituted the study cohort. Follow-up for 42 months was completed for 1318 (93.8%; 1129 alive, 189 dead). Data on general hea...
Article
Cross-sectional associations between lifestyle factors [cigarette smoking, alcohol intake, overall obesity indicated by body mass index (BMI), eating breakfast, snacking between meals, considering nutritional balance, coffee drinking, physical exercise, and hours of work and sleep] and serum lipid and lipoprotein levels were examined in 1580 middle...
Article
Cross-sectional associations between biological, clinical and behavioral factors and serum uric acid (SUA) levels were examined in 2,438 Japanese male office workers aged 20 to 59 years in Osaka, Japan. Stepwise regression analysis for SUA was carried out for all persons and repeated excluding those under medication for hypertension, hyperuricemia...
Article
The association of lifestyle factors with the development of hypertension (blood pressure ≥ 140/90 mmHg) over a 3-year follow-up period was studied in 949 hypertension-free Japanese male office workers aged 35 to 54 years. From the Cox proportional hazards model, age, alcohol intake, body mass index (BMI) and hours of work were independent factors...
Article
We examined the relationships between preventive health services provided under the Law for Health and Medical Services for the Elderly and the use of inpatient and outpatient care by insured residents aged 40 or older covered by the National Health Insurance in 44 municipalities in Osaka Prefecture. Factor analyses showed that hospital admission r...
Article
To examine the factors associated with cause-specific mortality, a cohort of 1,405 randomly selected elderly people aged 65 years and over living in Settsu, Osaka Prefecture, was followed up for 54 months. Multivariate analysis using Cox proportional hazards model identified male sex, age, disability, medical treatment, and no participation in soci...
Article
To examine the prevalence of intellectual dysfunctioning and its correlates in community-residing elderly people, a randomly selected sample of 1,405 people aged 65 and over living in Settsu, Osaka, were investigated in October 1992. Data for assessing intellectual dysfunctioning were obtained from 1,364 people (97.1%), excluding 21 clinically deme...
Article
To examine the risk factors related to the incidence of aortic stiffness, 1,045 Japanese men aged 40 to 54 years with aortic pulse wave velocity (PWV) of less than 8.0 m/sec were followed up for seven years with annual examinations, with an average period of observation of 6.3 years with standard deviation of 1.56 years. Subjects who showed 8.0 m/s...
Article
To identify the factors related to the development of hypertension on the basis of annual health examinations at the workplace. A cohort of Japanese male office workers who were reexamined for six successive years after their initial examinations in 1990. The study cohort comprised 1089 hypertension-free subjects aged 30-54 years. Six-year follow-u...
Article
To examine the relationship between intellectual dysfunctioning and mortality in a community-residing older population. Of the 1473 randomly selected people aged 65 years and older living in Settsu, Osaka Prefecture, in October 1992, 1405 were contacted. Data for assessment of intellectual dysfunctioning were obtained from 1383 people (98.4%), who...
Article
Objective: To identify the factors related to the development of hypertension on the basis of annual health examinations at the workplace. Setting: A cohort of Japanese male office workers who were reexamined for six successive years after their initial examinations in 1990. Subjects: The study cohort comprised 1089 hypertension-free subjects aged...
Article
The objective of this study was to determine whether there is an association of mortality with the type of household in elderly people. A cohort of 1,352 elderly people aged 65 years and over at baseline in October 1992 was followed for 42 months. Follow-up was completed for 1,266 (93.6%) (172 deceased and 1,094 alive). From the analysis using the...