Nazliniwaty Nazliniwaty’s research while affiliated with University of North Sumatra and other places

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Publications (9)


Pelayanan Informasi dan Konseling oleh Apoteker tentang Penyakit Degeneratif serta Pemeriksaan Kesehatan kepada Masyarakat di Desa Ndokum Siroga
  • Article
  • Full-text available

July 2022

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41 Reads

PengabdianMu Jurnal Ilmiah Pengabdian kepada Masyarakat

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Aminah Dalimunthe

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Nazliniwaty Nazliniwaty

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Lisda Rimayani Nasution

Degenerative disease is a disease experienced by many people, such as hypertension, coronary heart disease, diabetes mellitus, gout, and others. Pharmacists play a role in providing information and education about health, primarily pharmacological and non-pharmacological drugs. The purpose of the activity is to increase public understanding regarding degenerative diseases from the side of treatment by pharmacists by adopting a healthy lifestyle and understanding the importance of health checks as the first step to early detection of degenerative diseases. The implementation method is in the form of health checks in the form of blood pressure, cholesterol, uric acid, and blood sugar levels so that it can be early detection of degenerative diseases. Information and counseling services by pharmacists regarding healthy lifestyles and information related to treatment and degenerative diseases using brochures and individual direct delivery. The activity was carried out in Ndokum Siroga Village, Karo Regency. The service results were carried out at the village hall with 35 participants. The activity was full of enthusiasm, and many questions arose during the service by the pharmacist. It is known that participants' understanding of degenerative diseases is very low, with only 24% who know about degenerative diseases, 32% who know the symptoms of the disease, 27% who know the risks, and 30% who apply preventive and promotive efforts. 14% of participants do not know that they have the degenerative disease, so it can be concluded that this activity is very helpful and provides good benefits to the community.

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Figure 1: Wound healing migration assay. NIH-3T3 cells were treated by combination of EEALL and EEACL (37.5 μg/mL−37.5 μg/mL) for 0; 24 and 48 h and measured the closure area. (a) Control cells; (b) combination of EEALL and EEACL (37.5 μg/mL−37.5 μg/mL)
Figure 2: Percentage of viable cells of NIH-3T3 cells were treated by a combination of EEALL and EEACL (37.5 μg/mL−37.5 μg/mL) for 24 h, 48, and 72 h and measured viable cells
Figure 3: Representative figures showing VEGFR-2 expression after treatment with combination of EEALL and EEACL (37.5 μg/mL−37.5 μg/mL) (a) bands of VEGFR-2 expressions (A: Control Cell; B: combination of EEALL and EEACL (37.5 μg/mL−37.5 μg/mL), and (b) chart of VEGFR-2 expressions
The Activity of Combination of Ethanol Extract of Artocarpus lacucha Buch.-Ham and Anredera cordifolia Steenis Leaves to Increase Wound Healing Process on NIH-3T3 Cell Line

April 2022

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79 Reads

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5 Citations

Open Access Macedonian Journal of Medical Sciences

Nazliniwaty Nazliniwaty

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Olivia Avriyanti Hanafiah

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[...]

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AIM: This study aims to determine the effect of the combination of ethanol extract of Artocarpus lacucha Buch.-Ham and Anredera cordifolia Steenis leaves to increase cell proliferation and increase VEGFR-2 expression of NIH-3T3. METHODS: The samples used were Artocarpus lacucha Buch.-Ham and Anredera cordifilia Steenis leaves. The powder of simples was extracted using ethanol 80% with maceration method. The effect of extract combination on proliferation was evaluated using the MTT method. Wound healing assay was established by a cell migration method, and VEGFR-2 expression was determined using RT-PCR. RESULTS: The effect of combination of ethanol extract of Artocarpus lacucha leaves (EEALL) and ethanol extract of Anredera cordifolia leaves (EEACL) on cell proliferation after 24h, 48h and 72h incubation found as viable cells were showed (124.33 ± 0.32%; 128.52 ± 0.41%; 118.35 ± 0.22%). Percent of wound closed after 24 h and 48 h incubation are 64.88 ± 0.90% and 100.00 ± 0.00%, and expression of VEGFR-2 increased from 1 (control) to 1.58 ± 0.02. CONCLUSION: The results suggest that a combination of EEALL and EEACL (37.5 μg/mL−37.5 μg/mL) is effective in increasing cells proliferation and hence wound healing process.


