Nagao Azuma's research while affiliated with Yamaguchi University and other places

Publications (144)

Article
A new general approach to a variety of unsymmetrical telluronium salts has been developed. Treatment of diaryltellurinyl difluorides 1 with silyl enol ethers 2 in the presence of BF3·OEt2 gave (2-oxoalkyl)diaryltelluronium tetrafluoroborates 3 in quantitative yield. When a siloxycyclopropane, an allylsilane, a benzylstannane, an alkenylstannane, an...
Article
The Raman spectra of alpha form 5-nitro-2,4-dihydro-1,2,4-triazole-3-one (alpha-NTO, space group P) were measured in a high-pressure vessel diamond anvil cell (DAC). The pressure was increased to 27.6 GPa. In general, Raman bands show a blue shift because of the nature of the molecule packing as a high-pressure effect, but some particular bands exh...
Article
Four kinds of 1:1 salts of 3-(4- and 3-alkyl-pyridinium)-1,5- diphenylverdazyl (alkyl = ethyl and methyl) radical cations with the Ni(dmit) 2 anion ([p-EtPyDV] +[Ni(dmit) 2] - (1), [m-EtPyDV] +[Ni(dmit) 2] - (2), [p-MePyDV] +[Ni(dmit) 2] - (3), and [m-MePyDV] +[Ni(dmit) 2] - (4)) have been prepared. The magnetic properties of salts 1-4 were discuss...
Article
Five kinds of (1:1) and (1:3) salts of 3-(4- and 3-alkyl-pyridinium)-1,5-diphenylverdazyl (alkyl=ethyl and methyl) radical cations with Ni(dmit)2 anion ([p-EtPyDV]+[Ni(dmit)2]− (1), [m-EtPyDV]+[Ni(dmit)2]− (2), [p-MePyDV]+[Ni(dmit)2]− (3), [m-MePyDV]+[Ni(dmit)2]− (4), and [p-MePyDV]+[Ni(dmit)2]3-(5)) (dmit=1,3-dithiol-2-thione-4,5-dithiolate) have...
Article
Four kinds of 1:1 and 1:3 salts of 3-[4-(trimethylammonio)phenyl]-1,5-diphenyl-6-oxoverdazyl radical cation ([1](+)) and its mono- and dimethyl derivatives ([2](+) and [3](+)) with Ni(dmit)(2) anions (dmit = 1,3-dithiol-2-thione-4,5-dithiolate) ([1](+)[Ni(dmit)(2)](-) (4), [2](+)[Ni(dmit)(2)](-) (5), [3](+)[Ni(dmit)(2)](-) (6), and [1](+)[Ni(dmit)(...
Article
We observed peripapillary staphyloma in 6 eyes of 6 patients. Their ages ranged from 6 to 18 years. Their visual acuity ranged from 0.04 to 1.5. The axial length was between 23 mm to 25 mm. The depth of the disc excavation was between 2 to 4 mm. Optical coherence tomography (OCT) showed, in all the eyes, the presence of sensory retina with irregula...
Article
Two kinds of iodide salts of 3-(4- and 3-methylpyridinium)-1,5-diphenylverdazyl radical cations ([p-MePyDV]+I− (1) and [m-MePyDV]+I− (2)) and four kinds of 1 ∶ 1 and 1 ∶ 2 salts of the same verdazyl radical cations with tetracyanoquinodimethanide (TCNQ) anion ([p-MePyDV]+[TCNQ]− (3), [m-MePyDV]+[TCNQ]− (4), [p-MePyDV]+[TCNQ]2− (5), and [m-MePyDV]+[...
Article
Five kinds of (1:1), (1:3), and (2:1) salts of 3-[4-(diethylmethylammonio)phenyl]-1,5-diphenyl-6-oxoverdazyl radical cation [V](+) with M(dmit)(2) anions (M = Ni, Zn, Pd, and Pt, dmit = 1,3-dithiol-2-thione-4,5-dithiolate) ([V](+)[Ni(dmit)(2)](-) (1), [V](+)[Ni(dmit)(2)](3)(-) (2), [V](+)(2)[Zn(dmit)(2)](2-) (3), [V](+)(2)[Pd(dmit)(2)](2-) (4), and...
