Nick Levy's research while affiliated with The Scripps Research Institute and other places

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Publication (1)

Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments
Article
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  • May 2015
The mitochondrial respiratory chain (RC) produces most of the cellular ATP and requires strict quality-control mechanisms. To examine RC subunit proteostasis in vivo, we measured RC protein half-lives (HLs) in mice by liquid chromatography-tandem mass spectrometry with metabolic [(2)H3]-leucine heavy isotope labeling under divergent conditions. We...
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Citations

... To assist in minimizing cellular damage and preserve homeostasis, many quality control systems, including autophagic clearance of damaged mitochondria, have been identified. Mitophagy exists at the crossroads of cell survival and death [3,36], while mitophagy failure has been linked to a variety of pathological conditions and disorders [37,38]. Mitochondria may undergo mitophagy via a variety of mechanisms, and these combinative mechanisms highlight the evolutionary significance of removing damaged mitochondria. ...
Reference: The Role of Mitophagy in Skeletal Muscle Damage and Regeneration
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