Component Analysis of White Ginger (Zingiber officinale Roscoe) Extract and Red Ginger (Zingiber officinale Rubra) Extract

October 2021

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20 Reads

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5 Citations

Tropical Journal of Natural Product Research

Ginger is believed to be a multifunctional medicinal plant that can be used for the treatment of various diseases. Ginger contains large quantities of essential oils, hence, it is possible to use it for pharmacological purposes. Ginger has two varieties, white ginger and red ginger. Essential oils are widely used in aromatherapy as a complementary therapy. The aim of this research was to analyze the differences of chemical content in extracts of white ginger and red ginger. Samples of white ginger and red ginger were extracted by using a Soxhlet extractor with n-hexane as a solvent. Extracts were further analyzed by gas chromatography mass spectrometry. Samples of white ginger and red ginger were obtained at yields of 1.26% and 1.32% respectively. Content of linalool, borneol, zingiberene, and zingerone were significant difference which are higher in red ginger than in white ginger.


PEMANFAATAN EKSTRAK KULIT BUAH DELIMA (Punica granatum L.) DALAM FORMULASI SEDIAAN LIP BALM

May 2020

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256 Reads

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1 Citation

Jurnal Jamu Indonesia

Lip balm merupakan pelembab yang berfungsi untuk melembabkan bibir agar tidak mudah kering dan pecah-pecah. Kulit delima kaya akan flavonoid, asam fenolat, dan tanin yang berkhasiat sebagai antioksidan. Tujuan penelitian ini adalah untuk memformulasi sediaan pelembab bibir menggunakan ekstrak kulit buah delima dan menentukan waktu yang dibutuhkan untuk memberikan efek melembabkan. Kulit buah delima dimaserasi menggunakan pelarut etanol 96% dan dipekatkan dengan rotary evaporator. Ekstrak kulit buah delima dengan konsentrasi 2,5; 5; 7,5; dan 10%, diformulasikan dalam dasar lip balm. Pengujian terhadap sediaan lip balm meliputi uji homogenitas, pengukuran pH, uji iritasi dan uji stabilitas sediaan dengan parameter seperti bau, warna dan pH selama penyimpanan 12 minggu. Pengujian kemampuan sediaan untuk melembabkan menggunakan alat pemeriksa kelembaban dalam perangkat skin analyzer selama perawatan 4 minggu. Hasil penelitian diperoleh bahwa semua sediaan lip balm homogen, memiliki pH 5,6-6,1 stabil selama penyimpanan 12 minggu, dan tidak mengiritasi. Sediaan lip balm ekstrak kulit buah delima dengan konsentrasi 10% dapat memberikan efek melembabkan bibir paling baik yang mampu memulihkan kulit bibir setelah 4 minggu pemakaian. Hasil penelitian disimpulkan bahwa ekstrak kulit buah delima dapat diformulasi dalam bentuk sediaan lip balm dan dengan konsentrasi ekstrak 10% mampu memberikan efek melembabkan bibir setelah 4 minggu pemakaian.


Antiaging Activity of Gel Preparation Containing Three Varieties of Passion Fruit Peel Ethanolic Extract