Article
2,2,4,4,6,6-Hexakis(4-pyridylmethoxy)-2λ 5, 4λ 5,6λ 5,-cyclotriphosphazene (PyPN) and 1,4-anthracenedicarboxylic acid (DCA) formed polymeric supramolecules through hydrogen bonding between carboxyl and pyridyl groups. Two supramolecular self-assemblies were obtained: crystals 1 composed of PyPN/DCA = 1:2 from DMSO solution, and crystals 2 composed...
Article
Magnetic susceptibilities (χM) of three kinds of 3-(aryl-substituted)-1,5-diphenyl-verdazyl radical crystals (aryl:  4-fluorophenyl (p-FPDV), 4-pyridyl (p-PyDV), and 3-pyridyl (m-PyDV)) have been measured between 1.8 and 300 K, showing a broad maximum Tmax at 200, 272, and 157 K, respectively. The values of Tmax observed are 1 or 2 orders of magnit...
Article
The appearance and clinical course of rhegmatogenous retinal detachments in children are more complicated than those of adults, because the retinal detachments are generally associated with trauma or congenital anomalies.1, 2 In an infant, especially, an unexpected course may develop; however, the incidence of these detachments is so low that treat...
Article
Three kinds of (1:1) salts of TCNQF 4 anion with 3-(4-trimethylaminophenyl)-1,5-diphenyl-6-oxo-verdazyl radical cation [1 + ] and its mono-methyl [2 + ] and di-methyl [3 + ] derivatives have been prepared, and magnetic property and crystal structure of the salts have been studied. The salts were found to be new genuine organic magnetic compounds co...
Article
Four kinds of (1:1) and (1:2) salts of 3-(4- and 3-ethyl-pyridinium)-1,5-diphenylverdazyl radical cations with tetracyanoquinodimethanide (TCNQ) anion ([p-EtPyDV]+[TCNQ]− (1), [m-EtPyDV]+[TCNQ]− (2), [p-EtPyDV]+[TCNQ]2− (3), and [m-EtPyDV]+[TCNQ]2− (4)) have been prepared, and the magnetic susceptibilities (χM) measured between 1.8 and 300 K. The v...
Article
An idea for a relation between the frequency and intensity of the optimal oscillating magnetic field for the magnetic effects has been presented. An estimated optimal frequency is about 150 Hz for a system containing ions of effective molecular weight of M approximately 100 under a square pulsing magnetic field of intensity H=1 mT.
Article
Sedimentary calcium carbonate was grown at a physiological pH6.8 from a mixture of equivolume of 70 mM Ca(NO(3))(2) and 70 mM NaHCO(3) aqueous solution. The kinetics of the crystal growth was monitored by means of turbidity measurement. The apparent absorption is gradually increased with the elapsed time after the mixing and reaches its maximum at...
Article
10-Phenoxyphenothiabismine 5,5-dioxide (2a) and related compounds 2b,c, the first example of an air-stable aryloxybismuthane whose bismuth−oxygen bond is not incorporated into a ring system, were synthesized and fully characterized. Substitution of the OAr group in 2 by phenols in solution revealed two substitution tendencies. The substitution with...
Article
The Drosophila eyes absent gene ( eya ) is involved in the formation of compound eyes. Flies with loss-of-function mutations of this gene develop no eyes and form the ectopic eye in the antennae and the ventral zone of the head on target expression. A highly conserved homo-logous gene in various invertebrates and vertebrates has been shown to funct...
Article
The magnetic structure of the free-radical 2,4,6-triphenylverdazyl (TPV) has been investigated by neutron scattering on a single crystal. TPV orders antiferromagnetically at TN=1.78K. The structure is described by a k=0 propagation vector, with the moments pointing along the b-axis.
Article
The Drosophila eyes absent gene ( eya ) is involved in the formation of compound eyes. Flies with loss-of-function mutations of this gene develop no eyes and form the ectopic eye in the antennae and the ventral zone of the head on target expression. A highly conserved homo-logous gene in various invertebrates and vertebrates has been shown to funct...
Article
To evaluate pathologic features of vitreomacular traction syndrome (VMT). Preretinal membranes removed from five patients during vitreous surgery for VMT syndrome were evaluated by electron microscopy (n = 4) and immunohistochemistry (n = 1). Electron microscopic examination revealed large segments of internal limiting lamina (ILL) in three of the...
