Nathalie Farpour-Lambert's research while affiliated with University of Geneva and other places

Publications (52)

Chapter
The continued high prevalence of childhood and adolescent obesity emphasizes the need for both clinical and community‐based approaches to prevention and treatment. This chapter highlights evidence‐based and emerging treatment for child obesity, based on a new understanding of obesity as a biological condition rather than a personal lifestyle decisi...
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Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other...
Conference Paper
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Effective interventions for the prevention and treatment of child and adolescent obesity play an important role in reducing the global health and economic burden of non-communicable diseases. Although multi-component interventions targeting various health behaviors are deemed promising, evidence for their effectiveness is still limited. Self-regula...
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Background: Less than 2% of overweight children and adolescents in Switzerland can participate in multi-component behaviour changing interventions (BCI), due to costs and lack of time. Stress often hinders positive health outcomes in youth with obesity. Digital health interventions, with fewer on-site visits, promise health care access in remote re...
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The World Health Organization declared COVID-19, the infectious disease caused by the coronavirus SARS-CoV-2, a pandemic on March 12, 2020. COVID-19 is causing massive health problems and economic suffering around the world. The European Association for the Study of Obesity (EASO) promptly recognised the impact that the outbreak could have on peopl...
Chapter
Physical activity is an important determinant of physical and mental health during adolescence. However, the pubertal period is marked by substantial physical, psychological and social changes, and is considered as a critical window in competitive sports. Adolescent athletes have increased risks of musculoskeletal injuries, as well as psychological...
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This paper was originally published under a standard licence. This has now been amended to a CC BY licence in the PDF and HTML.
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The first contact for patients with obesity for any medical treatment or other issues is generally with General Practitioners (GPs). Therefore, given the complexity of the disease, continuing GPs’ education on obesity management is essential. This article aims to provide obesity management guidelines specifically tailored to GPs, favouring a practi...
Article
Children and adolescents with overweight and obesity are a global health concern. This is an integrative overview of six Cochrane systematic reviews, providing an up-to-date synthesis of the evidence examining interventions for the treatment of children and adolescents with overweight or obesity. The data extraction and quality assessments for each...
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Bariatric patients may face specific clinical problems after surgery, and multidisciplinary long-term follow-up is usually provided in specialized centers. However, physicians, obstetricians, dieticians, nurses, clinical pharmacists, midwives, and physical therapists not specifically trained in bariatric medicine may encounter post-bariatric patien...
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Objective: Partly inconsistent findings from previous reviews have fueled discussions on the impact of sugar-sweetened beverages (SSBs) on obesity development. The aim was to systematically review the recent evidence in children and adults. Methods: Data were retrieved from the databases MEDLINE, EMBASE, and Cochrane library for the period Janua...
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Bariatric surgery is today the most effective long-term therapy for the management of patients with severe obesity, and its use is recommended by the relevant guidelines of the management of obesity in adults. Bariatric surgery is in general safe and effective, but it can cause new clinical problems and is associated with specific diagnostic, preve...
Conference Paper
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Health professionals have limited resources and are not able to personally monitor and support patients in their everyday life. Against this background and due to the increasing number of self-service channels and digital health interventions, we investigate how text-based healthcare chatbots (THCB) can be designed to effectively support patients a...
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One of the main aims of the European Childhood Obesity Group (ECOG) is to assist healthcare workers in delivering evidence-based assessment and treatment of childhood obesity. Every year the ECOG Congress includes working groups whose objective is to highlight concerns faced by clinicians and practitioners who work in the field of pediatric obesity...
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Obesity is a serious health issue and predisposes individuals to an increased risk of morbidity and mortality. Its prevalence in children has increased worldwide. To demonstrate the feasibility and effectiveness of a school-based management program based on healthy lifestyle promotion for obese and overweight adolescents in Sousse, Tunisia. We cond...
Article
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Water is an essential nutrient for all physiological functions and particularly impor-tant for thermoregulation. About 60% of our body weight is made of water. Under standard conditions (18–20 ° C and moderate activity), water balance is regulated within 0.2 % of body weight over a 24-hour period. Water requirement varies between individuals and ac...