March 2020

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94 Reads

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9 Citations

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Antiaging cosmetics are cosmetics that can prevent or correct the signs of premature aging. Passion fruit (Passiflora sp.) peel is an agricultural waste contains polyphenol compounds and flavonoids which are a source of natural antioxidants to prevent premature aging. The passion fruit peel extract formulated into gel preparations which can increase the economic value of the passion fruit peel waste. OBJECTIVE: The objective of the study was to test the antiaging activity of gel preparations containing ethanolic extracts of purple, red, and yellow passion fruit on experimental animal skins with several parameters (wrinkle, melanin, pore, moisture, and elasticity). METHODS: Gel was made by adding passion fruit peel extract with several concentrations (0.05%, 0.10%, 0.15%, 0.20%, and 0.25%) in gel base. The blank used is a gel base without extracts. Measurement of wrinkle, black pigment (melanin), pore size, moisture content, and elasticity was performed using a skin analyzer. The use of gel is done 2 times a day for 28 days. RESULTS: Gel with purple, red, and yellow passion fruit peel extract can be formulated into gel preparations. The higher concentration of passion fruit peel extract shows a higher antiaging activity. Gel preparations with purple, red, and yellow passion fruit peel extract, respectively, show the recovery of wrinkle 16.16%, 8.73%, and 6.49%; recovery of melanin 20.11%, 10.75%, and 8.06%; recovery of pore 18.78%, 10.15%, and 7.69%; recovery of moisture 32.74%, 17.70%, and 13.04%; and recovery of elasticity 30.08%, 16.13%, and 12.30%. CONCLUSIONS: The highest antiaging activity was given by gel preparations containing purple passion fruit peel extract and the lowest antiaging activity was given by gel preparations with yellow passion fruit peel extracts.



The characterization results of Plectranthus amboinicus (Lour.) Spreng leaves dried powder
pH evaluation result during storage
The inhibition zone diameter of EEPL mouthwash dosage form
Formulation and Antibacterial Activity of Plectranthus amboinicus (Lour.) Spreng Leaves Ethanolic Extract as Herbal Mouthwash Against Halitosis Caused Bacteria

November 2019

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620 Reads

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17 Citations

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Halitosis is one of the unpleasant conditions which could alter the self-confidence and cause serious illness. One of the treatments to overcome halitosis is by using mouthwash. Plectranthus amboinicus (Lour.) Spreng is one of the plants that is known to have antibacterial activity which can be used to overcome halitosis caused bacteria. AIM: To formulate the Plectranthus amboinicus (Lour.) Spreng leaves ethanolic extract as herbal mouthwash and to evaluate the antibacterial activity against Streptococcus mutans and Staphylococcus aureus bacteria. METHODS: The methods of the study included the characterization and screening of Plectranthus amboinicus (Lour.) Spreng leaves dried powder; the extraction process by maceration using 96% ethanol; the antibacterial activity test of Plectranthus amboinicus (Lour.) Spreng leaves ethanolic extract and the formulation and evaluation of mouthwash dosage form with various concentrations of Plectranthus amboinicus (Lour.) Spreng leaves ethanolic extract. RESULTS: The characterization results showed that the Plectranthus amboinicus (Lour.) Spreng leaves powder contained 7.92% of water, 29.26% of water-soluble substance, 13.32% of ethanol soluble substance, 0.82% of total ash and 0.66% of acid insoluble ash. The screening examination gave glycoside, saponin, flavonoid, tannin and steroid/triterpenoid positive results. The antibacterial activity test of the Plectranthus amboinicus (Lour.) Spreng mouthwash showed that the dosage form with 2% of Plectranthus amboinicus (Lour.) Spreng extract successfully inhibited the growth of bacteria with 12.00 and 11.25 mm of inhibition diameter for both Staphylococcus aureus and Streptococcus mutans, respectively. CONCLUSION: The Plectranthus amboinicus (Lour.) Spreng leaves ethanolic extract can be formulated in mouthwash dosage form and has antibacterial activity against Staphylococcus aureus and Streptococcus mutans bacteria.