Article
In the title compounds, [Co(C2O4)(CH5N)(4)]ClO4, (1), and [Co(C2O4)(C2H7N)(4)]ClO4. H2O, (2), the Co atom has a distorted octahedral coordination composed of four amine ligands and one oxalato ligand. The coordination and oxalato bond distances in (1) and (2) are similar to the corresponding distances in [Co(C2O4)(NH3)(4)](+). The Co-N-C angles are...
Article
Full-text available
To investigate the changes in PAX6 expression in the developing human eye. Six developing human eyes from 6 to 22 weeks' gestation were evaluated. Frozen sections were immunohistochemically stained with monoclonal antibody to chick Pax6 (amino acids 1-223). To verify antibody specificity, western blot analysis was carried out using cell lysates fro...
Article
The title compounds, [N,N'-bis (2-pyridylcarbonyl)propane-1,3-diaminato-kappa(4)N]palladium(II) monohydrate, [Pd(C15H14N4O2)] . H2O, and [N,N'-bis(2-pyridylcarbonyl)propane-1, 3-diaminato-kappa(4)N] nickel(II) monohydrate, [Ni(C15H14N4O2)] . H2O, were investigated by means of X-ray diffraction and high-resolution NMR. The Pd-II and Ni-II ions have...
Article
Copper(II) binuclear chromophores [{Cu(H2qpda)}2]4+ (A) and [{Cu(H2iqpda)}2]4+ (B) were isolated from an acidic aqueous solution of an equimolar H2L–CuSO4 mixture, while H2iso-1-qpda gave no copper(II) binuclear complex [H2qpda=1,3-bis(quinoline-2-carboxamido)propane, H2iqpda=1,3-bis(isoquinoline-3-carboxamido)propane, H2iso-1-qpda=1,3-bis(isoquino...
Article
Aniridia is caused by a mutation of the PAX6 gene. Haploinsufficiency of the gene product is thought to result in the aniridia phenotype, because most mutations thus far detected have been large deletions encompassing the entire gene and nonsense, frameshift, or splice errors that result in premature translational termination on one of the alleles....
Article
A 4-month-old female infant was referred to us for abnormal eye movement. The course of pregnancy and birth was uneventful. Both eyes lacked fixation or light reaction. The anterior ocular segment, including the cornea, was normal. Funduscopy showed extremely small optic disc in both eyes. The retinal vessels were narrow and straight, and were pres...
Article
Using electron spin resonance (ESR) and visible spectroscopies, coaxially stacked binuclear copper(II) complexes of ω,ω′-bis(pyridine-2-carboxamido)alkanes in acidic aqueous solution (pH 3.8–5.0), H2peda (alkane = ethane), H2ppda (alkane = propane), and H2pbda (alkane = butane), were characterized. trans-1,2-Bis(pyridine-2-carboxamido)cyclohexane o...
Article
The crystal structure of the nitridochromium(V) complex [CrN(salophen)]·MeCN [H2salophen=N,N′-bis(salicylidene)-o-phenylenediamine] has been determined. The coordination geometry of this complex, similar to those of all the nitridochromium(V) complexes investigated so far, is square pyramidal with the nitride ion occupying the apex. The ESR paramet...
Article
To study the expression of the alpha1-alpha6 chains of type IV collagen in the dermoepidermal junction (DEJ) during human foetal skin development, human foetal (10 and 20 weeks of gestation) and adult skin was immunostained with specific monoclonal antibodies to the alpha1-alpha6 chains of type IV collagen. Intense expression of the alpha4 chain an...
Article
We determined the distribution of glycosaminoglycans and collagens in the developing human vitreous. Eighty human eyes from 5 gestational weeks to 2 postnatal years of age were used. Glycosaminoglycan components were determined by enzyme digestion with hyaluronidase or chondroitinase AC and ABC and immunohistochemistry for chondroitin, chondroitin-...
Article
A series of meta- and para-phenylene-bridged Bi(III)(n) and Bi(V)(n) compounds (n greater than or equal to 2) have been synthesized. Reaction of Ph2BiX (X = Cl, OSO2CF3) with p-Li2C6H4, p-(BrMg)(2)C6H4, or p- and m-(Me2S . Cu)(2)C6H4 generated in situ from dibromobenzenes gave the corresponding para- and meta-phenylene-bridged Bi-n-bismuthanes, Ph2...