Article
Forearm fractures are common in the pediatric population and are mostly treated by cast immobilization. The purposes of this study were first to determine whether forearm fractures in adolescents are associated with abnormal bone mineral density (BMD) or content (BMC) at the time of fracture, and second, to quantify the bone mineral loss at various...
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Background: In adolescents, loss of bone mineral mass usually occurs during phases of reduced physical activity (PA), such as when an injured extremity spends several weeks in a cast. We recorded the PA of adolescents with lower limb fractures during the cast immobilization, at 6 and at 18 months after the fracture, and we compared these values wi...
Article
Leg or ankle fractures occur commonly in the pediatric population and are primarily treated with closed reduction and cast immobilization. The most predictable consequences of immobilization and subsequent weight-bearing restriction are loss of bone mineral mass, substantial muscle atrophy, and functional limitations. The purposes of this study wer...
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Immobilization and associated periods of inactivity can cause osteopenia, the physiological response of the bone to disuse. Mechanical loading plays an essential role in maintaining bone integrity. Skeletal fractures represent one cause of reduction of the physical activity (PA) level in adolescents. The purpose of this study was to quantify the re...
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Early detection of subclinical manifestations of obesity is important to initiate early effective treatment aiming at reversing the process. Recent studies using echocardiography tissue doppler or strain rate imaging have suggested the potential of motion tracking methods to characterize subtle systolic changes that may be associated with obesity i...
Article
Population strategies to increase physical activity are an essential part of cardiovascular disease prevention. However, little data exist on lifestyle interventions that are easy to integrate into everyday life such as using stairs instead of elevators at the workplace. Pre and postintervention study. A 12-week promotional campaign for stair use c...
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When expressed as a percentage of the average result in young adults, bone mineral content lags behind bone length before puberty. Even though this observation has led to speculation about bone fragility in children, such relationships could simply be due to scaling effects when measures with different geometrical dimensions are compared. The study...
Article
Few studies have explored osteogenic potential of prepubertal populations. We conducted a 28-week school-based exercise trial of single-leg drop-landing exercise with 42 prepubertal girls (6 to 10 years) randomly assigned to control (C), low-drop (LD) or high-drop (HD) exercise groups. The latter two groups performed single-leg drop-landings (3 ses...
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We carried out a cross-section study of the sex-specific relationship between bone mineral content and physical activity at sites with different loading in pre- and early pubertal girls and boys. There was significant sensitivity of bone mineral content of the hip to physical exercise in boys, but not in girls. Since little is known whether there a...
Article
The prevalence of childhood obesity increases dramatically. First signs of cardiovascular diseases and type 2 diabetes appear early in life. The treatment of childhood obesity aims at weight maintenance during growth, normalization of body mass index at long-term and prevention of complications. The family based behavioural therapy is a promising a...
Article
The incidence of childhood obesity is dramatically increasing worldwide. In Switzerland, 20% of youth are overweight and 5 to 8% are obese. First signs of cardiovascular diseases and type 2 diabetes may appear early in life. The obesity epidemic is mainly due to major changes in our society resulting in sedentary lifestyle and energy-dense food int...
Article
This study compared tibial bone and muscle geometry and total body and regional bone mineral content (BMC) in elite female adolescent middle-distance runners (n = 20, age: 16 ± 1.7 years) and age- and sex-matched controls (n = 20, 16 ± 1.8 years) using magnetic resonance imaging and dual-energy X-ray absorptiometry. Significant advantages were foun...
Article
The impact of high training volumes on musculoskeletal adaptations of male adolescents is poorly understood. We compared bone mineral content (BMC) of total body, lumbar spine and proximal femur using Dual X-ray Absorptiometry (Lunar Prodigy, GE Medical Systems, Madison WI) in elite level (n=20), male adolescent middle distance runners (mean 16.8 y...
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In upper extremity bones, a sexual dimorphism exists in the development of periosteal and endocortical bone surfaces during growth. Little is known about developmental patterns of bone geometry at weight-bearing bones like the femur. Using MRI and dual energy X-ray absorptiometry (DXA), this study assessed the differences in mid-femoral total (TA),...
