Naushaad Ebrahim's research while affiliated with University of the Western Cape and other places

Publications (5)

Article
Introduction The study aimed to develop and explore the efficiency of a surface-modified 4.0 G PAMAM dendrimer as a novel delivery system for the anti-tuberculosis (TB) drug, rifampicin. Methods The 4.0 G PAMAM dendrimer having various concentrations of polyethylene glycol (PEG) 2 kDa content was synthesized using 4-nitrophenyl chloroformate as an...
Article
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The conventional approach in the tablet formulation of acetaminophen (ACM) suggests the use of five or more different excipients in a wet granulation tableting process. The use of many excipients in tablet formulation may negatively create excipient-excipient interactions, excipient-drug interactions, exaggerated product side effects, and high drug...
Article
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Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis (HAT) in polymer based nanoparticles and liposomes and compared their capability to enhance pent-amidine penetration across blood brain barrier (BBB). Siz...
Article
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Nanomedicine is one of the most exciting applications of nanotechnology and promises to address several of mankind’s healthcare needs. South Africa is one of the countries engaged in nanomedicine research and product development on the African continent. In this article, we provide a top-level description of the policy, infrastructure, and human ca...
Article
High patient load and understaffing in public health care facilities preclude the provision of optimal pharmaceutical services in South Africa. A Service Learning in Pharmacy (SLIP) programme for the University of the Western Cape's final year pharmacy students was implemented in health care facilities to assist in service provision. Students rotat...

Citations

... Translating these modified EVs into clinics, as discussed above, has major challenges, and more research is needed as they have a long way to go to achieve their full therapeutic potential. The synthetic DDSs, such as NPs [136][137][138], liposomes [139][140][141][142], dendrimers [143][144][145], micelles [146][147][148], nanocapsules [149][150][151], nanosponges [152,153], peptide-based nanoparticles [154], etc., have good drug encapsulation efficiency (EE), drug loading (DL) capacity, flexibility in functionalization, easy/robust production, and theragnostic functions. However, conjugation of a PEG polymer, peptide, antibody, etc. may develop drug tolerance [54,127] and even cause allergy [48]. ...
... NLB-SLN brain targeting was confirmed by noninvasive scintigraphy, reaching its maximum permeability eighth h after intranasal administration. Omarch et al. [145] conducted a comparative study; the authors developed polymeric PCL NPs and phosphatidylcholine LP to evaluate pentamidine in vitro transport through the BBB. The pentamidine-loaded PCL NPs had a mean size of 267.58 nm, PDI of 0.25, and zeta potential of -28.1 mV, while pentamidine-loaded LP had a mean size of 119.61 nm, PDI of 0.25, and zeta potential 11.78 mV. ...
... Nanotechnology, defined as the science of designing, producing, and the application of materials at a nanometre scale, is one of the most exciting and fast-moving areas of science that may revolutionize many aspects of life [1]. This discipline has galvanized researchers worldwide and has contributed to the development of novel products for applications in the health, energy, food, agriculture, and water sectors [2]. In order to harness the benefits of nanotechnology, the SA government has, over the past 16 years, made extensive investments toward creating a critical mass of infrastructure, equipment, and human capital for nanotechnology research [1][2][3]. ...
... As such, a module topic would be covered asynchronously or non-systematically in the different disciplines over the four-year study period, thereby fragmenting student learning. In addition to the on campus theoretical and laboratory-based teaching, the school's experiential learning programme, Service Learning in Pharmacy (SLiP), aims to provide real world experiences for students to apply their theoretical knowledge [24]. An externship experience, also allows students to clock hours in pharmacies during their vacation periods. ...