Article
We determined the types and distribution of glycosaminoglycans (GAGs) and collagens, in anterior capsular opacification after endocapsular phacoemulsification and aspiration (ECPEA) and intraocular lens implantation. Opacified anterior capsules were removed from human eyes after ECPEA. Immunohistochemical staining was performed to determine GAGs wi...
Article
Hexakis(4-pyridylcarbinoxy)cyclotriphosphazene (PyPN) and terephthalic acid (TPA) self-assembled into polymeric supermolecules through hydrogen bonding between carboxyl and pyridyl groups. Two supermolecular self-assemblies were obtained: crystals 1 composed of 2:1 TPA/PyPN from DMF/ DMSO, and crystals 2 composed of 3:1 TPA/PyPN from DMF. The forme...
Article
The self-assembly between hexakis(4-carboxyphenoxy)cyclotriphosphazene (1) and hexakis(4-pyridylcarbinoxy)cyclotriphosphazene (2) was investigated. FT-IR spectra and elemental analysis of crystals (3) obtained from a solution containing 1 and 2 in equimolar ratio in DMF suggested that all the carboxyl groups in 1 interact with pyridyl groups in 2 t...
Article
To report a rare case of ocular anterior segment anomalies including uveal ectropion of the iris, invasion of the conjunctival epithelia into the cornea, and posterior embryotoxon with a missense mutation of the PAX6 gene. The authors performed polymerase chain reaction-single-strand conformation polymorphism analysis and sequencing of the PAX6 gen...
Article
We reviewed 63 eyes of 48 cases with dysgenesis of anterior ocular segments. Opacity was localized in the central cornea in 14 eyes, in the periphery in 6 eyes, and involved the whole cornea in 33 eyes. Anterior staphyloma was present in 11 eyes. Other ocular complications included microphthalmos 2 eyes, congenital cataract 1 eye, iris atrophy 3 ey...
Article
The crystal structure of the nitridochromium(V) complex [CrN(salen)] (H2salen = N,N′-bis(salicylidene)ethylenediamine) has been determined. This complex crystallizes in the monoclinic system, space group P21/c, a = 9.575(1), b = 12.322(3), c = 12.999(2) Å, β = 103.57(1)°, V = 1490.8(5) Å3, Z = 4; final R2 = 0.059 (R = 0.054), wR2 = 0.082 (wR = 0.04...
Article
The magnetic properties of four diphenylverdazyls (2−5) with electron acceptor groups in the 3-position were studied by measuring the magnetic susceptibility and heat capacity. The crystal structures of 3 and 4 were determined, and for 2 the crystal structure analysis led to an improved refinement. Verdazyl 2 was found to be an antiferromagnet with...
Article
Obvious differences in 3dz ground-state ESR spectra observed at 77K were detected between a powder sample of Cu(II) doped in [Mg(B15C5)(H2O)2](ClO4)2 single crystal and a Cu(B15C5) complex in 60% HClO4. An X-ray diffraction analysis of [Mg(B15C5)(H2O)2](ClO4)2 demonstrated that the complex takes on a seven-coordinate pentagonal bipyramidal geometry...
Article
X-ray structure analyses have been made on single crystals of trans-[Co(3,3-ma)(NO2)2]·H2O (bd1), mer(N)-[Co(2,3-ma)(NO2)2]·1.5H2O (2), mer(N)-[Co(i-2,3-ma)(NO2)2]·H2O (3) and mer-[Co(NO)2)3 (2,3-tri)] (4); where H(3,3-ma) stands for 10-amino-3,7-diazadecanoic acid H2NCH2CH2CH2NHCH2CH2CH2NHCH2COOH, H(2,3-ma) for 9-amino-3,7-diazanonanoic acid H2NCH...
Article
Treatment of tris-(2-alkoxyphenyl)bismuthanes 1 with iodosylbenzene in methylene dichloride at 40 °C led to none of the expected bismuthane oxides 2 but, quite unexpectedly, gave tetrakis-(2-alkoxyphenyl)bismuthonium chlorides 3 in moderate to good yields. In some cases, bismuthonium formates 4 accompanied the main reaction products. Similar treatm...
Article
The molecular and crystal structure of a cobalt(II) complex prepared by the reaction of 1,3,5-triphenylformazan with cobalt dichloride, 2,3,5-triphenyltetrazolium dichloro(1,3,5-triphenylformazanato)cobalt has been determined by means of X-ray diffraction. The complex crystallized ina triclinic space group <P(1)over bar>, with M-r = 728.55, a = 10....
