Noo Li Jeon's research while affiliated with Seoul National University and other places

... This advanced technology recapitulates many features of the complex human tumor/host microenvironments by controlling biophysical and biochemical factors in on-demand manners, which enables the reconstitution of key biological processes and disease states (14)(15)(16). Numerous reviews have summarized the advances in tumor-on-a-chip models (17)(18)(19)(20)(21)(22)(23). Here, we focus on processes occurring in the metastatic site utilizing microfluidic vascular models (Table 1). ...

... In the 3D model, treatment with TGF-ß1 significantly increased the formation of thick lines in endothelial cells; these changes were partially reversed by the TGF-ß1 inhibitor treatment. The authors further found a higher expression level of interleukin (IL)-1ß, fibroblast growth factor (FGF)-2, TGF-ß2 and TGF-ß3 in the 3D model, while the expression of TGF-ß1 was similar in comparison to the 2D model [6]. In conclusion, this newly established 3D model might be suitable for studying fibrosis in renal segments, but further confirmatory studies are required. ...

... Thus, the urinary glycoprotein Dickkopf-3 (DKK3), whose secretion occurs stress-induced by tubular epithelial cells [11], might represent an interesting protein which may provide insights into ongoing tubulointerstitial fibrosis. DKK3 has profibrotic properties, e.g., modulating the Wnt/β-catenin signaling pathway, stimulating the expression of transforming growth factor-β (TGF-β), influencing local T-cell response, activating myofibroblasts and driving epithelial-to-mesenchymal transition [11][12][13][14][15]. Since DKK3 is expressed in tubular cells after injury, urinary DKK3 (uDKK3) might serve as a marker for ongoing tubular stress and CKD progression [11,16]. ...

... A characteristic example is the mRNA of the immediate-early gene Arc/Arg.3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1), which precisely localizes in the dendritic spines of recently activated synapses (Steward et al., 1998;Dynes & Steward, 2012). Interestingly, local dendritic regulation of mRNA levels of Arc and the 5 AMP-activated protein kinase (AMPK), by a nonsense-mediated mRNA decay mechanism, regulates the surface levels of the glutamate receptor GluR1 during synaptic plasticity (Notaras et al., 2018). These findings further reveal diverse mechanisms through which Arc functions as a 'master regulator' of synaptic plasticity (Bramham et al., 2010). ...

... Reprogramming, or the de-differentiation of mature cells to the totipotent stem-cell like state via genetic or epigenetic mediation (Takahashi and Yamanaka, 2006), is a potent tool for achieving tissue engineering and repair in various degenerative diseases, especially neurological disorders. Schwann cells (SCs) are glial cells that have the ability to repair damaged peripheral nerve myelin sheath ( Baron-Van Evercooren et al., 1997, Hyung et al., 2018, and can theoretically be reprogramed for potential clinical applications. Although the Simian virus 40 T antigen (SV40T) is routinely used to construct immortalized cell lines (Kaiser et al., 2017), it can induce cell transformation depending on the host cell type (Wang et al., 2014). ...

... Patel et al. [201] described the GRP78-targeting siRNAs self-assembled into nanostructures which exerted the GRP78 knockdown-associated cytotoxic effects on triple negative breast cancer-derived MDA-MB-231 cells in vitro. A model system for co-delivery of camptothecin and GRP78-targeting siRNA was developed on the basis of 1,2-dioleoyloxy-3-trimethylammoniumpropane (DOTAP) liposomes [202]. Those DOTAP liposomes ensured the greater efficiency of transfection (as compared to the popular lipofectamine technique) and also conferred the increased sensitivity to camptothecin in breast cancer MCF-7 cells and CSCs [202]. ...

... Cancer cannot be examined as a collection of homogenous neoplastic cells, but as a complex multicellular system in order to fully depict the interactions between malignant and nonmalignant cells, according to the most recent study. In particular, this is true as our knowledge of cancer continues to grow [242,243]. According to cancer biology's tumor-stroma interaction, this contact between the tumor and the surrounding stroma is crucial to distinguishing the tumor-stroma interaction from other interactions in cancer biology (TMI). ...

... The tumor microenvironment (TME) is regarded as a critical feature of tumors because it participates in cancer development and progression [1]. It comprises a milieu of various cells (e.g., surrounding blood vessel cells, fibroblasts, immune cells and cancer stem cells) and even noncellular components (e.g., the extracellular matrix (ECM)) [2][3][4]. The interplay among various components within the TME induces growth signaling, intermediate metabolite production, and promotes a favorable environment for tumor cells to proliferate and metastasize [1]. ...

... Recently, QD-based multiplex imaging in conjunc- tion with acousto-optic tunable filters (AOTF) was reported by Song's group to investigate multiple signal molecules using only a small number of fixed cells 33 . As shown in Figure 3, six different signaling proteins including peroxisome proliferator-activated receptor gamma (PPAR-?), phosphorylated c-Jun N-terminal kinase 1 (p-JNK-1), phosphorylated glycogen synthase kinase 3? (p-GSK3?), phosphorylated insulin receptor substrate-1 at the serine residue (p-IRS1ser), phosphorylated forkhead box protein O1 (p-FOXO1), and phosphorylated insulin receptor substrate-1 at the tyrosine residue (p-IRS1tyr) were simultaneously observed at the single-cell level to monitor obesity-induced insulin resistance between adipocyte and HepG2 cells. ...

... Several types of research have been conducted towards the design development of artificial cilia sensors [48,[142][143][144][145][146][147][148][149][150][151][152]. The artificial cilia sensors were designed to be used in the marine system's sensors [153,154], flow sensors [48,155,156], force sensors [150], and tactile and texture sensors. ...