Nikunj Mahida's research while affiliated with University of Nottingham and other places

Publications (43)

Article
Background: Viral sequencing of SARS-CoV-2 has been used for outbreak investigation, but there is limited evidence supporting routine use for infection prevention and control (IPC) within hospital settings. Methods: We conducted a prospective non-randomised trial of sequencing at 14 acute UK hospital trusts. Sites each had a 4-week baseline data-co...
Article
Full-text available
Background: Viral sequencing of SARS-CoV-2 has been used for outbreak investigation, but there is limited evidence supporting routine use for infection prevention and control (IPC) within hospital settings. Methods: We conducted a prospective non-randomised trial of sequencing at 14 acute UK hospital trusts. Sites each had a 4-week baseline data-c...
Preprint
Introduction Viral sequencing of SARS-CoV-2 has been used for outbreak investigation, but there is limited evidence supporting routine use for infection prevention and control (IPC) within hospital settings. Methods We conducted a prospective non-randomised trial of sequencing at 14 acute UK hospital trusts. Sites each had a 4-week baseline data-c...
Article
Full-text available
Nosocomial SARS-CoV-2 infections have severely affected bed capacity and patient flow. We utilised whole genome sequencing (WGS) to identify outbreaks and focus infection control resources and intervention during the UK’s second pandemic wave in late 2020. Phylogenetic analysis of WGS and epidemiological data pinpointed an initial transmission even...
Article
Full-text available
Infection expertise in the NHS has historically been provided predominantly by hospital-based medical microbiologists responsible for provision of diagnostic services and advice to front-line clinicians. While most hospitals had consultant-led microbiology departments, Infectious Diseases departments were based in a small number of specialist centr...
Preprint
Background Nosocomial infections have posed a significant problem during the COVID-19 pandemic, affecting bed capacity and patient flow in hospitals. Effective infection control measures and identifying areas of highest risk is required to reduce the risk of spread to patients who are admitted with other illnesses. This is the first pandemic where...
Article
Full-text available
Background Carbapenemase Producing Enterobacterales (CPE) are a global health concern. Nosocomial outbreaks have been reported globally with patient-to-patient transmission felt to be the most frequent route of cross-transmission. Aim To describe the investigation and control of an outbreak of healthcare-associated New Delhi Metallo-beta-lactamase...
Article
Congenital cytomegalovirus is the most common intrauterine infection and the leading non-genetic cause of sensorineural hearing loss. Worldwide, the birth prevalence is estimated at 7 per 1000 with the highest rates seen in developing countries. The highest intrauterine transmission rates and risk of neurodevelopmental sequelae are associated with...
Article
Antibiotic resistance is not new. However, the microbiological landscape is changing for paediatricians. Increasingly resistant Gram-negative bacteria such as Escherichia coli and Klebsiella spp. Have, historically, resulted in infections in children. More recently, carbapenem resistant Enterobacteriaceae (CRE) have emerged and they have become one...
Article
Background: Outbreaks of group A streptococcus (GAS) infections can occur in healthcare settings. Transmission to patients is sometimes linked to colonised healthcare workers and/or a contaminated environment. Aim: This report describes the investigation and control of an outbreak of healthcare-associated GAS on an elderly care medical ward, ove...
Article
Free full text available until 04/11/2016 at http://authors.elsevier.com/a/1TjPWiVN-nddj. Influenza virus infection is associated with significant morbidity and patients at risk of complicated pneumonia in the United Kingdom (UK) are offered yearly vaccination.1 Patients at risk of complicated pneumonia who develop infection due to Influenza virus...
Article
http://authors.elsevier.com/a/1TOkAiVN-nddX (Article freely available until 06/09/2016). The increase in antimicrobial resistance and its threat to the practice of modern medicine is now widely recognized as one of the most important challenges facing not only the medical profession, but society as a whole.1‒5 Antimicrobial stewardship (AMS) has t...
Article
Non-slip socks are increasingly used to prevent falls in hospitals. Patients use them to walk to various parts of the hospital and also wear them in bed. 54 pairs of socks and 35 environmental floor samples were obtained from 7 wards in a tertiary referral hospital. Vancomycin-resistant enterococci (VRE) were detected from 46 (85%) socks and metici...
Article
Background There is growing interest in the use of no-touch automated room decontamination devices within healthcare settings. Xenex PX-UV is an automated room disinfection device using pulsed ultraviolet (UV) C radiation with a short cycle time. Aim To investigate the microbiological efficacy of this device when deployed for terminal decontaminat...
Article
The mission statement, ‘To provide healthcare professionals with the information, evidence and skills they need to prevent and control healthcare-associated infections’, has provided the foundation for educational activities supported by the Healthcare Infection Society (HIS) since its formation in 1980. This is particularly relevant in the current...
Article
http://authors.elsevier.com/a/1SoCkiVN-mUNX
Article
Introduction: Neisseria meningitidis is a human pathogen with five serogroups causing the majority of invasive disease worldwide. Pharyngeal carriage of N. meningitidis is known to occur, but it is not considered a significant pathogen in skin and soft tissue infections secondary to human bites. We present a rare case of meningococcal septicaemia a...
Article
Syringes (N = 426), ventilator machine swabs (N = 202) and intravenous (IV) fluid administration sets (N = 47) from 101 surgical cases were evaluated for bacterial contamination. Cultures from the external surface of syringe tips and syringe contents were positive in 46% and 15% of cases, respectively. The same bacterial species was cultured from b...
Article
Background Outbreaks of group A streptococcus (GAS) infections may occur in healthcare settings and have been documented in surgical, obstetrics and gynaecology, and burns units. The environment may serve as a reservoir and facilitate transmission via contaminated equipment. Aim To describe the investigation and control of an outbreak of healthcar...
Article
Congenital cytomegalovirus is the most common intrauterine infection and the leading non-genetic cause of sensorineural hearing loss. Worldwide, the birth prevalence is estimated at 7 per 1000 with the highest rates seen in developing countries. The highest intrauterine transmission rates and risk of neurodevelopmental sequelae are associated with...
Article
Vancomycin-resistant enterococci (VRE) are nosocomial pathogens associated with significant morbidity in immunosuppressed patients. Stool culture is considered the gold standard for VRE screening. However, in a clinical environment, there are difficulties associated with the practicalities of obtaining stool samples. Groin swabs, routinely collecte...
Article
Tru-D™ is an automated room disinfection device that uses ultraviolet-C radiation to kill micro-organisms. The device was deployed in six side-rooms and an operating theatre. In a cleaned, unoccupied operating theatre, Tru-D eradicated all organisms from the environment. Using artificially seeded Petri dishes with meticillin-resistant Staphylococcu...