Article
3,4-Bis(methylthio)-and 3,4-dichalcogeno-8,9-dihydro-7,10-dithiafluoroanthene and 3,4-bis(methylthio)- and 3,4-dithio-7,10-dithiafluoroanthene were synthesized as novel donor components for organic conductors. These donors showed low oxidation potentials, and intermolecular van der Waals interaction between the sulfur atoms was observed by X-ray cr...
Article
X-ray structural analyses have been made on single crystals of mer(N)-[Co(5-dptma)(NO2)2] (A), mer(N)-[CoCl(5-dptma)(H2O)] Br (B), mer(N)-[CoCl(5-dptma)(H2O)]ClO4 (C) and mer(N)-[CoCl(5-dptma)(H2O)] NO3 (D), where H(5-dptma) is N,N-bis(3-aminopropyl)glycine. Complex A crystallizes in the monoclinic space group P21/c as a racemate; complex B in the...
Article
ESR and optical absorption measurements were performed for six-coordinate Fe(III)TPP-butyl peroxide complexes formed in the reaction system composed of Fe(III)TPPCl, NaOCH3 and t- or n-butyl hydroperoxide. The presence of four paramagnetic iron complexes was detected in the reaction system. Based on the spectroscopic parameters, the spin state and...
Article
The benzoyl ester of an iron(m) meso-hydroxyoctaethyl-porphyrin complex, containing 18O derived from molecular oxygen, is isolated from the reaction solution of the complex [FeIII(oep)(OOH)(OH)]- which is prepared by reduction of [FeII(oep)(py)(18O2)] with sodium ascorbate.
Article
A new example of a racemate showing unusual enantiomeric resolution phenomenon, in which simple recrystallization of the racemate leads to remarkable enantiomeric enrichment of either enantiomer up to 100% ee in the mother liquor, has been found. This compound is (±)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]-ethyl]dimethylsulfonium p-nitrob...
Article
Purpose. To determine clinical and pathological features of vitreomacular traction syndrome, a distinct clinical entity with partial posterior vitreous separation in combination with persistent macular adherence that causes visual deficit. Methods. Ten eyes of 10 cases (5 males and 5 females, ages from 55 to 83 years) who had vitreous surgery for v...
Article
The fovea is an excavated area of the retina at the posterior end of the visual axis that facilitates visual acuity. Whereas foveal hypoplasia with decreased visual acuity and congenital nystagmus is a common feature of recognized ocular disorders such as albinism and aniridia, isolated foveal hypoplasia which is not associated with other known ocu...
Article
Efficient enantiomeric resolution of the antiallergenic agent (±)-ST, which shows crystalline polymorphism, is accomplished by simple recrystallization. Both stable crystals of the racemic compound and metastable mixed crystals are formed, and the enantiomeric enrichment of the mother liquor virtually reaches 100% ee.
Article
Treatment of triphenylbismuth difluoride with alkenyltrimethylsilanes 1 or trimethylsilyl cyanide–alkenyltrialkylstannanes 3 in the presence of boron trifluoride–diethyl ether gave the corresponding alkenyltriphenylbismuthonium tetrafluoroborates 2 in moderate to good yields. An X-ray crystallographic analysis of the salt 2e confirmed the distorted...
Article
To determine the clinical features and surgical outcomes of retinal detachment associated with atopic dermatitis. One hundred twenty-one eyes of 98 patients with atopic dermatitis and rhegmatogenous retinal detachment were surgically treated and followed up for 1 year or longer. Fundus examination data on retinal breaks and detachment, and follow-u...
Article
The cation radical (CR) and charge transfer (CT) salts of 7,10-dithiafluoroanthene with various inorganic and organic acceptors were prepared either by electrocrystallization in the presence of tetraalkylammonium salts or recrystallization of the mixture of donor and acceptors. The structures of these CR and CT salts were determined by X-ray crysta...
Article
p-Terphenoquinone analogues containing a quinonoid type of tellurophene skeleton in the central position have been prepared with a view to developing a new type of organic pnotoconductive materials having amphoteric redox properties. X-ray structure analysis showed that each molecule exhibited an asymmetric boat conformation owing to the bent struc...
