Nataliya M Kushnir-Sukhov's research while affiliated with National Institute of Allergy and Infectious Diseases and other places

... However, the heterogeneity of mast cells lies also in their ontogeny, and likely arises from their origins during early development or adulthood as well as the stimuli they receive, potentially in ways that are not yet fully characterized. Some mast cells, although not their precursors, are radioresistant and long-lived, possibly surviving for years in certain tissues 23 . In addition, they have dynamic responses to infections and inflammatory stimuli, being capable of local proliferation in some circumstances as well as survival and regranulation following activation, which contrasts with the propensity of many immune cells to undergo apoptosis after activation. ...

... Two studies indicated no statistical difference in the infiltration of mast cells between irradiated and non-irradiated groups [8,19]. These studies suggest that mast cells are resistant to radiation exposure in the urinary bladder, consistent with reports on mast cells exhibiting resistance to radiationinduced cytotoxicity [31,32]. Contrastingly, two studies indicated a decrease [20,23] and one study indicated an increase in mast cell density following irradiation [22]. ...

... Interestingly, MSCs, including WJ-MSCs, may interact with and modulate the activation and function of all key immune effector cells including T or B cells (Le Blanc et al., 2004;Aggarwal and Pittenger, 2005;Uccelli et al., 2006;Carreras-Planella et al., 2019), monocyte or macrophages (Cutler et al., 2010;Dymowska et al., 2021;Lu et al., 2021), dendritic cells (DCs) (Tipnis et al., 2010;Gao et al., 2017;Vieira Paladino et al., 2019), neutrophils (Khan et al., 2015;Ahn et al., 2020;Taghavi-Farahabadi et al., 2021), mast cells (Brown et al., 2011;Cho et al., 2022), and natural killer cells (Casado et al., 2013;Najar et al., 2018;Abbasi et al., 2022). Although the mechanism of immunomodulatory activity remains to be elucidated, it is thought that both cell-to-cell contact and soluble factors are the key players in WJ-MSCs mediated immunosuppression (Shi et al., 2010;Ma et al., 2014). ...

... The mast cell produces and secretes heparin and various enzymes that affect blood clotting and blood vessels. Interestingly for us, this cell also contains serotonin (Kushnir-Sukhov et al., 2008). E represents another form of so-called paracrine signaling. ...

... www.nature.com/scientificreports/ are typically present in ISM, osteosclerosis is more frequently identified in AdvSM 26,27 . We recently showed that an increased BMD is strongly associated with advanced disease and inferior outcome 19 . ...

... IL-6 and IL-8 later promote AS by upregulating the expression of adhesion molecules on ECs and recruiting leukocytes [106]. Second, NMs can stimulate mast cell activation and the release of TGF-α, chymotrypsin and trypsin-like enzymes by activating scavenger receptors such as SR-A, SR-B1 and Marco [107,108]. TGF-α upregulates the expression of adhesion molecules on ECs, and the main effect of chymotrypsin and trypsinlike enzymes is matrix degradation, these two lead to plaque instability [106]. Third, NMs can activate the complement system by inducing complement C5a and C3a to bind to C5a and C3a receptors on mast cells [109], stimulating histamine release from mast cells, which enhances vascular permeability and causes vascular leakage, leading to an increased risk of intraplaque hemorrhage [110]. ...

... [62] In addition, 5-HTR2B and 5-HTR7 are involved in the maintenance of the anti-inflammatory state of macrophages. Mast cells can produce 5-HT by expressing TpH1, [63] and the expression level of TpH1 is higher than that of other immune cells. [64] Kushnir-Sukhov et al. [62] also found that mast cells express multiple 5-HTRs, including 5-HTR1A, 5-HTR1B, 5-HTR1E, 5-HTR2A, and 5-HTR2B and identified 5-HTR1A as the main receptor mediating the effect of 5-HT on mast cells. ...

... The expression of M1-related genes such as INHBA, CCR2, MMP12, SERPINE1, CD1B and ALDH1A2 was decreased. [62] In addition, 5-HTR2B and 5-HTR7 are involved in the maintenance of the anti-inflammatory state of macrophages. Mast cells can produce 5-HT by expressing TpH1, [63] and the expression level of TpH1 is higher than that of other immune cells. ...

... Recently, novel variants of MC disorder have been introduced the so-called "monoclonal mast cell activation syndrome" (MMAS). 35,36 These patients also present with severe episodes of anaphylaxis, often with hypotensive syncope and have detectable clonal MCs expressing the D816V mutation and/or CD251 aberrant markers. However, they do not fulfill the WHO criteria for SM diagnosis and lack typical skin changes (see Table 1). ...