Nima Rezaei's research while affiliated with China Education and Research Network and other places
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Publications (406)
Introduction:
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia. Moreover, it is mentioned as one of the important causes of death due to heart disease, which imposes an undeniable financial burden on public health systems. Almost 1 out of 4 individuals aged 40 to 55 will experience AF at some point during their life. Increasing th...
The COVID-19 pandemic is ongoing and places a substantial burden on healthcare systems worldwide. As we further shed light on different disease characteristics, we identify more and more groups of people at higher risk of poor COVID-19 outcomes. Metabolic-associated fatty liver disease (MAFLD) (previously non-alcoholic fatty liver disease or NAFLD)...
Background:
Long non-coding RNAs (lncRNAs) have been reported to be involved in the pathogenesis of neurodegenerative diseases. It has also been hypothesized that plasma exosomal lncRNAs may be used as Alzheimer's disease (AD) biomarkers. In this systematic review, we compiled all studies on the subject to evaluate the accuracy of lncRNAs in ident...
Background:
Selective IgA deficiency (SIgAD) is the most prevalent inborn errors of immunity with almost unknown etiology. This study aimed to investigate the clinical diagnostic and prognostic values of lymphocyte subsets and function in symptomatic SIgAD patients.
Methods:
A total of 30 available SIgAD patients from the Iranian registry and 30...
The Article Abstract is not available.
Cancer is a leading cause of mortality in patients worldwide. Some types of cancer treatment are surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, etc. Therapeutic failure is a result of drug resistance in cancers and this phenomenon is the biggest obstacle in the treatment of cancers. Various mechanisms ar...
Autosomal-recessive immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is mainly determined by recurrent tract respiratory and gastrointestinal infections in early childhood due to agammaglobulinemia. Most patients with ICF syndrome die of infection at a young age, usually in the first or second decade of life. The leadi...
Background: Comprised of two main subtypes (Ulcerative Colitis (UC) and Crohn), inflammatory bowel disease is caused by an interaction between genetic and environmental factors. As of the important role of innate immunity and JAK/STAT signaling pathway, the current study was designed to investigate the methylation status JAK2 gene in blood and tiss...
Cancer immunology is among the most important disciplines of cellular and molecular immunology, and it has progressed significantly in the last decade. A tumor is a mass of tissue that develops as a result of uncontrolled cell division. The ability of tumor cells to proliferate and invade distant areas is the key feature of tumor cells. In this reg...
Objectives:
BDNF has been implicated in the pathophysiology of systemic lupus erythematosus (SLE), especially its neuropsychiatric symptoms. The purpose of this study was to investigate the profile of blood BDNF levels in patients with SLE.
Methods:
We searched PubMed, EMBASE, and the Cochrane Library for papers that compared BDNF levels in SLE...
Occupational and environmental exposures to metals are strongly associated with an increased risk of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the exact mechanisms are still ambiguous. Given the different chemical properties of metals, a uniform mechanism of action for all metals is unlikely. Recen...
Metastasis is responsible for more than 90% of cancer deaths, but remains the least understood stage of tumor progression. The tumor microenvironment contains multiple cells, including nonmalignant and malignant populations. Non-cancer populations are leukocyte infiltration, stromal cells, and vasculature expansion. The dynamic and heterogeneous in...
Inborn errors of immunity (IEI) are disorders characterized by the impaired development and functioning of the immune system components. These errors can affect cellular immunity, humoral immunity, or both, predisposing patients to localized and systemic manifestations (for the most recent update on the classification of IEI, see [1](#ref‐0001)). A...
It has been revealed that patients suffering from chronic inflammatory disorders have a much higher risk of malignancy in the affected organs. CD4+ T cells are essential for the initiation and continuation of adaptive immunity. Their role in antitumor immunity is multifaceted, reflecting the numerous effects of different kinds of them. Although Th1...
Tumor-associated macrophages (TAMs) are among the first non-tumoral cells that infiltrate the tumor microenvironment (TME) and encompass up to half of the tumor mass. Extensive research shows that increased TAM density is linked to tumor aggressiveness and poor prognosis. As growing evidence indicates the prominent role of TAMs in tumorigenesis, th...
