Neil F. Lobo's research while affiliated with University of Notre Dame and other places

Publications (16)

Preprint
Full-text available
Background: Artemisinin-based combination therapy (ACT) is the most effective treatment for malaria, and has significantly reduced morbimortality. Polymorphisms associated with the Plasmodium falciparum kelch gene (Pfkelch13) propeller domains have been associated with delayed parasite clearance even with ACT treatment. Methods: The Pfkelch13gene w...
Article
Full-text available
Vector-borne diseases are among the most burdensome infectious diseases worldwide with high burden to health systems in developing regions in the tropics. For many of these diseases, vector control to reduce human biting rates or arthropod populations remains the primary strategy for prevention. New vector control interventions intended to be marke...
Article
Full-text available
The effectiveness of artemisinin-based combination therapies (ACTs) depends not only on that of artemisinin but also on that of partner molecules. This study aims to evaluate the prevalence of mutations in the Pfdhfr, Pfdhps, and Pfmdr1 genes from isolates collected during a clinical study. Plasmodium genomic DNA samples extracted from symptomatic...
Article
Full-text available
As gene drive mosquito projects advance from contained laboratory testing to semi-field testing and small-scale field trials, there is a need to assess monitoring requirements to: i) assist with the effective introduction of the gene drive system at field sites, and ii) detect unintended spread of gene drive mosquitoes beyond trial sites, or resist...
Preprint
Full-text available
Background East Nusa Tenggara province, Indonesia, contributed to 5% of malaria cases nationally in 2020, with other mosquito-borne diseases such as dengue and filariasis also being endemic. Monitoring of spatial and temporal vector species compositions and bionomic traits is an efficient method for generating evidence towards intervention strategy...
Chapter
Great challenges to sustained malaria and arbovirus control remain, including transmission by vectors that occur outdoors or outside of sleeping hours, the enormous scale of larval breeding in urban centres and the failure of people to comply with vector control. Furthermore, developing insecticide resistance, shifts in vector dominance and behavio...
Data
Supplementary resources of Small et al. 2020 "Radiation with reticulation marks the origin of a major malaria vector".
Article
Full-text available
Significance Introgressive hybridization is prevalent in recent and rapid animal radiations, and emerging evidence suggests that it leads to the sharing of genetic variation that can facilitate adaptation to new environments and generate novel phenotypes. Here we study a recent and rapid radiation of African mosquitoes in which only one species, An...
Article
Full-text available
According to the WHO, unmanaged insecticide resistance may lead to increases in malaria-related mortality and morbidity. Bangladesh, having made significant progress in malaria control efforts, has recently seen an upswing in malaria cases-58% of which occurred in Bandarban district. Toward identifying entomological drivers of increased malaria, an...
Preprint
Full-text available
Background The Zika AIRS Project, a USAID-funded initiative worked across the Latin America and Caribbean regions from 2016 to 2019, as an emergency to contain the spread of the Zika virus. All entomological records in the target countries showed wide distribution and high abundance of Aedes aegypti populations , however the susceptibility profiles...
Article
50 years after a noble but flawed attempt to eradicate malaria in the mid-20th century, the global malaria community is once again seriously considering eradication. Momentum towards eradication has been building for decades, and more than half of the world’s countries are now malaria free. Since 2000, a surge of global progress has occurred, facil...
Article
Full-text available
Background: Analysis of anti-malarial antibody responses has the potential to improve characterization of the variation in exposure to infection in low transmission settings, where conventional measures, such as entomological estimates and parasitaemia point prevalence become less sensitive and expensive to measure. This study evaluates the use of...
Article
Full-text available
Abstract Background: Globally, the Democratic Republic of Congo (DRC) accounted for 9% of malaria cases and 10% of malaria deaths in 2015. As part of control efforts, more than 40 million long-lasting insecticidal nets (LLINs) were distributed between 2008 and 2013, resulting in 70% of households owning one or more LLINs in 2014. To optimize vector...

Citations

... The most notable example of gene flow between closely related species is in hominins, where 1%-3% of admixed proportion of DNA sequence in Eurasian populations results from introgression from Neanderthals (Sankararaman et al. 2014(Sankararaman et al. , 2016Vernot and Akey 2014). Studies of a range of species including Heliconius butterflies (Nadeau et al. 2013;Zhang et al. 2016;Edelman et al. 2019), African cichlids (Meier et al. 2017;Malinsky et al. 2018;Svardal et al. 2020), Solanum (Pease et al. 2016), Darwin's finches (Lamichhaney et al. 2015(Lamichhaney et al. , 2018Han et al. 2017), and Anopheles (Fontaine et al. 2015;Thawornwattana et al. 2018;Small et al. 2020) all show evidence of substantial introgression. This may be more likely during recent divergence, but in dire wolves (Perri et al. 2021), introgression has occurred during early divergence and is absent between more recent, isolated species. ...
... However, case numbers increased from 2018 to 2019 with a continued high malaria burden in the CHT districts where transmission is historically high [1]. Persistent transmission may be attributed to multiple factors including intervention coverage and usage, as well as the prevalence of high Anopheles diversity [4,9,10] and insecticide resistance [11] in these regions. ...
... Angola belongs to the group of eight nations in southern Africa aiming to eliminate malaria by 2030, as part of the Malaria Elimination Eight Regional Initiative, E8 [19]. In addition to the Government of Angola, the study and control of malaria in the country is supported principally by the United States Agency for International Development (through its U.S. President's Malaria Initiative, USAID/PMI), among other international partners, with the goal of strengthening the country's strategic cooperation and partnership with E8, to consolidate the continent's elimination goal in the West-Southern African countries [16,20,21]. Recent efforts have focused on the characterization of cross-border malaria transmission between Angola and Namibia [22][23][24]. ...
... Overall results show that humoral antibodies against P. falciparum antigens were higher than P. vivax antigens. This finding is consistent with previous studies in low transmission settings in Tak Province in Northwestern Thailand (Baum et al., 2016) and other areas in Southeast Asia, namely, Indonesia (Surendra et al., 2019), Myanmar (Edwards et al., 2021), and Vietnam (San et al., 2022). (100) 133 (100) 75 (100) 137 (100) The practice of managing the illness, n (%) The dominance in exposure to P. falciparum could be attributed to the timing of data collection, which mainly occurred after the transmission season. ...
... Vector control interventions are threatened by the emergence of insecticide resistance. In DRC, the primary vector, Anopheles gambiae sensu lato (s.l.) is generally susceptible to bendiocarb (carbamate) and pirimiphos-methyl (organophosphate), but resistant to DDT (organochlorine), permethrin, deltamethrin, and alphacypermethrin (pyrethroids) [3][4][5][6][7]. The impact of this resistance is undetermined, but in West Africa, resistance to pyrethroids resulted in a decrease in the efficacy of pyrethroid impregnated nets [8][9][10]. ...