Nasim Wiegley’s research while affiliated with University of California, Davis and other places

... Lupus nephritis is another significant kidney complication, occurring in approximately 60% of patients with systemic lupus erythematosus [5]. Collectively, all forms of kidney diseases are considered life-threatening, with poor diagnosis and ineffective therapies contributing to increased mortality and morbidity each year. ...

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Acyl-CoA Synthetase Long-Chain Isoenzymes in Kidney Diseases: Mechanistic Insights and Therapeutic Implications

... Focal segmental glomerulosclerosis (FSGS) is a significant cause of nephrotic syndrome, particularly in adults [1,2]. It is characterized by segmental scarring of the glomeruli, leading to proteinuria and progressive loss of kidney function [3]. FSGS can arise primarily (idiopathic) or secondarily due to underlying conditions such as obesity, diabetes, infections, or nephrotoxic drugs [4]. ...

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Focal Segmental Glomerulosclerosis With Superimposed Infection‐Related Glomerulonephritis in a Diabetic Patient: A Case of Rapid Renal Decline

... LN is a form of glomerulonephritis with deposition of immune complexes (ICs) and complement, which results in renal tissue damage in the kidneys of LN patients, endothelial damage, and microthrombi formation [17]. Although renal biopsy has long been considered the "gold standard" for diagnosis of LN [18], its invasive nature and limited scope of renal tissue analysis warrant a more advanced approach. The need for non-invasive and sensitive diagnostic and prognostic methods is evident. ...

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Urine Extracellular Vesicles Size Subsets as Lupus Nephritis Biomarkers

... Lupus nephritis (LN) is a glomerulonephritis arising from Systemic Lupus Erythematosus, a chronic autoimmune disease in which women of childbearing age are particularly implicated. In pregnancy, the disease results in increased risk to maternal health, including pre-eclampsia, hypertension, and thromboembolic events, as well as fetal risks, such as preterm birth, congenital heart block, and intrauterine growth restriction (11). Therefore, management of pregnancy in lupus nephritis patients requires careful planning and thorough monitoring for possible complications. ...

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Editorial: Insights in glomerular disease

... [78] In addition, Flohr also gave insights into very promising ongoing clinical investigations of iptacopan for the treatment of kidney diseases such as IgA nephropathy (IgAN), [77c] C3 glomerulopathy (C3G), [77d] and Lupus Nephritis. [79] This further underlines the outstanding and pioneering work of the Novartis team, which made the therapeutic potential of FB inhibitors accessible to patients in various indications. ...

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We are MedChem: The Frontiers in Medicinal Chemistry 2024

... To examine the ability of SCGP to recognize known tissue structures, we assessed its performance on a cohort of 17 tissue sections from 12 individuals with diabetes and various stages of diabetic kidney disease (DKD). 40 Tissue samples were imaged using the mIF platform CODEX 9 and further annotated for four major kidney compartments: glomeruli, blood vessels, distal tubules, and proximal tubules. This cohort will be referred to as the DKD Kidney dataset (STAR Methods) in the subsequent text. ...

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Discovery and generalization of tissue structures from spatial omics data

... These unexpected findings associated with SGLT2i and CV health were discovered after the US Food and Drug Administration (FDA) required evidence of CV safety involving the intake of new hypoglycemic agents [4][5][6][7][8][9]. Additionally, some evidence has also been attributed to them as likely retinal protective agents [10] and may also offer renal protection [11], thus placing them into a category of pleiotropic agents, as some authors say [12,13]. ...

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A Systematic Review and Meta-Analysis of Sodium-Glucose Cotransporter 2 (SGLT-2) Inhibitors and Their Impact on the Management of Heart Failure

... In 2021, Inker et al. developed two equations, namely CKD-EPI creatinine 2021 and CKD-EPI creatinine cystatin C 2021, which omit race and improve the accuracy of kidney function assessment [16]. Goodson et al. [28] evaluated the eGFR in 637 potential living kidney donors, comparing the accuracy of the MDRD formulas and CKD-EPI creatinine 2009 and CKD-EPI creatinine 2021 formulas with the mGFR assessed using iohexol. The results showed that the value calculated using the CKD-EPI creatinine 2021 formula was less biased and more accurate than those derived from previous creatinine-based estimated GFR equations, with a P30 value of 96.4% in Asian individuals. ...

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Accuracy of Estimated Glomerular Filtration Rate Equations in Potential Vietnamese Living Kidney Donors

... infection. The reason for this is unclear, but the urinary flow elevation related to the osmotic diuresis and natriuresis effects of SGLT2i may be a factor [11,27]. On the other hand, although a potential association of SGLT2i with musculoskeletal pain such as myopathy is a concern [14,15], our results did not show such an association. ...

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Association between sodium-glucose cotransporter-2 inhibitor and adverse events in patients with moderate to severe chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials

... In kidney transplant recipients, BK virus causes nephropathy and urologic complications, such as hemorrhagic cystitis or ureteral stenosis. JC virus is known to cause progressive multifocal leukoencephalopathy (PML) in HIV patients, but its involvement in polyomavirus allograft nephropathy (PVAN) is rare [2]. Here we describe two cases of JC-related nephropathy occurring late after kidney transplantation and provide a review of the literature. ...

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JC Polyomavirus Nephropathy: A Rare Complication Late after Kidney Transplantation