Naushaad Ebrahim's research while affiliated with University of the Western Cape and other places

... Translating these modified EVs into clinics, as discussed above, has major challenges, and more research is needed as they have a long way to go to achieve their full therapeutic potential. The synthetic DDSs, such as NPs [136][137][138], liposomes [139][140][141][142], dendrimers [143][144][145], micelles [146][147][148], nanocapsules [149][150][151], nanosponges [152,153], peptide-based nanoparticles [154], etc., have good drug encapsulation efficiency (EE), drug loading (DL) capacity, flexibility in functionalization, easy/robust production, and theragnostic functions. However, conjugation of a PEG polymer, peptide, antibody, etc. may develop drug tolerance [54,127] and even cause allergy [48]. ...

... NLB-SLN brain targeting was confirmed by noninvasive scintigraphy, reaching its maximum permeability eighth h after intranasal administration. Omarch et al. [145] conducted a comparative study; the authors developed polymeric PCL NPs and phosphatidylcholine LP to evaluate pentamidine in vitro transport through the BBB. The pentamidine-loaded PCL NPs had a mean size of 267.58 nm, PDI of 0.25, and zeta potential of -28.1 mV, while pentamidine-loaded LP had a mean size of 119.61 nm, PDI of 0.25, and zeta potential 11.78 mV. ...

... Nanotechnology, defined as the science of designing, producing, and the application of materials at a nanometre scale, is one of the most exciting and fast-moving areas of science that may revolutionize many aspects of life [1]. This discipline has galvanized researchers worldwide and has contributed to the development of novel products for applications in the health, energy, food, agriculture, and water sectors [2]. In order to harness the benefits of nanotechnology, the SA government has, over the past 16 years, made extensive investments toward creating a critical mass of infrastructure, equipment, and human capital for nanotechnology research [1][2][3]. ...

... As such, a module topic would be covered asynchronously or non-systematically in the different disciplines over the four-year study period, thereby fragmenting student learning. In addition to the on campus theoretical and laboratory-based teaching, the school's experiential learning programme, Service Learning in Pharmacy (SLiP), aims to provide real world experiences for students to apply their theoretical knowledge [24]. An externship experience, also allows students to clock hours in pharmacies during their vacation periods. ...