Natalie Garcia Bartels's research while affiliated with Charité Universitätsmedizin Berlin and other places

Publications (77)

Article
Importance: Uncombable hair syndrome (UHS) is a rare hair shaft anomaly that manifests during infancy and is characterized by dry, frizzy, and wiry hair that cannot be combed flat. Only about 100 known cases have been reported so far. Objective: To elucidate the genetic spectrum of UHS. Design, setting, and participants: This cohort study incl...
Article
Full-text available
Background: Dry skin and the associated impaired epidermal barrier function are postulated to constitute a major element in the development of atopic dermatitis. Objective: The aim of this study was to evaluate the effect of two plant-based formulations on the epidermal barrier function in a defined cohort of infants with a predisposition for atopi...
Article
Alopecia areata (AA) is one of the most common forms of human hair loss. Although genetic studies have implicated autoimmune processes in AA etiology, understanding of the etiopathogenesis is incomplete. Recent research has implicated microRNAs, a class of small noncoding RNAs, in diverse autoimmune diseases. To our knowledge, no study has investig...
Article
Full-text available
Objectives The aim of this study was to measure the prevalence of skin diseases in aged nursing home residents and to explore possible associations with demographic and medical characteristics. Design Descriptive multicentre prevalence study. Setting and participants The study was conducted in a random sample of ten institutional long-term care f...
Article
Background: Aged residents of institutional long-term care facilities are at high risk for developing skin and tissue diseases. Besides various common skin problems, dry skin (xerosis cutis) is one of the most frequent skin conditions in this setting. Objectives: To investigate the effectiveness of two structured skin care regimens in comparison...
Article
Background: Skin care influences skin barrier function during the first postnatal weeks. Although the use of natural oils in preterms has been investigated, there are currently no data comparing the effect of sunflower oil to an emollient on barrier development in healthy term newborns. Methods: In a prospective, randomized clinical study, 50 he...
Article
Uncombable hair syndrome (UHS), also known as "spun glass hair syndrome," "pili trianguli et canaliculi," or "cheveux incoiffables" is a rare anomaly of the hair shaft that occurs in children and improves with age. UHS is characterized by dry, frizzy, spangly, and often fair hair that is resistant to being combed flat. Until now, both simplex and f...
Article
Full-text available
Table of contents WORKSHOP 4: Challenging clinical scenarios (CS01–CS06) CS01 Bullous lesions in two children: solitary mastocytoma S. Tolga Yavuz, Ozan Koc, Ali Gungor, Faysal Gok CS02 Multi-System Allergy (MSA) of cystic fibrosis: our institutional experience Jessica Hawley, Christopher O’Brien, Matthew Thomas, Malcolm Brodlie, Louise Michaelis C...
Article
Background: Dry skin is a common skin condition in childhood. Few studies exist investigating the influence of daily skin care on dry skin in infants at risk of developing atopic dermatitis (AD). We aimed to assess the effect of skin care on dry skin in this special cohort using validated scores for AD and analysis of skin microtopography. Method...
Article
Alopecia areata (AA) is a common hair loss disorder of autoimmune etiology, which often results in pronounced psychological distress. Understanding of the pathophysiology of AA is increasing, due in part to recent genetic findings implicating common variants at several genetic loci. To date, no study has investigated the contribution of copy number...
Article
Introduction: In women receiving antineoplastic therapy, hair loss is often accompanied by distressing hair or scalp sensations, such as hair pain (trichodynia) and pruritus. A scientific approach to objectively evaluate the course and characteristics of these unpleasant sensations is of great importance for the establishment of treatment strategi...
Article
Haarausfall im Kindesalter stellt in der Regel für den behandelnden Kinderarzt und Dermatologen eine diagnostische und therapeutische Herausforderung dar. Daher ist es sinnvoll, zunächst anhand des klinischen Musters eine Klassifizierung vorzunehmen, um dann mittels trichologischer Diagnostik weitere Differenzialdiagnosen abzugrenzen [1].