Fig. 1: Linearity of potassium standard solution and calcium standard solution 
In vitro antinephrolithiasis effect of breadfruit (Artocarpus altilis (park) fosberg) leaves extract by atomic absorption spectrophotometry

April 2018

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359 Reads

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2 Citations

Asian Journal of Pharmaceutical and Clinical Research

Objective: The objective of this study is to observe the solubility calcium oxalate as a prototype of kidney stone in breadfruit leaf extract solution (n-hexane extract solution, ethyl acetate extract solution, and ethanol extract solution) by atomic absorption spectrophotometry.Methods: Research was conducted qualitatively to analyze calcium oxalate solubility in breadfruit leaf extract solution. The solubility of calcium was known by measuring the levels of calcium in extract solution before and after incubation with calcium oxalate. Potassium as a factor that can enhance the solubility of calcium oxalate also measured by atomic absorption spectrophotometry.Results: The higher concentration of extract solution used in incubation with calciumoxalate, the higher dissolving activity of calcium oxalate. The highest activity was found in ethyl acetate extract to dissolve calcium oxalate. Potassium has a small effect on the activity of dissolving calcium oxalate. Activity may be due to the phytochemical content present in the ethyl acetate extract.Conclusion: Ethyl acetate extract solution has the highest activity to dissolve calcium compared to n-hexane extract and ethanol extract solution.


The utilization of Binahong (Anredera Cordifolia (ten.) steenis) leaf as an anti-aging

April 2018

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253 Reads

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8 Citations

Asian Journal of Pharmaceutical and Clinical Research

Objective: To formulate binahong leaf extract in the microemulsion dosage form and to evaluate the anti-aging effect on the human skin.Methods: Binahong leaf extract was prepared by maceration then formulated into microemulsion dosage form with various concentrations of 0.1%, 0.3%, and 0.5%. The microemulsion preparation was prepared by adding the oil phase to the water phasehen mixed until a clear and transparent microemulsion was formed. Characterization of the dried powder included the determination of water content, water-soluble content, ethanol-soluble content, total ash content, and unsaturated acid ash content. Evaluation of microemulsion preparation included a stability test, determination of homogeneity, density, viscosity, pH, centrifugation, microemulsion type, surface tension, particle size, irritation test, and anti-aging effect test using skin analyzer. Anti-aging parameters measured included moisture, number of spots and wrinkles number.Results: Characterization results showed the water content of 7.48%, water-soluble content of 19.2%, ethanol soluble content of 9.46%, total ash content of 4.65%, and acid content of 0.58%. Microemulsion preparation of the binahong leaf extract was homogen, had low viscosity, pH 6.0–7.0, density of 1.049–1.0753 g/ml, surface tension of 35.24–38.00 dyne/cm, particle size of 364.68–632.72 nm, stable for 12 weeks storage and did not irritate the skin. The results of anti-aging effect measurements showed that the 0.5% binahong leaf extract microemulsion gave the best results.Conclusion: The dried powder of binahong leaf is qualified to be formulated. Microemulsion preparation of 0.5% binahong leaf extract showed the best anti-aging effect.

Citations (8)


... Research has shown that red ginger extract can effectively downregulate the expression of cyclin D1, while upregulating the expression of the cyclindependent kinase inhibitors p21 and p27, which serve to inhibit CDK activity and subsequently impede the transition from the G1 phase to the S phase of the cell cycle. [31,32]. This regulatory mechanism is crucial as CDKS play significant roles in cell cycle progression, and their inhibition can directly halt cell division. ...

Reference:

Potensi Sitotoksik Ekstrak Rizoma Jahe Merah (Zingiber officinale var. rubrum) terhadap Sel Kanker Payudara 4T1
Component Analysis of White Ginger (Zingiber officinale Roscoe) Extract and Red Ginger (Zingiber officinale Rubra) Extract
  • Citing Article
  • October 2021

Tropical Journal of Natural Product Research

... According to research, this plant has various pharmacological effects that are useful as antimalarial, antiviral (for HSV and HIV), antituberculosis, antiatherosclerotic, antifungal, antiplasmodial, antidiabetic, wound healing, and anticancer due to the presence of active ingredients including artocarpin, oxyresveratrol, phenol, and flavonoids (Saowakon et al. 2009;Jagtap and Bapat 2010;Singhatong et al. 2010;Phoolcharoen et al. 2013;Teanpaisan et al. 2014;Nazliniwaty et al. 2021;Hanafiah et al. 2022;Sitorus et al. 2022). The heartwood has been used as a traditional anthelmintic medicine (Gautam and Patel 2014;Nazliniwaty et al. 2022). ...