Lung cancer is the leading cause of cancer-related death. The prognosis is poor with 5-year relative survival of about 22%. Non-small cell lung cancer (NSCLC) comprises most cases of lung cancer. The tumor immune microenvironment (TIME) plays a critical role in NSCLC. Tumor mutational burden, immunogenic versus immunosuppressive tumors, and charact...
Cancer is a leading cause of death worldwide, accounting for nearly ten million deaths in 2020. In this regard, gastrointestinal (GI) cancers are among the cancers with the highest mortality rate. In the past, surgery, chemotherapy, radiotherapy, and their combination were the only solutions for cancer treatment; however, the emergence of immunothe...
Numerous physiological samples are employed to find cancer biomarkers before the beginning of clinical signs. Different forms of cancer biomarkers may be retrieved from the tissue, blood, urine, or other body fluids, depending on the type of cancer. Over time and the discovery of new technology, numerous breakthroughs have been achieved in detectin...
OMIM: #276700 (TYPE 1)/276600 (TYPE2)/276710 (TYPE3)
The diffusion of cancer cells from the primary tumor site into a secondary organ of the body is called metastasis. Metastasis is a feature of malignant cancerous cells and is the cause of cancer treatment failure as well as most cancer-related deaths. Although many studies have been done on various aspects of the complex phenomenon of cancer metast...
High production of lactic acid is a common feature of various tumors. Lactic acid is an immunosuppressive molecule with crucial roles in tumor cells' immune escape, which could largely be attributed to its negative effects on the T cells present in the tumor microenvironment (TME). Strategies that decrease the glycolysis rate of tumor cells could e...
Immunotherapy demonstrated promising results in cancer treatment. However, its indication is restricted by low bioavailability and unfavorable side effects, including cytokine release syndrome and autoimmunity. The inadequate delivery of immunotherapeutics increased recurring administration costs and resulted in off-target toxicity. These limitatio...
Introduction
Immunotherapy is a promising and progressing treatment approach for cancer. Bispecific antibodies (BsAbs) are antibody constructs that can bind to two different epitopes. The dual-specificity of BsAbs improves their efficacy compared to monoclonal antibodies.
Areas covered
Although BsAbs have achieved excellent therapeutic effects in...
Background
DCLRE1C gene mutation leads to Artemis deficiency, a severe form of combined immunodeficiency (SCID). Impaired DNA repair and block in early adaptive immunity maturation results in T-B-NK+ immunodeficiency associated with radiosensitivity. Recurrent infections early in life are the main characteristic of Artemis patients.
Method
Among 5...
Introduction:
Echinococcosis is a chronic disease caused by Echinococcus species. The central nervous system (CNS) hydatidosis is still a major concern, especially in endemic countries, due to non-specific features and late diagnosis and treatment. This study aimed to provide a systematic review to elucidate the epidemiology and clinical character...
Cancers are the leading causes of mortality and morbidity around the world, and by improvement in the availability of screening and diagnostic methods, as well as reduction of communicable diseases and elongation of life expectancy, their incidence is increasing. Different cancers have variable behavior and will eventually cease the patients’ lives...
Vaccination is the best way to prevent and reduce the damage caused by infectious diseases in animals and humans. So, several vaccines are used for prophylactic purposes before the disease, while therapeutic vaccines strengthen the immune system after infection with the pathogen. Adjuvants are molecules, compounds, or macromolecules that enhance no...
Purpose
Primary B cell defects manifesting as predominantly antibody deficiencies result from variable inborn errors of the B cell lineage and their development, including impairments in early bone marrow development, class switch recombination (CSR), or terminal B cell differentiation. In this study, we aimed to investigate autoimmunity in monogen...
Background:
Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor expressed in several tissues, including the brain, gut, and pancreas. Activation of the BDNF/TrkB/CREB reduces hepatic gluconeogenesis, induces hepatic insulin signal transduction, and protects against pancreatic beta-cell loss in diabetes mellitus (DM). Several studies...