Article
Purpose. To investigate genetic origin of isolated foveal hypoplasia. Methods. We analyzed PAX6 gene, the master control gene in ocular morphogenesis whose haploinsufficiency and missense mutations cause aniridia and Peter's anomaly, in genomic DNA of the family members with an autosomal dominant trait (MTM No. 136520) by SSCP and sequencing analys...
Article
Purpose. To determine the expression and distribution of CD44 molecule, the transmembrane cell adhesion molecule that mediates neuro-glial interaction in the brain, in the human retina. Methods. Four developing human eyes at 6, 10, 16 and 21 weeks gestation, one infantile and 4 adult human eyes were used. Sections of the specimens were immunohistoc...
Article
By recrystallization of certain racemic compound (ST), racemic compound crystals, mixed crystals of two enantiomers, or a mixture of these two types of crystals were obtained, depending on the recrystallization conditions employed. Their crystal forms were determined by X-ray diffraction of the single crystals and powdered materials. The space grou...
Article
We observed a pathological vessel in the left eye of a one-year-old male infant diagnosed as familial exudative vitreoretinopathy, FEVR. A part of inferior temporal retinal vein was floating in the vitreous temporal to the macula. This floating vessel changed its course along with changes in the eye position. An a vascular zone was present in the p...
Article
Abnormal eye position led to the detection of vitreous hemorrhage in both eyes of a 13-month old male infant. Examination under general anesthesia at the age of 22 months led to the detection of foveal retinoschisis, retinoschisis in the periphery, inner retinal hole and retinal fold extending from the disc over the fovea. Congenital retinoschisis...
Article
Treatment of triarylbismuth difluorides 2 with siloxycyclopropanes 3 in the presence of trimethylsilyl trifluoromethanesulfonate (triflate) or boron trifluoride–diethyl ether gave the corresponding triaryl(3-oxoalkyl)bismuthonium salts 4 as crystals. X-Ray crystallographic analysis of the triflate 4a showed that the central bismuth atom has a disto...
Article
A new methodology for the synthesis of cl-asymmetric bicyclic nitroxides is described. Reduction of certain homoallylic nitroenone with 3.0 equiv of SmI2 in THF or THF-Et(2)O at -50 degrees C gave a stable nitroxide radical-enolate intermediate, a kind of radical-anion species. The subsequent addition of electrophiles such as acyl chlorides at -50...
Article
A new type of α-asymmetric bicyclic nitroxides were synthesized by three electron reduction of certain homoallylic nitroenones followed by the reaction with nitro-substituted benzoyl chlorides. Some nitroxides thus obtained turned out to exist as a conglomerate (racemic mixture), an equimolecular mixture of two crystalline enantiomers, and hence in...
Article
The relation between extension of extraretinal vasoproliferation and vitreous fibers in stage 3 mild retinopathy of promaturity was evaluated by light and electron microscopy using 4 eyes obtained after autopsies. Seven developing human eyes from 20 to 40 weeks' gestation were used as controls. At an early stage, when vascular tissues broke the inn...
Article
Hypervalent bond formation has been found to occur at bismuth as the hypervalent center. The transformation of (2-acetylphenyl)bis(4-methylphenyl)bismuthane (2b) to (2-acetylphenyl)bromo(4-methylphenyl)bismuthane (3b) brings about a noticeable change in the electronic nature of the carbonyl function in the 2-acetylphenyl group, which is sensitively...
Article
The magnetic structure of the antiferromagnetic organic radical 2,4,6-Triphenylverdazyl (TPV) has been investigated by neutron diffraction and magnetization measurements. The magnetic structure has been refined by observing several magnetic reflections. The weak ferromagnetism which appears below the Néel temperature is explained by the Dzyaloshins...
Article
The crystal structure of dichloro(5,10,15,20-tetraphenylporphinato)phosphorus(V) chloride dichloromethane solvate has been determined by X-ray diffraction at ambient temperature. A saddle shape of the meso-tetraphenylporphinate disc is attributed to marked S4 deviation from planarity. The mode of the torsion of four phenyl rings around the CC bond...
Article
cis/trans paired diastereoisomeric chlorophenyl[2-[(R)-1-(dimethylamino)ethyl]phenyl]bis-muthanes, 2-[(R)-Me2NCHMe]C6H4BiPhCl (1a), have been characterized by X-ray structure determination. The crystal structure involves the packing of two pairs of discrete mononuclear molecules in the unit cell, and the asymmetric unit contains a pair of diastereo...