Article
5% minoxidil formulations twice daily are effective in treating vertex male androgenetic alopecia (AGA); however, efficacy and safety data in frontotemporal regions are lacking. To assess the efficacy of 5% minoxidil topical foam (5% MTF) in the frontotemporal region of male AGA patients after 24 weeks of treatment compared to placebo treatment and...
Article
The effect of different diaper care procedures on skin barrier function in infants has been minimally investigated and may be assessed using objective methods. In a single‐center, prospective trial, 89 healthy 9‐month‐old infants (±8 wks) were randomly assigned to three diaper care regimens: group I used water‐moistened washcloths at diaper changes...
Article
Abbreviations: AA, alopecia areata; FASLG, Fas ligand (TNF superfamily, member 6); GWA, genome-wide association; HLA-DQA2, MHC class II DQ alpha 2; HLA-DQB, MHC class II DQ beta; KIAA0350/CLEC16A, C-type lectin domain family 16, member A; MHC, major histocompatibility complex; OX40L, OX40 ligand; THADA, thyroid adenoma associated; TNF, tumor necros...
Article
Background: Inadequate skin care may increase morbidity in preterm infants. Skin care practices that support skin maturation have barely been investigated. Objectives: To investigate the effect of sunflower seed oil (SSO) on skin barrier development in low-birth-weight premature infants. Methods: 22 preterm infants (<48 h after birth, 1,500-2,...
Article
BACKGROUND: In preterm infants, skin barrier maturation entails regional variability. OBJECTIVES: To characterize postnatal skin barrier development in covered, uncovered and diapered regions in healthy premature infants over a longitudinal observation period. METHODS: Transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH and sebum...
Article
Diaper dermatitis (DD) is one of the most common skin conditions in neonates and infants, with a peak between the ages of 9 and 12 months. Appropriate skin care practices that support skin barrier function and protect the buttocks skin from urine and feces are supposed to be effective in the prevention of DD. Despite many recommendations for parent...
Article
Background: Dry skin reflects a skin barrier defect which can lead to atopic dermatitis. Little is known about the distinct effects of emollient use in children with dry skin and atopic predisposition. Objectives: We investigated the effects of daily application of pressed ice plant juice (PIPJ)-based emollients and petrolatum-based emollients....
Article
Full-text available
The skin of neonates and infants exhibits distinct anatomical and functional properties that might be clinically reflected by its characteristic susceptibility to skin barrier disruption. In this systematic review, we aimed to characterize skin barrier maturation as reflected by transepidermal water loss (TEWL) and skin surface pH during the first...
Article
Background In women with breast cancer, chemotherapy-induced alopecia is a highly feared but common side-effect of antineoplastic treatment. The onset, pattern and amount of hair loss differ depending on the therapy regimen and have not yet been quantified using standardized techniques. Objectives To evaluate objectively and compare the effect of a...
Article
AnamneseEin 12-jähriges Mädchen nicht konsanguiner deutscher Eltern stellte sich mit seit 3 Jahren langsam progredienten Hyperkeratosen im Bereich der Fingermittelgelenke an beiden Händen in unserer kinderdermatologischen Hochschulambulanz vor. Durch Basistherapie mit pflegenden Externa zeigte sich eine leichte Besserung des Befundes. Eigenanamnese...
Article
The aetiopathogenesis of female pattern hair loss (FPHL) is poorly understood. Although research has strongly implicated genetic factors in familial occurrence, no association finding for FPHL has yet been replicated. Consequently, no causal biological pathways can be suggested on the basis of currently available genetic findings. A recent gene-wid...
Conference Paper
Hintergrund und Ziele: Die postnatale Unreife der Hautbarrierefunktion bei Frühgeborenen stellt die Etablierung von Pflegekonzepten vor eine große Herausforderung. Bisher gibt es kaum Studien, welche die postnatale Maturation der Barrierefunktion bei Frühgeborenen unter Berücksichtigung anatomischer Variabilität und einheitlicher Hautpflege quantit...