The ketogenic diet (KD) was initially used in 1920 for drug-resistant epileptic patients. From this point onward, ketogenic diets became a pivotal part of nutritional therapy research. To date, KD has shown therapeutic potential in many pathologies such as Alzheimer's disease, Parkinson's disease, autism, brain cancers, and multiple sclerosis. Alth...
The emergence of highly immune-escape Omicron variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), such as BQ and XBB, has led to concerns about the efficacy of vaccines. Using lentivirus-based pseudovirus neutralizing assay, we showed that heterologous vaccination involving parental mRNA vaccine as a booster or second boos...
Pheochromocytoma-islet cell tumor syndrome is characterized by the occurrence of pheochromocytoma, islet cell tumor, or both in a person, which differs from multiple endocrine neoplasia (MEN). Carney et al., in 1980, reported 3 families with 11 affected members that had pheochromocytoma or islet cell tumor, or both for the first time. Interestingly...
Melanoma is the most aggressive skin cancer whose incidence is increasing in western countries. Among novel treatments, immunotherapy has shown promising results for melanoma in recent years. Interferon-α and interleukin-2 are two cytokines, used in many old and recent studies to treat melanoma alone or in combination with other options as first-li...
An immunocompromised status has been associated with more odds of being infected with monkeypox virus (MPXV) and progressing to severe disease. This aligns with the importance of immune competence for MPXV control and clearance. We and others have previously reviewed parallels between MPXV and other viruses belonging to the Poxviridae in affecting...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment option for hereditary hemoglobin disorders, such as beta-thalassemia; However, this procedure is not without constraints, mainly engendering complications such as acute graft-versus-host disease (aGvHD), chronic GvHD (cGvHD), and susceptibility to infections. T...
Radiosensitizers are compounds or nanostructures, which can improve the efficiency of ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells to radiation‐induced killing, while simultaneously reducing the potentially damaging effect on the cellular structure and function of the surrounding healthy tissues....
Artificial intelligence (AI) happened first to medical research some decades ago; however, the progress of its application to cancer has been noticeable during the recent two decades, especially since 2017. Here, we briefly review the recently published statistical results provided by pooled analyses and meta-analyses addressing how AI has contribu...
Recently, novel cancer immunotherapy approaches have gained rising interest. While chronic inflammation has been defined as a major hallmark of malignancy, acute and targeted inflammation may be able to stimulate the immune system to treat illnesses, such as cancer. Toll-like receptors (TLRs) are innate immune receptors that act as a bridge between...
During decades of cancer research, different disciplines have made important contributions to the development of our knowledge about cancer. Identification of complex problems not being solved using a single discipline has directed scientists toward interdisciplinary approaches. Cancer is a complex problem that, regardless of great advances in diff...
Circular RNAs (circRNAs) are a class of non-coding RNAs in cells that lack a 5-terminal cap and a 3-terminal poly-A tail. These covalently closed RNA molecules are made in large numbers in eukaryotes and exhibit various roles in epigenetically changing cell functions. Recent original studies have demonstrated that the deregulated profile of circula...
OMIM: #230400 (TYPE 1), #230200 (TYPE 2), #230350 (TYPE 3), #61881 (TYPE 4)
Breast cancer is a collation of malignancies that manifest in the mammary glands at the early stages. Among breast cancer subtypes, triple-negative breast cancer (TNBC) shows the most aggressive behavior, with apparent stemness features. Owing to the lack of response to hormone therapy and specific targeted therapies, chemotherapy remains the first...
Signal transducer and activator of transcription (STAT) signaling pathway, connected upstream with Janus kinases (JAK) proteins, is known to be capable of the integration of inputs from various signaling pathways. Each family member exerts a particular role in signal transduction and is hence crucial to mediate different cellular responses to cytok...
Introduction
Genetic defects affect the manner of the immune system’s development, activation, and function. nuclear factor-kappa B subunit 1 (NF-κB1) and NF-κB2 are involved in different biological processes, and deficiency in these transcription factors may reveal clinical and immunological difficulties.