Article
The correlates and determinants of total body (TB), femoral neck (FN), greater trochanter (GT) and leg areal bone mineral density (aBMD), and FN volumetric (vol) BMD were investigated in 42 healthy 6-10-year-old girls. Predictor variables included age, height, weight, lean tissue mass (LTM), fat mass, percent body fat, physical activity level, calc...
Article
More than ever, many young athletes are being encouraged to train intensely for sporting competitions from an early age. Compared with studies in adults, less is known about the physiological trainability of adolescents. The velocity of physical growth during the adolescent years makes research with a group of young athletes particularly difficult....

Citations

... Usually, NAFL is a silent disease, and most people are asymptomatic and their daily lives are not affected. A certain number of individuals with NAFL can develop NASH, which can lead to liver inflammation, and may further progress to the advanced scarring (cirrhosis) and cause liver failure [4,5]. Thus, it is critical to monitor NASH progressions and take effective preventions. ...
... Second, another limitation of our study concerns its limitation to German-speaking people ranging in age from 18 to 65 years only. Digital interventions addressing younger or older clients beyond this age range (eg, older people suffering from dementia [76] or younger clients with child obesity [116]) are likely to require different designs, content, and functionalities of the chatbot (research direction 3). For instance, the interpersonal relationship of an older client with cancer with a peer chatbot is likely to be of another kind than the relationship of a pregnant woman with a "pregnant" peer chatbot. ...
... Psychological interventions, incorporated alongside traditional behavioural obesity treatment strategies, or as stand-alone interventions, target psychological factors that might contribute to eating behaviours and obesity, including distorted body image, negative mood, and stimulus control. 125,147 A core objective of psychological interventions is to reduce barriers for behaviour change. 147 Cognitive behavioural therapy (CBT) is the most frequently used approach, and addresses the relationship between cognitions, feelings, and behaviours using behavioural therapy techniques to modify behaviours and cognitive techniques to modify dysfunctional cognitions. ...
... The European Association for the Study of Obesity (EASO) has recognized the impact of the COVID-19 epidemic on people living with obesity. Emerging data suggest that obesity is a risk factor for the more serious and complex course of COVID-19 in adults [10]. Therefore, people living with obesity should be prioritized for COVID-19 vaccination [11]. ...
... PI weight loss is partly or completely reversed after treatment [53]. PIs are only recommended as add-on to LIs [54]. See [54] for a more detailed overview on LI, [55] for BS, and [52] for PI. ...
... There is a correlation between the frequency of visits and weight outcome [8]. The US Preventive Services Task Force estimated that families with children suffering from obesity need at least 26 h of contact with the behavioral support team per year to enable children to reach a clinically relevant reduction in the degree of obesity [9]. ...
... Studies show that sufficient PA leads to an improvement in cardiorespiratory endurance capacity and muscle function, a better quality of life, a positive effect on mental health and less premature mortality [2][3][4]. At least 150 min per week of moderate intensity PA for post-bariatric patients is recommended by the Obesity Management Task Force of the European Association for the Study of Obesity to achieve and maintain successful weight loss and reduce the risk of weight regain [5]. Independent of sufficient PA, high levels of sedentary behavior (SB) are recognized as an independent risk factor for developing chronic diseases [6], with more time spent sedentary associated with negative cardio-metabolic health effects in the general population [7]. ...
... A negative association was found between the "healthy" dietary scores and patterns and most obesity markers, whereas a positive association was found with the "unhealthy" dietary scores and patterns. Those findings are in agreement with current literature that emphasizes the beneficial effects of a healthy diet in obesity prevention (4,(34)(35)(36). ...
... Sugar-sweetened beverages (SSBs) include sugary soft drinks (or regular sodas), fruit drinks, sports/energy drinks, and all other beverages with added sugar [1]. Sugary soft drinks are the most consumed type of SSBs [1,2], with high intake contributing to childhood obesity [3,4] and dental caries [5]. Adolescents and young adults are the largest consumers of SSBs worldwide [1,[6][7][8][9]. ...
... Bariatric surgery is effective in the management of extreme obesity and associated comorbidities, including CMS risk [55], with well-established long-term benefits on weight loss, diabetes, hypertension and dyslipidaemia [56]. While the effect of this intervention has already been reported [57,58], little is known about the underlying molecular mechanisms. ...