Nátaly Domingues Almeida’s research while affiliated with São Paulo State University and other places

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Publications (5)


Physicochemical properties of common bioinks for neural tissue engineering.
Advances in 3D Bioprinting for Neuroregeneration: A Literature Review of Methods, Bioinks, and Applications
  • Article
  • Full-text available

August 2024

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1 Citation

Micro

Abrar Islam

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Nátaly Almeida

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Rodrigo França

Recent advancements in 3D-bioprinting technology have sparked a growing interest in its application for brain repair, encompassing tissue regeneration, drug delivery, and disease modeling. This literature review examines studies conducted over the past five years to assess the current state of research in this field. Common bioprinting methods and key parameters influencing their selection are explored, alongside an analysis of the diverse types of bioink utilized and their associated parameters. The extrusion-based 3D-bioprinting method emerged as the most widely studied and popular topic, followed by inkjet-based and laser-based bioprinting and stereolithography. Regarding bioinks, fibrin-based and collagen-based bioinks are predominantly utilized. Furthermore, this review elucidates how 3D bioprinting holds promise for neural tissue repair, regeneration, and drug screening, detailing the steps involved and various approaches employed. Neurovascular 3D printing and bioscaffold 3D printing stand out as the top two preferred methods for brain repair. The recent studies’ shortcomings and potential solutions to address them are also examined and discussed. Overall, by synthesizing recent findings, this review provides valuable insights into the potential of 3D bioprinting for advancing brain repairment strategies.

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Carbon fiber felt scaffold from Brazilian textile PAN fiber for regeneration of critical size bone defects in rats: A histomorphometric and microCT study

Journal of Biomedical Materials Research Part B Applied Biomaterials

Kauê Alberto Pereira

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Letícia Cavassini Torquato

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Clarissa Carvalho Martins Maciel

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The objective of the present study was to evaluate the carbon fiber obtained from textile PAN fiber, in its different forms, as a potential scaffolds synthetic bone. Thirty‐four adult rats were used (Rattus norvegicus, albinus variation), two critical sized bone defects were made that were 5 mm in diameter. Twenty‐four animals were randomly divided into four groups: control (C)—bone defect + blood clot, non‐activated carbon fiber felt (NACFF)—bone defect + NACFF, activated carbon fiber felt (ACFF)—bone defect + ACFF, and silver activated carbon fiber felt (Ag‐ACFF)—bone defect + Ag‐ACFF, and was observed by 15 and 60 days for histomorphometric, three‐dimensional computerized microtomography (microCT) and mineral apposition analysis. On histomorphometric and microCT analyses, NACFF were associated with higher proportion of neoformed bone and maintenance of bone structure. On fluorochrome bone label, there was no differences between the groups. NACFF has shown to be a promising synthetic material as a scaffold for bone regeneration.


Applications of 3D bioprinting in periodontal disease.
Regenerating alveolar bone with bioink.
Cont.
Regenerating the periodontal ligament with bioink.
3D Bioprinting Techniques and Bioinks for Periodontal Tissues Regeneration—A Literature Review

August 2024

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4 Citations

Biomimetics

The periodontal tissue is made up of supporting tissues and among its functions, it promotes viscoelastic properties, proprioceptive sensors, and dental anchorage. Its progressive destruction by disease leads to the loss of bone and periodontal ligaments. For this reason, biomaterials are constantly being developed to restore tissue function. Various techniques are being used to promote regenerative dentistry, including 3D bioprinting with bioink formulations. This paper aims to review the different types of bioink formulations and 3D bioprinting techniques used in periodontal tissue regeneration. Different techniques have been formulated, and the addition of different materials into bioinks has been conducted, with the intention of improving the process and creating a bioink that supports cell viability, proliferation, differentiation, and stability for periodontal tissue regeneration.


Biomaterials and their properties and application in tendon bioprinting.
Exploring the Frontier of 3D Bioprinting for Tendon Regeneration: A Review

August 2024

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1 Citation

Eng—Advances in Engineering

The technology of 3D bioprinting has sparked interest in improving tendon repair and regeneration, promoting quality of life. To perform this procedure, surgical intervention is often necessary to restore functional capacity. In this way, 3D bioprinting offers a scaffold design, producing tendons with precise microarchitectures, promoting the growth of new tissues. Furthermore, it may incorporate bioactive compounds that can further stimulate repair. This review elucidates how 3D bioprinting holds promise for tendon repair and regeneration, detailing the steps involved and the various approaches employed. They demonstrate future challenges and perspectives and provide valuable information on the concept, bioprinting design, and 3D bioprinting techniques for the repair of tendon injuries.