Areas covered
This review article gathers...
The optimal tumor model improves cancer diagnosis, prognosis, and therapeutics studies. In tumor modeling, it is crucial to mimic the tumor microenvironment (TME) that includes cellular heterogenicity and tumor cell communications. Traditional 2D cancer cell culture and early 3D culture had many deficiencies in imitating the genotype and phenotype...
Hyperbaric oxygen therapy (HBOT) provides patients with breathing pure oxygen under higher-than-normal air pressure. Applications of HBOT mainly occur in the management settings for the treatment of radiation-related complications. To date, lymphedema, proctitis and cystitis, and osteoradionecrosis of the jaw have been the most common conditions fo...
Female infertility is a significant health issue worldwide with a rising incidence. Anti-cancer therapy is one of the most important reasons for increasing infertility. Although anti-cancer treatment increases the rate of survival, it decreases the quality of life through its side effects. The most substantial side effects are sexual dysfunction an...
Immunotherapy, particularly immune checkpoint inhibitor therapy, has made remarkable advancements in the treatment of patients with cancer in the last decade. However, not all patients respond to immunotherapy, which is a therapeutic approach associated with high costs and adverse events. As such, there is an unmet need for identifying biomarkers t...
Background:
Glioblastoma is one of the most common malignant brain tumors in adults with poor prognosis. Neovascularization is one of the characteristics of these tumors, which is associated with overexpression of vascular endothelial growth factor (VEGF). Accordingly, single nucleotide polymorphisms of this gene could play an important role in st...
Cancer immunotherapy, which aims to eradicate tumor cells with the patient’s
own immune system, needs to be individualized the same as other therapeutic
strategies, because only a specific group of patients clinically respond to the
therapy and nonresponders are at a high risk of severe adverse effects. Therefore,
the process of trial and error for...
Previous investigations have revealed that circular RNAs (circRNAs) play pivotal roles in cancer development and progression by participating in several biological procedures, such as competing endogenous RNA (ceRNA) networks. Recently, circRNAs have been proposed as non-invasive, stable, and affordable cell-free biomarkers for cancer screening and...
Objective
We evaluate the efficacy and safety of Elotuzumab, an immunostimulatory monoclonal antibody, in combination with concomitant treatment regimens for multiple myeloma (MM) patients.
Research design and methods
PubMed, Scopus, Web of Science, and EMBASE databases were searched systematically up to August 2, 2022.
Results
Five randomized co...
Background
Cryoablation is a minimally invasive procedure to treat painful bone metastases in patients with cancer. We designed a systematic review to understand the safety and effects of cryoablation on the pain and quality of life (QoL) of cancer patients.Method
We searched PubMed, ISI, Cochrane library, and Scopus databases using the keywords “C...
Background: Leukemia is a malignant disease that threatens human health and life. Nano-delivery systems improve drug solubility, bioavailability, and blood circulation time, and release drugs selectively at desired sites using targeting or sensing strategies. As drug carriers, they could improve therapeutic outcomes while reducing systemic toxicity...
Syndrome OMIM number: #155100
Sebastian syndrome (SBS) is a rare disorder, and thrombocytopenia, giant platelets, and Döhle body-like inclusions in peripheral blood leukocytes are among its presentations clinical manifestations. Greinacher et al. in 1990 reported a family with at least six affected individuals with giant platelet syndrome, neutroph...
OSLAM syndrome is a genetic disorder defined by the occurrence of osteosarcoma, limb anomalies (clinodactyly with brachymesophalangy, bilateral radioulnar synostosis, and absence of one digital ray of the foot), and red cell macrocytosis without anemia. In 1977, Mulvihill et al. reported a family in which three of nine children developed osteosarco...
Triple-negative breast cancer (TNBC) is the subtype of breast cancer with the poorest outcomes, and is associated with a high risk of relapse and metastasis. The treatment choices for this malignancy have been confined to conventional chemotherapeutic agents, due to a lack of expression of the canonical molecular targets. Immunotherapy has been rec...
