Natasha Hough's research while affiliated with Oxford University Hospitals NHS Trust and other places
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Publications (6)
Background
Mycobacterium abscessus has emerged as a significant clinical concern following reports that it is readily transmissible in health-care settings between patients with cystic fibrosis. We linked routinely collected whole-genome sequencing and health-care usage data with the aim of investigating the extent to which such transmission explai...
In our recent study of 203 sequential isolates evaluating the ability of whole genome sequencing (WGS) to predict clarithromycin resistance in Mycobacterium abscessus ( M. abscessus ) (1), we demonstrated high sensitivity but poor specificity of mutations identified in a literature search. …
Mycobacterium abscessus is emerging as an important pathogen in chronic lung diseases, with concern regarding patient-to-patient transmission. The recent introduction of routine whole-genome sequencing (WGS) as a replacement for existing reference techniques in England provides an opportunity to characterize the genetic determinants of resistance....
Mycobacterium abscessus is emerging as an important pathogen in chronic lung diseases with concern regarding patient to patient transmission. The recent introduction of routine whole genome sequencing (WGS) as a replacement for existing reference techniques in England provides an opportunity to characterise the genetic determinants of resistance. W...
Citations
... However, growing genotyping evidence indicates that the worldwide MDR-TB epidemic is mainly driven by direct transmission of MDR M. tuberculosis strains [5]. Besides, under-recognized and undertreated MDR-TB patients maintain drug-resistant strains in the community for prolonged periods through uninterrupted chains of transmission, thus increasing the risk of spontaneous emergence of additional drugresistance conferring mutations [6]. ...
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... Sequence quality and GC content of obtained sequence data were assessed using fastQC (Babraham Bioinformatics, Cambridge, United Kingdom). The prediction of macrolide and aminoglycoside resistance was performed using the mab-ariba database by Lipworth et al., with the addition of rrs gene mutations to detect aminoglycoside resistance (28). ...
... However, growing genotyping evidence indicates that the worldwide MDR-TB epidemic is mainly driven by direct transmission of MDR M. tuberculosis strains [5]. Besides, under-recognized and under-treated MDR-TB patients maintain drug-resistant strains in the community for prolonged periods through uninterrupted chains of transmission, thus increasing the risk of spontaneous emergence of additional drug-resistance conferring mutations [6]. ...
