Narumi Shiida's research while affiliated with Hokkaido University and other places

Publications (4)

Article
The ω-6 and ω-3 polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are the precursors of various bioactive lipid mediators including prostaglandins, thromboxanes, leukotrienes, hydroxyeicosatetraenoic acid, isoprostanes, lipoxins, and resolvins (Rvs). These lipid mediators...
Article
Previous studies indicated that several members of the multidrug resistance-associated protein (MRP) family mediate the transport of prostanoids.However, theimportance of MRPs in the release process of prostanoids has not been fully elucidated. In this study, we investigated the contribution of MRPs, including MRP1, MRP2, and MRP4, to the release p...
Article
Carboplatin is a platinum agent that is used for treatment of non-small-cell lung cancer and ovarian cancer. A sensitive and selective analytical method for the quantification of carboplatin in human plasma ultrafiltrates using liquid chromatography-tandem mass spectrometry was developed. Human plasma ultrafiltrates were precipitated by acetonitril...

Citations

... In cantharidin-induced human blisters, RvD1 and RvD2 are identified and are increased in female subjects vs. male subjects 18 . Specific SPMs are also identified in human urine, namely RvD1, 17-epi-RvD1, and RvE2, from smokers and non-smokers 44 . ...
... In humans, SPMs which are rapidly metabolized and degraded are found at pico to nanogram levels in blood, breastmilk, the airways (breath condensate and sputum), urine, and tears (Gangemi et al., 2003;Levy et al., 2007;Psychogios et al., 2011;Mas et al., 2012;Weiss et al., 2013;Colas et al., 2014;Ringholz et al., 2014;Sasaki et al., 2015;Barden et al., 2016;Dalli et al., 2017;Eickmeier et al., 2017;English et al., 2017). The short half-life of SPMs, whether they are endogenous or synthetic, led to the manufacturing of the first analogs of LXA4 by Serhan and his collaborators have made it easier to study their biological effects. ...
... Earlier work by Furugen et al. has shown that the ABCC4 inhibitors, MK-571 and probenecid, as well as ABCC4 siRNA treatment, reduce the extracellular levels of PGE2 in A549 lung adenocarcinoma derived cells 21 . ...
... Intact carboplatin was measured in plasma by high performance liquid chromatography with tandem mass spectrometric detection as previously reported with minor modifications [52,53]. Frozen tissue samples were thawed, rinsed three times with ice-cold phosphate buffered saline, gently blotting with filter paper between each rinsing, and weighed in a microcentrifuge tube. ...