Citations

... The current evidence does not support the use of real-time genomics for control of SARS-CoV-2 nosocomial outbreaks (Stirrup et al., 2021;Stirrup et al., 2022). Nevertheless, in this investigation, as in many others, we performed WGS to investigate transmission patterns (Aggarwal et al., 2022). ...
... In the United Kingdom, in March 2020, researchers led by Sharon Peacock, with support from the UK Government's Chief Scientific Adviser Patrick Vallance, rapidly built the COVID-19 Genomics UK Consortium. It was based on existing strengths in areas such as pathogen genomics and the network of specialist academic facilities working with public health agencies and the NHS, with the MRC-funded and readily accessible cloud bioinformatics infrastructure being a particularly important facilitator [103,158,159]. ...
... Counsel patients and carers about the MRSA decolonisation regimen or antibiotics to support compliance with regimens. This should include advice about finishing the course and the disposal of unused medication [41][42][43] . (https://pharmaceutical-journal.com/article/news/iv-antibiotics-no-more-effective-thanoral-for-eradicating-infection-in-cystic-fibrosis-patients-study-suggests) ...
... It is possible to argue that surface transmission might not be as hazardous as initially thought. Nonetheless, hand hygiene is always important [18] and thus, this device presents a simple, inexpensive solution which does not require any permanent alterations to the door. The inclusion of clean filament helps stopping the transmission as it can deactivate the virus. ...
... The toilet in en suite bathrooms can be used for disposal of fluids, etc., provided the person is trained to understand the importance of minimizing the risk of splashing/aerosol generation [20]. In drug preparation area rooms, we would suggest exploring the possibility of using disposable sealable boxes containing absorbent granules. ...
... In contrast, antifungal stewardship (AFS) programs were uncommon as a component of AMS (1). During the COVID-19 pandemic, both AMS and AFS programs have lost their priority (2). ...
... All the studies included adult population aged between 18 and above 60 years. Females were observed to be affected more in 10 reviewed stud-ies 6,8,9,11,12,16,18,19,22,23 , while males predominated in other 10 studies 7,10,13,14,15,17,20,21,24,25 . The median length of hospital stay of the COVID-19 patients during the acute infection phase ranged from 8 days to 17 days (Table I). ...
Reference: Long Covid
... Surfaces contaminated with SARS-CoV-2 can effectively be disinfected within 1 min by applying at least 62% alcohol, 0.5% hydrogen peroxide or 1,000 ppm (0.1%) sodium hypochlorite [144]. Different alcohol-based hand rub formulations and lower dilutions of alcohol have also been reported to be effective disinfectants [145]. ...
... Diversos estudos abordam a relevância desta temática, demonstrando que a prática de higienizar as mãos é capaz de prevenir a transmissão de doenças infecciosas em diversos locais, como hospitais, lares de idosos, creches, escolas e ambiente de trabalho (GRAY; OPPENHEIM; MAHIDA, 2018;MBAKAYA;LEE;LEE, 2017;SAVOLAINEN-KOPRA et al., 2012;TEMIME et al., 2018;ZOMER et al., 2016). A partir do exposto, este capítulo possui o objetivo de realizar uma revisão de literatura sobre higienização das mãos, tanto ao nível hospitalar como ao da comunidade, conscientizando os envolvidos sobre sua importância. ...
... Recent reports reveal that bacteria isolated from poultry exhibit clinically relevant AMR and harbor extended-spectrum b-lactamase (ESBL) genes, carbapenemase genes, colistin resistance genes, and other plasmid-mediated quinolone genes. Over the last 2 decades, ESBL-producing E. coli isolates have been detected with increasing occurrence in human and animal samples (Boswell et al., 2018;Kawamura et al., 2018;Paitan, 2018). ESBLs induce resistance to extended-spectrum (3rd and 4th generation) cephalosporins (e.g., ceftazidime, cefoperazone, cefixime, and cefpirome) and monobactams (Pitout and Laupland, 2008;Magiorakos et al., 2012;Nicolas-Chanoine et al., 2014). ...