Conference Paper
Ziel: Aufgrund der postnatalen Unreife der Hautbarriere bei Frühgeborenen können verschiedene Pflegemaßnahmen die perinatale Morbidität beeinflussen. Die Anwendung von Sonnenblumenöl (SO) zur Hautpflege von Frühgeborenen ist weit verbreitet, wobei Studien fehlen, welche den Einfluss auf die Barrierefunktion von Frühgeborenen standardisiert untersuc...
Article
Ziel: Sauglinge mit atopischer Pradisposition weisen haufig eine trockene Haut auf, welche mit einer gestorten Hautbarrierefunktion assoziiert ist. Aktuelle Erkenntnisse lassen vermuten, dass eine tagliche Hautpflege bereits ab dem Sauglingsalter die Manifestationsrate einer atopischen Dermatitis senken konnte. Um die Barrierefunktion in diesem Kol...
Article
Background: Biophysical skin measurement techniques are widely used to quantify the skin barrier function. In clinical research usually several parameters are subsequently measured in the same skin areas. In this study, possible interfering effects of subsequent measurement procedures on transepidermal water loss (TEWL), stratum corneum hydration...
Article
A 7-year-old girl presented with complaints of hair loss and a known partial biotinidase deficiency since birth. Biotin supplementation was discontinued after the first year of life because clinical manifestations were absent, and laboratory findings were normal. At age 2 years, hair loss and eczema occurred. Owing to low biotinidase activity, biot...
Article
Non-contact methods for quantifying skin surface topography in vivo are common in skin research. The surface evaluation of living skin (SELS) and the phaseshift rapid in vivo measurement of skin (PRIMOS) are two approaches to measure skin surface roughness and wrinkling via optical methods. The aim of this study was to compare the reliability and i...
Article
Noninvasive diagnostic tools, such as Trichoscan®, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT), are efficient methods of hair shaft and growth evaluation. The aim of this study was to carry out a comparative assessment of these three medical procedures by measuring the hair shaft and hair growth after hair removal...
Article
Background Antineoplastic treatment for breast cancer is frequently associated with alopecia. Increasingly, changes in the texture and shape of regrowing hair after chemotherapy have been reported, without evaluation on a scientific basis. Optical coherence tomography (OCT) provides highly reproducible measurements of hair shaft parameters. Objecti...
Article
Full-text available
Recently, the first genome-wide association study (GWAS) of alopecia areata (AA) was conducted in a North-American sample, and this identified eight susceptibility loci surpassing genome-wide significance. The aim of the present follow-up association analysis was to confirm five of these eight loci (single-nucleotide polymorphisms (SNPs) from the C...
Article
Full-text available
Alopecia areata (AA) is a common hair loss disorder, which is thought to be a tissue-specific autoimmune disease. Previous research has identified a few AA susceptibility genes, most of which are implicated in autoimmunity. To identify new genetic variants and further elucidate the genetic basis of AA, we performed a genome-wide association study u...
Article
Adaptation of skin barrier function and interleukin-1α (IL-1α) content in diapered and nondiapered skin are poorly characterized in newborns receiving standard skin care. In a monocentric, prospective pilot study 44 healthy, full-term neonates were randomly assigned to skin care with baby wipes (n = 21) or water-moistened washcloth (n = 23) at each...
Article
In recent years, there have been continuing efforts to understand the effects of baby skin care routines and products on the healthy development of baby skin. Such efforts aim ultimately to determine the best infant skin care practices. The pediatric and dermatologic communities have not reached consensus on what constitutes an appropriate cleansin...
Article
Variations in hair shaft morphology reflect ethnical diversity, but may also indicate internal diseases, nutritional deficiency, or hair and scalp disorders. The measurement and the follow-up of the hair shaft thickness over a defined period of time would be a valuable diagnostic tool in clinical practice. Standard light microscopy (LM) measurement...
Article
Latanoprost is a prostaglandin analogue used to treat glaucoma. It can cause adverse effects, such as iridial and periocular hyperpigmentation, and eyelash changes including pigmentation and increased thickness, length, and number. Latanoprost has been used to treat eyelash alopecia, but knowledge on its effects on human scalp hair growth is not av...
