Nianxuan Wu's research while affiliated with Shanghai Jiao Tong University and other places

Publications (9)

Article
Persistent corneal epithelial defects (PED) can lead to irreversible blindness, seriously affecting the social function and life quality of these patients. When it comes to refractory PED, such as limbal stem cell deficiency (LSCD), that does not respond to standard managements, stem cell therapy is an ideal method. Oral mucosal epithelium (OME) ab...
Article
Topical drug delivery is critical for treating ocular diseases but suffers from significant defects including low drug availability, long-term frequent administration, and damage to ocular surface, which largely restrict treatment efficacy and influence quality of life. Here, we describe the formation of a durable and protective therapeutic nanocoa...
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Eyelid plays a vital role in protecting the eye from injury or infection. Inflammation related eyelid diseases, such as blepharitis, are the most common ocular disorders that affect human's vision and quality of life. Due to the physiological barriers and anatomical structures of the eye, the bioavailability of topical administrated therapeutics is...
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Purpose: This study aimed to investigate the therapeutic effects and underlying mechanisms of locally delivered regulatory T cells (Tregs) on acute corneal wound healing after alkali burn. Methods: After corneal alkali burn, the mice were injected subconjunctivally with regulatory T cells (Tregs) isolated from syngeneic mice. The wound healing p...
Article
Conjunctival restoration is indispensable to help maintain the ocular surface microenvironment by secreting lubricative mucins. However, conventional amniotic membrane transplantation therapy has many limitations in its application due to risks involved with disease transmission and alloreactivity. As decellularized tissues have been frequently use...
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Conjunctival fibrosis is a process of extracellular matrix accumulation and the appearance of myofibroblasts in subconjunctival fibroblasts induced by injury or inflammation, which can significantly reduce the filtration efficiency of glaucoma filtration surgery. In this study, autophagy was confirmed to be involved in regulating the fibrosis of hu...
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Severe conjunctival diseases can cause significant conjunctival scarring, which seriously limits eye movement and affects patients' vision. Conjunctival reconstruction remains challenging due to the lack of efficient methods for stem cells enrichment. This study indicated that p75 positive conjunctival epithelial cells (CjECs) were mainly located i...
Article
Full-text available
Tarsal plate regeneration has always been a challenge in the treatment of eyelid defects. The commonly used clinical treatments such as hard palate mucosa grafts cannot achieve satisfactory repair effects. Tissue engineering has been considered as a promising technology. However, tarsal plate tissue engineering is difficult to achieve due to its co...

Citations

... For glaucoma studies, rabbits with both normal as well as elevated IOP were used. For DED, rabbits used were pretreated topically with eye drops containing either 0.1% benzalkonium chloride (Huang et al., 2018;Chen et al., 2021) or 1% atropine sulfate in order to induce disease symptoms (Shafaa et al., 2011;Karn et al., 2014;Kang et al., 2016). Ocular inflammation in rabbits was induced with topical application of arachidonic acid (Bucolo et al., 2002;Katara and Majumdar, 2013;Sharma A. K. et al., 2016a;Sharma AK. et al., 2016b;Weng et al., 2018;Katara et al., 2019) or endotoxin (Adibkia et al., 2007a;Adibkia et al., 2007b). ...
... With the development of endoscopy, now the intra-articular injection is convenient [54]. For therapy of inflammation related eyelid diseases, the Rosiglitazone-loaded TG-18 hydrogel can be used for in situ eyelid injection with sustained therapeutics release [55]. In addition, based on the characteristics of the hydrogel depot, the composite can also be applied on the skin or subcutaneous injection like other hydrogel [56]. ...
... Wound healing is an important and complicated process for maintaining corneal homeostasis and transparency, involving in various cell types, such as corneal epithelial cells, stem cells, neurons and immune cells [56,57]. Although we have demonstrated the different roles of NLRP3 inflammasome in physiological and diabetic corneal wound healing, there are still several limitations in need of resolution. ...
... Meanwhile, existing evidence further suggests that ECM remodeling is down-regulated when autophagy is elevated in patients with pulmonary fibrosis and treated with effective drugs [15]. Likewise, a prior study revealed that conjunctival fibrosis augmented by ECM production could be reversed by autophagy [16]. In a word, Nampt might participate in SUI by modulating ECM degradation and autophagy. ...
... É composto de densos tecidos conjuntivos, fibras elásticas ricas e um grande número de glândulas meibomianas. Estudo desenvolvido por Chen et al. (39) teve como objetivo avaliar o desenvolvimento de células similares aos meibócitos semeadas em uma estrutura de PCL para desenvolvimento por meio da engenharia de tecidos de uma placa tarsal. Citocompatibilidade, adesão celular, proliferação e adipogênese foram verificados in vitro usando sebócitos humanos e in vivo em camundongos com resultados promissores. ...