The Activity of Combination of Ethanol Extract of Artocarpus lacucha Buch.-Ham and Anredera cordifolia Steenis Leaves to Increase Wound Healing Process on NIH-3T3 Cell Line

Open Access Macedonian Journal of Medical Sciences

... Verification parameters [18][19][20][21] During the method validation process, the following parameters (verification parameters) were assessed to ensure the validity of the method: ...

QUANTIFICATION OF ISOORIENTIN IN THREE VARIETIES OF PASSION FRUIT PEEL ETHANOLIC EXTRACT BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY MASS SPECTROMETRY

RASAYAN Journal of Chemistry

... Flavonoid, di sisi lain, telah teridentifikasi sebagai senyawa dengan aktivitas antioksidan yang kuat, yang berfungsi melindungi kulit dari kerusakan akibat radikal bebas dan peradangan. Mereka menghambat aktivitas matrix metalloproteinase-1 (MMP-1), yang merupakan enzim yang menguraikan kolagen dalam kulit yang terpapar sinar matahari [44]. Penghambatan MMP-1 berkontribusi pada stabilitas kolagen, sehingga mendukung kelembapan dan elastisitas kulit [44,45]. ...

Antiaging Activity of Gel Preparation Containing Three Varieties of Passion Fruit Peel Ethanolic Extract

Open Access Macedonian Journal of Medical Sciences

... Oleh karena itu, bibir bisa menjadi kering dan pecah-pecah bila terpapar dengan udara panas ataupun dingin yang berlebihan. Selain tidak enak dipandang, bibir yang pecah-pecah juga menimbulkan rasa nyeri dan tidak nyaman.Sehingga perlu adanya pencegahan serta perawatan pada bibir yaitu dengan penggunaan lip balm [3]. Penggunaan lip balm berbeda dengan lipstick dan lip gloss. ...

PEMANFAATAN EKSTRAK KULIT BUAH DELIMA (Punica granatum L.) DALAM FORMULASI SEDIAAN LIP BALM
  • Citing Article
  • May 2020

Jurnal Jamu Indonesia

... In their work, Nazliniwaty and Lia Laila found that the ethanolic extract from P. amboinicus leaves had antibacterial properties against Streptococcus mutans and Staphylococcus aureus germs and may be made into a mouthwash dosage form. [25] Prior studies have examined the antimicrobial properties of certain herbal items against S. aureus, S. mutans and C. albicans, either separately or in combination. Some of them are readily available and reasonably priced, while others are both costly and commercially uncommon. ...

Formulation and Antibacterial Activity of Plectranthus amboinicus (Lour.) Spreng Leaves Ethanolic Extract as Herbal Mouthwash Against Halitosis Caused Bacteria

Open Access Macedonian Journal of Medical Sciences

... Daun binahong dapat dijadikan bahan anti-aging karena memiliki kandungan metabolit sekunder seperti saponin, flavonoid, quinon, steroid, dan monoterpenoid. Maka dari itu, daun binahong terkenal dengan kemampuannya dalam memberikan dampak baik salah satunya penyakit kulit dan anti-aging (Nazliniwaty et al., 2018). Berdasarkan hasil uji statistik (Tabel 2), kelompok C-dengan masing-masing T1 dan T2 berbeda signifikan (P<0,05). ...

The utilization of Binahong (Anredera Cordifolia (ten.) steenis) leaf as an anti-aging
  • Citing Article
  • April 2018

Asian Journal of Pharmaceutical and Clinical Research

... From the calibration curve measurements (Figure 1), the regression Y=0.101443X+0.000795 was obtained. The calcium correlation cofficient obtained could be accepted according to Harmita (2004) and Putra et al (2018) [10], [11], [12]. ...

In vitro antinephrolithiasis effect of breadfruit (Artocarpus altilis (park) fosberg) leaves extract by atomic absorption spectrophotometry

Asian Journal of Pharmaceutical and Clinical Research