Article
Although twice-daily application of propylene glycol-containing 2% minoxidil topical solution (MTS) stimulates new hair growth, higher concentrations of minoxidil in a once-daily, propylene glycol-free formulation may improve efficacy and reduce unpleasant side effects. We sought to compare the efficacy, safety, and acceptability and to show noninf...
Article
Skin care is important especially in infancy as the skin barrier matures during the first year of life. We studied the effects of baby swimming and baby lotion on the skin barrier function of infants. 44 infants aged 3-6 months were included in this mono-center prospective study. The healthy infants swam four times and were randomized to group(L) :...
Article
Optical coherence tomography (OCT) is able to provide highly reproducible measurements of hair shaft thickness, including hair shaft diameter, cross-sectional surface area and hair shape, similar to histology but in vivo. Variations in the caliber of hair shafts have been described in patchy hair loss like alopecia areata (AA) using electron micros...
Article
In the past, it was assumed that the intercellular route was the only relevant penetration pathway for topically applied substances. Recent results on follicular penetration emphasize that the hair follicles represent a highly relevant and efficient penetration pathway and reservoir for topically applied substances. This study investigates a select...
Article
Neuere Studien haben gezeigt, dass die Reifung der Hautschutzbarriere mindestens uber die ersten 12 Lebensmonate hinweg anhalt. Vor diesem Hintergrund gewinnt die richtige Hautpflege an Bedeutung, nicht zuletzt unter dem Aspekt der Pravention von Hauterkrankungen, die mit einer fruhen Storung der Hautfunktion assoziiert werden. Deshalb verglichen z...
Article
The effect of topical skin care products on neonatal skin barrier during first 8 weeks of life has not been scientifically evaluated. In a prospective, randomized clinical study, we compared the influence of three skin care regimens to bathing with water on skin barrier function in newborns at four anatomic sites. A total of 64 healthy, full-term n...
Article
La caída del cabello en un niño puede estar relacionada con un gran número de diagnósticos diferenciales que plantean al dermatólogo o al pediatra un verdadero desafío diagnóstico y terapéutico. Una clasificación precisa de la enfermedad de los cabellos, sobre todo en presencia de un síndrome genético subyacente, una deficiencia metabólica o trasto...
Article
After birth, skin barrier function is in state of flux and at risk of dysfunction. In a prospective clinical study, we compared the effects of 2 standard cleansing procedures on skin barrier function in newborns. Fifty-seven healthy full-term neonates aged < or = 48 h were randomly assigned to either a bathing group (group B; n = 29), who were bath...
Article
Haarerkrankungen im Kindes- und Jugend-alter umfassen eine breite Differenzialdiagnose und stellen für den behandelnden Dermatologen und Kinderarzt häufig eine diagnostische und therapeutische Herausforderung dar. Die korrekte Einordnung der Haarerkrankung, insbesondere bei Stoffwechselstörungen und genetischen oder endokrinen Erkrankungen, ist in...
Article
1 +Haberland CPerou M Encephalocraniocutaneous lipomatosis: a new example of ectomesodermal dysgenesis. Arch Neurol 1970;22 (2) 144- 155PubMed Link to Article[[XSLOpenURL/10.1001/archneur.1970.00480200050005]]2 +Happle RKuster W Nevus psiloliparus: a distinct fatty tissue nevus. Dermatology 1998;197 (1) 6- 10PubMed Link to Article[[XSLOpenURL/10.11...
Article
Haarveränderungen im Alter gewinnen infolge der erhöhten Lebenserwartung und der damit neuen Altersverteilung der Bevölkerung zunehmend an Bedeutung. Das Bild des Alterns und dessen Begleiterscheinungen haben einen negativen Charakter in einer Gesellschaft erhalten, in der die psychische Verfassung und die individuelle Leistungsfähigkeit mehr und m...
Article
• Hair loss in children comprises a broad spectrum of disorders. • Hair shaft defects with increased fragility simulate hair loss and should be considered in children with abnormal hair growth. • Hair loss may present as localized, patchy or as diffuse alopecia. • Close inspection of the scalp helps to further differentiate between non-scarring alo...
