Nobuko Taguchi's research while affiliated with SickKids and other places

Publications (11)

Article
Full-text available
Background: Risk assessment of the use of quetiapine during breastfeeding is challenging owing to a paucity of data. Methods: A pharmacokinetic study was conducted in lactating women who were taking quetiapine. The primary endpoint was to determine quetiapine concentration profiles in milk and estimated infant exposure levels. Multiple milk and...
Article
Full-text available
A 27-year-old woman with upper mediastinum stage IIA Hodgkin lymphoma was treated with six cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy. Two months later she received a total of 4,250 cGy to the upper mediastinum and left clavicular region over a 1-month period. One week after completion of radiotherapy she was found...
Article
The safety of bisphosphonates in human pregnancy has not been well established. To characterize pregnancy outcome in women receiving bisphosphonates, we conducted a multi-centre, prospective cohort study with a comparison group. Patients were recruited through 3 teratogen information centres in Canada and South Korea. We followed 21 women exposed t...
Article
Severe exacerbation of chronic neuropathic pain often requires morphine in patients already treated with drugs such as tricyclic antidepressants, carbamazepine and gabapentin. However, it is unclear if a combination of these drugs intensifies the effects of morphine on the respiratory system and, if so, whether these effects are due to pharmacokine...
Article
Use of HMG-CoA reductase inhibitors (statins) is becoming increasingly common. However, a recent study based on a series of cases reported to FDA suggests possible teratogenic effects of statins on embryogenesis, such as limb defects and severe central nervous system anomalies. In a prospective, observational cohort study with a comparison group to...
Article
Background: Since HMG-CoA reductase inhibitors (statins) are widely used for the treatment of hyperlipidemia in women of childbearing age, the pregnancy safety data regarding statins are urgently needed. Recent case series based on voluntary reports described cases of malformations including central nervous system defects and unilateral limb defect...
Article
Question: One of my male patients is receiving ribavirin-interferon alpha 2B (Pegetron) combination therapy for chronic hepatitis C. His wife recently found out she is 6 weeks pregnant. They are concerned that the medications might have affected his sperm. How should I advise them? Answer: To the best of our knowledge, paternal exposure to ribav...

Citations

... Aspirin therapy is not routinely used for primary prevention in patients with diabetes [102] . The management of myocardial infarction in pregnancy is similar to the nonpregnant state except that ACE-I and ARBs and statins are not used [103, 104]. Hyperlipidemia Patients with uncomplicated T1DM who are not pregnant have similar lipid profiles to patients without diabetes [105, 106]. ...
... Subsequent follow-up reports showed a 3.8% rate of congenital anomalies in the exposed group similar to the 3% background population rate, with no specific pattern of anomalies identified [56]. In addition, a prospective observational cohort study by the Motherisk program in Toronto did not find any malformation patterns or increased malformations in infants of 64 women with first trimester exposure to statins compared with women without exposure to known teratogens [57]. ...
... The fertility status of survivors is not well known [3,9], and some studies indicate that survivors may be unaware they may have impaired fertility because of their cancer treatment [10,11]. Other research reports that some survivors believed they were permanently sterile and then unintentionally became pregnant or impregnated their partner [12][13][14]. ...
... A 2011 literature review including 78 women exposed to bisphosphonates either before or during pregnancy concluded that, in most cases, there was no evidence of significant harm to mother or foetus [52]. However, a handful of cases of shortened gestational age, low birthweight and transient neonatal hypocalcaemia were observed [52][53][54]. In the context of PAO, Vujasinovic et al. reported a case of PAO in a 42-year-old woman treated with cyclical etidronate. ...
... This "left shift" in analgesia may not lead to greater clinical utility of the combination of morphine and amitriptyline. In rabbits, pretreatment with amitriptyline increases morphine-induced hypercarbia through pharmacodynamic processes (Kozer et al. 2008). ...
... Dabei kam es zu elektiven Schwangerschaftsabbrüchen, spontanen Aborten, der Geburt gesunder Kinder und unbekannten Verläufen [373 -376] (IV). Bei Eintritt einer Schwangerschaft unter der Behandlung der Schwangeren oder des Partners sollte daher ein Schwangerschaftsabbruch erwogen werden, wobei insbesondere bei einer Ribavirin-Therapie des Partners ein Fortführung der Schwangerschaft unter engmaschigen Kontrollen ebenso möglich ist[377,378] (IV). Zur Therapie mit Interferon alpha und/oder Ribavirin während der Stillzeit liegen keine Berichte vor und es ist nicht bekannt, inwieweit die beiden Substanzen oder deren Metabolite in die Muttermilch übergehen. ...
... BZE: 0.002-0.036 (n = 1, 2-year-old girl child) [77] Chronic consumer COC: 0.5-242; BZE: 0-71.3 (n = 48) [78] 1-2 times/month [79] Mean COC: 4; BZE: 0.6 (n = 31 Caucasians) Mean COC: 15; BZE: 1.8 (n = 51 Africans) 2-4 times/week [79] Mean COC: 19; BZE: 3 (n = 31 Caucasians) Mean COC: 33; BZE: 4 (n = 51 Africans) Daily use [79] Mean COC: 40; BZE: 6 (n = 31 Caucasians) Mean COC: 61; BZE: 6 (n = 51 Africans) COC: 0.6-2.5; BZE: 0.2-1.9 ...