Neutrophils play an important role in human innate immunity, but their role in cancer biology was underestimated. It was seen that a high neutrophil-to-lymphocyte ratio is correlated with poor outcomes in patients with cancer. Recently, the role of neutrophils in tumor progression has been increasingly noticed. Tumor-associated neutrophils (TANs) h...
Adoptive cell therapy (ACT) is an approach for the separation and reinfusion of autologous or allogeneic cells. Non-genetically modified or genetically modified cells expressing new chimeric antigen receptors such as T cells, natural killer (NK) cells, or engineered macrophages are among the most interesting types. This technique is considered a pr...
Glioblastoma multiform (GBM) is the most prevalent and deadliest primary brain malignancy in adults, whose median survival rate does not exceed 15 months after diagnosis. The conventional treatment of GBM, including maximal safe surgery followed by chemotherapy and radiotherapy, usually cannot lead to notable improvements in the disease prognosis a...
Coronavirus disease 2019 (COVID-19) affects the respiratory system of patients and is characterized by pneumonia with hypoxemia. Hospitalized patients and particularly those admitted to intensive care unit (ICU) may encounter a cascade of coagulopathies, which may lead to macrovessel thrombotic events such as pulmonary embolism (PE), deep vein thro...
Background:
Beta-thalassemia major is an autosomal recessive disorder in hemoglobin synthesis. Ineffective erythropoiesis is the main characteristic of the disease, which results in anemia following the extensive destruction of red blood cells. Chronic antigenic stimulation following frequent blood transfusions lead to immune abnormalities, especi...
The authors of Integrated Education and Learning were asked how they would see the future of their field 30 years later. This chapter presents the authors’ views on cognitive semiotics as an integrated field of science in 2050, along with thinking skills (computational thinking, scientific thinking, and critical thinking); early childhood education...
Brain tumorBrain tumor (BT) is the second most common pediatric cancer, one of the most common cancers among adults, and the major cause of cancer-related morbidityMorbidityand mortalityMortality worldwide. Both genetics and environment can contribute to BT induction. One of the environmental risks is dietDiet which has not been proven as a certain...
As one of the global concerns, cancers, including brain and spinal cord tumors, are responsible for mortalities and irreversible morbidities in the affected patients. Although advancements in molecular pathology and imaging of tumors may have influenced the incidence rate due to higher diagnosis in early stages, exposure to environmental risk facto...
CNS tumors are a diverse group of neoplasms that emerge from a variety of different CNS cell types. These tumors may be benign, malignant, or borderline in nature. The majority of high grade glial tumors are fatal, with the exception of pilocytic astrocytoma. Primary malignant CNS tumors occur at a global annual rate of 2.1 to 5.8 per 100,000 perso...
The CNS tumors, in particular those with malignant characteristics, are prominent burdens around the world with high mortality and low cure rate. Given that, researchers were curious about novel treatments with promising effectiveness which resulted in shifting the dogmatism era of neurogenesis to the current concept of postnatal neurogenesis. Cons...
Citations
... Chemoresistance in OS immunotherapy [28] is the main problem in MBD in general and PBD in particular [29]. This problem increases after long-term treatments due to its acquired and accumulated nature [30,31]. Chemoresistance develops over time, limiting clinical application and raising concerns about efficacy and systemic toxicity [32,33]. ...
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... Adjuvant vaccine-based immunotherapy of TBNC has been recently reviewed [13]. Out of 42 clinical studies reviewed, only one limited exploratory human study [14] has targeted SVN in TBNC. ...
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... Our findings may not apply to current COVID-19 epidemiology. However, coagulopathy in COVID-19 patients is still a field of research and there is a need for more structured clinical trials to make physicians able to take precise decisions regarding thromboprophylaxis in COVID-19 patients [43,44]. In addition, the role of intermediate dose heparin thromboprophylaxis in non-critically ill patients has not been adequately studied in the available RCTs [34]. ...