Nanjan Mulla Jogge’s research while affiliated with JSS College of Pharmacy and other places

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Publications (1)


Figure 1. Effect of Herbex-kid (HK) on mast cell degranulation induced by C 48/80 in rat mesentery tissue. Values are mean AE SEM. Number of tissues per group is six. *a P50.001 vs control; *b P50.001 vs C 48/80; One way ANOVA followed by Tukey's multiple comparison test. DSSG: disodium cromoglycate; C 48/80: Compound 48/80.
Table 1 . Effect of Herbex-kid in nasal allergy in antigen sensitized rats
Figure 2. Effect of Herbex-kid (HK) in C 48/80 induced systemic anaphylaxis in Balb/C mice. Each bar represents mean AE SEM of six mice each. ** P50.01 vs control. One way ANOVA followed by Dunnett's multiple comparison test. C 48/80: Compound 48/80.
Figure 3. Effect of Herbex-kid (HK) in active (plain bars) and passive anaphylaxis (shaded bars) model in rats. Each bar represents mean Æ SEM of six rats each. * P 5 0.05, ** P 5 0.01 vs the experiment 
Figure 4. Herbex-kid (HK) at various doses in C 48/80 (Compound 48/ 80)-induced itching in Balb/C mice. Each bar represents mean of six mice each. ***a P 5 0.001 vs vehicle control; *b P 5 0.05, ***b P 5 0.001 vs C 
Herbex-Kid Inhibits Immediate Hypersensitivity Reactions in Mice and Rats
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January 2008

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146 Reads

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9 Citations

Evidence-based Complementary and Alternative Medicine

Anil Kumar

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Rawal Prasad

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Nanjan Mulla Jogge

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[...]

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S. Prabakar

Herbex-kid (HK), a polyherbal formulation was evaluated in various experimental allergic models of Type I hypersensitivity reactions. Compound 48/80 (C 48/80) has been shown to induce rat mesentery mast cell degranulation and HK (1.07, 10.75 and 107.5 mg ml(-1)) inhibited the mast cell degranulation in a dose dependent manner. HK (1.07, 10.75 and 107.5 mg kg(-1); p.o.) showed dose-dependent protection against C 48/80 induced systemic anaphylaxis in male Balb/C mice. In active anaphylaxis model, male Wistar rats orally administered with 10.75 and 107.5 mg kg(-1) of HK showed significant (P < 0.01) protection against mast cell degranulation, while in passive anaphylaxis model, only at 107.5 mg kg(-1) showed significant (P < 0.01) reduction in mast cell degranulation. HK at all dose levels was able to significantly decrease the time spent in nasal rubbing in Wistar rats sensitized to ovalbumin, while only at 107.5 mg kg(-1) it showed significant (P < 0.01) reduction in number of sneezes. In C 48/80-induced skin itch model, all dose levels of HK significantly (P < 0.001) decreased the time spent in itching and the number of itches. HK did not produce any significant inhibition in histamine induced contraction in guinea pig ileum. From the above findings we conclude that the HK possesses antiallergic activity mediated by reducing of the release mediators from mast cells and also by 5-HT antagonism without the involvement of histamine (H1) receptors.

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... This is because no treatment-related histopathological International Journal of Scientific Research changes were observed in any of the organs. 16 Mast cell stabilizing activity on rat mesentry Animals The study used female Wistar albino rats, which were bought from Sree Venkateshwara Enterprises Pvt. Ltd. in Bangalore. Five groups of rats were formed (n=5). ...

Reference:

EVALUATION OF MAST CELL STABILIZING EFFECT OF ERAIPPU NOI CHOORANAM (ENC) ON RAT MESENTRY
Herbex-Kid Inhibits Immediate Hypersensitivity Reactions in Mice and Rats

Evidence-based Complementary and Alternative Medicine