Tratamento periodontal e reabilitador em paciente com fibroma ossificante periférico em área estética: relato de caso, com acompanhamento de cinco anos

May 2024

Brazilian Journal of Periodontology

INTRODUÇÃO: O fibroma ossificante periférico (FOP) é uma lesão não neoplásica de crescimento lento, que se origina a partir de células do ligamento periodontal ou do periósteo, sua etiologia ainda é desconhecida. OBJETIVO: Este relato de caso tem como objetivo demonstrar o tratamento periodontal, bem como a reabilitação com implante, e o acompanhamento de uma paciente diagnosticada com FOP na região anterior de maxila. RELATO DE CASO: Paciente do sexo feminino, 53 anos de idade, procurou atendimento devido à presença de lesão, mobilidade e extrusão do dente #21. Além disso, a paciente foi diagnosticada com periodontite estágio III generalizada grau B, passou por terapia periodontal e optou por realizar exodontia do dente #21, em conjunto com a biópsia excisional da lesão apresentada. Durante a biópsia, além da lesão de tecido mole, foram removidos periósteo e exostose óssea subjacentes à lesão. O laudo confirmou diagnóstico de processo proliferativo não neoplásico na forma de FOP. Após dois anos de acompanhamento de recidiva ou não da lesão, a paciente passou por tratamento reabilitador com implante. CONCLUSÃO: O presente relato demonstra um caso clínico de sucesso, no qual uma paciente diagnosticada com um processo proliferativo não neoplásico conseguiu seguir para tratamento reabilitador sem recidivas, ao ter a lesão e fatores irritativos locais devidamente removidos. A paciente continua a ter sua condição bucal acompanhada anualmente e não apresenta qualquer sinal de recidiva da lesão. PALAVRAS-CHAVE: Fibroma ossificante. Periodontite. Implantação dentária. Biópsia.

Citations (3)


... Combining these approaches could be the bridge to the next era of medical activity, especially in this category of patients [133]. Future directions include refining bioprinting technologies, enhancing the mechanical aspects of fully bioprinted constructs, and also optimizing the design to better support angiogenesis and nerve regeneration, but also to address the costs that these techniques include [133,167,168]. The roadmap to achieving these goals, in our view, is by making hybrid parts that combine the mechanical stability of simple 3D-printed parts with the biological activity of other softer materials such as polymers used also in classical 3D printing and the biological activity of 3D-bioprinted scaffolds. ...

Reference:

3D Bioprinting in Limb Salvage Surgery
Advances in 3D Bioprinting for Neuroregeneration: A Literature Review of Methods, Bioinks, and Applications

Micro

... Laser-based bioprinting, such as laser-induced forward transfer (LIFT), offers unparalleled resolution and cell viability, crucial for replicating the brain's complex microstructures, but it can be slow, expensive, and limited in scalability. Stereolithography, while capable of producing highly detailed structures with good resolution, often faces biocompatibility issues with its photopolymerizable materials and may struggle with incorporating living cells directly into the printing process [75][76][77]. Each of these techniques presents a trade-off between resolution, scalability, cell viability, and material versatility, with ongoing research aimed at overcoming their respective limitations to better replicate the intricate architecture and functionality of brain tissue. ...

Exploring the Frontier of 3D Bioprinting for Tendon Regeneration: A Review

Eng—Advances in Engineering

... Similarly, boned barrier membranes do not consistently achieve true periodontal regeneration involving new cementum and functional PDL fibers. 7,8 Given these challenges, periodontal regeneration aims not only to repair but also to fully restore the architecture and functionality of these tissues These objectives cannot be achieved by traditional therapies. Recent advancements in tissue engineering such as PDLSC delivery via biomaterial scaffolds offer a promising solution to these limitations. ...

3D Bioprinting Techniques and Bioinks for Periodontal Tissues Regeneration—A Literature Review

Biomimetics