Article
Hay-Wells syndrome is a rare form of ectodermal dysplasia, also known as AEC syndrome (Ankyloblepharon filiforme adnatum, Ectodermal effects, Cleft lip/palate). It is inherited in an autosomal dominant fashion with variable expression, featuring congenital abnormalities of skin, hair, teeth, nail, eccrine and mucous glands. We present a three-month...
Article
Two drugs which are approved for the treatment of androgenetic alopecia in women in Germany were compared with regard to their influence on hair growth. Patients were randomized to group I (n = 52) who used 2% minoxidil solution twice daily for a period of 12 months or to group II (n = 51) who used 0.025% alfatradiol solution once daily for 6 month...

Citations

... However, a significant reduction in TEWL was found in the group who received the application for 48 h compared with 24 h, indicating a lesser skin barrier alteration 48 h after application. Previous studies have evaluated the effect of plant-based lotion on skin permeability showing how different composition of the lotion and different plant species can modify the TEWL of the skin in physiological and pathological conditions [22,23]. For Salicornia species, only one study has evaluated the skin condition after a long application of S. europaea, showing that treatment with S. europaea extract helps improve the skin texture, and through a skin model authors showed the importance of the orientation in the stem cells in maintaining skin homeostasis [12]. ...
... Als Off-Label-Therapie steht mit Clofazimin ein weiteres Medikament aus der Lepratherapie zur Behandlung zur Verfügung [1,12]. Des Weiteren wird eine erhöhte Produktion von Tumornekrosefaktor (TNF)α für möglich gehalten, was eine erfolgreiche Therapie mit Infliximab in einem Fallbericht mit Assoziation zu Morbus Crohn untermauert [13]. ...
... Genome-wide miRNA analysis [37] identified differential expression of three miRNAs in AA compared to controls: miR-30b/d, miR-1237, and miR-548 h-2. A marked reduction of miR-30b was observed in hair follicles of AA patients compared to healthy controls, and its expression has been observed to vary significantly with the hair cycle, suggesting miR-30b may be important in the pathogenesis of AA [37]. ...
... We have not used immunobiological therapy in MRS, although we feel that their use might be of help and they should be further studied. 25,26 We employed surgical treatment in 3 situations: complete resistance to oral medications, residual lip enlargement after disease control (a common situation, in which lip consistency softens but the lip remains enlarged) (Figure 4a and b & c), and in severe gingival compromise (a presentation that almost never improves with medical treatment only) (Figure 4d & e). 27 In conclusion, it is necessary to pay attention to seldomly described manifestations of MRS. ...
... With the development of nanomedicine, dermatological disease has attracted tremendous attention owing to their advantages of high prevalence and visible symptoms [176,177]. Currently, flexible polymeric patch has also been extensively applied for diverse skin diseases treatment including actinic keratosis, scars, and acne, etc. [178] For instance, Lotti et al. utilized polymeric MN patches to effectively suppress atrophic acne scar without any severe complication and post-inflammatory hyperpigmentation through enhancing skin roughness and pigmentation spots in patients. Xu's group fabricated a self-administered and drug-free MN patch for effectively inhibiting the abnormal scars post-injury [179]. ...
... Захворювання має багатофакторний характер, що передбачає комплексну взаємодію генетичних особливостей організму й екзогенних впливів. ГА має генетичну основу з низьким ступенем пенетрантності в сім'ях [31,32]. Близько 20% осіб із ГА мають позитивний сімейний анамнез. ...
... Thirty-two of the 34 papers are underpinned by an implicit acceptance of the idea that knowledge in nursing should be evidence-based. The way of understanding evidence in these papers is as a measurement of the effectiveness of products or caring regimes, for example, with a randomized design (Achterberg et al., 2016;Beeckman et al., 2011;Clarke-OʼNeill et al., 2015;Gillis et al., 2016;Hahnel et al., 2017;Kon et al., 2017;Liu et al., 2017;Schnelle et al., 2013;Scho