Nina Otberg's research while affiliated with Moses-Mendelssohn-Zentrum Potsdam, Germany and other places

... The link between androgens and hair loss is known and recently has come into more focus in the era of COVID-19 and hair loss due to the fact that Coronavirus appears to elicit androgenic responses [4,5]. Hair loss can be triggered by drugs and radiation as well as hormonal imbalance [7,8]. ...

... e maintenance dose varies between individuals and usually ranges from biweekly to bimonthly treatments. [13] is maintenance has to be continued as long as patient requires it to remain in remission. ...

... 5,12,16 Similar to other chemotherapeutic agents, it is thought to cause alopecia through anagen effluvium because of its cytostatic effects. 19 It Figure 2 The occurrence of skin hyperpigmentation 1 month after initiation of the hydroxyurea generally presents on the scalp and may be partial or diffuse. 5,12 Although one study reported an average latency period of 8 weeks, it has also occurred several years after HU therapy. ...

... The basis for the diagnosis of alopecia, including non-scarring alopecia, are clinical presentation and trichoscopy, while in doubtful situations a biopsy should be taken for histological examination [6,7]. Trichoscopy, or dermoscopy of hair and scalp, is a non-invasive diagnostic method in which a hand-held dermoscope or videodermoscope is used to assess various hair disorders [8]. High-frequency ultrasonography (HF-USG) is another non-invasive diagnostic method that has been applied in dermatology for many years [9]; however, its usefulness for the assessment of different forms of alopecia has not been widely investigated; there are only single reports referring to the subject [10][11][12]. ...

... The dimensions and physiology of individual scalp hair is well known [19] but thickness of compressed hair layer will be highly related to physical characteristics. Thereby, sample size for systematic studies will be greatly affected by hair type due to worldwide variation and classification of human hair [20,21]. In such program, a map should be constructed between hair layer thickness and hair type to be assessed by objective and simple measurements to know how to design close fitting head mounted products for multiple groups with design guidelines in function of hair type rather than ethnicity [22]. ...

... Some experiments were performed recently in vivo to reveal the protection effect of administered sunscreens, but disturbing living tissue with detectors situated between epidermis and dermis. 26 The detectors collect photons coming from the horny layer into the air or epidermis. In this paper, we consider only "unshaded" effect of the horny layer with TiO 2 nanoparticles added, not taking into account deeper localized skin layers as scattering and absorbing media. ...

... It is a potent and highly sensitive selective 5α-reductase type-2 inhibitor (8) . The side effects include decreased libido in 1.8% of the recipients vs. 1.3% in the placebo group, erectile dysfunction in 1.3% of the recipients vs. 0.7% in the placebo group and decreased ejaculation volume in 0.8% of the recipients vs. 0.4% in the placebo group (8,9) . The sexual side effects are usually reversible. ...

... Therefore, samples can also be analyzed within the z-plain more conveniently and various deep sections may be obtained [174]. Consequently, the experimental setup works for in vivo determinations; for instance, Lademann et al. retraced the FP of curcumin and sodium fluorescein in human volunteers [175]. In vitro application on porcine ear skin is also applicable; for instance, Subongkot et al. determined the transfollicular penetration of sodium fluoresceinloaded ultradeformable liposomes via CLSM [176]. ...

... This led to the conclusion that the hair follicles must have been blocked by a plug that must be removed before the externally applied substance could penetrate. 11 Such a plug was successfully detected using optical coherence tomography, and it was shown that it consisted of desquamated corneocytes and dried sebum. 12 These can be easily removed by washing or mild peeling, so as to render the hair follicles receptive for penetration in the respective skin areas. ...

... Recently, cross-polarized UV reflectance imaging was reported as a further option for qualitative investigation [18,19]. For titanium dioxide containing sunscreens, light microscopy on cross sections of skin biopsies [20] or in vivo optical coherent tomography [21] allowed a rough estimation of the thickness of the layer based on the visualization of titanium dioxide particles. Most of the above-mentioned assays were done in vivo. ...