Nada Idzdihari Adesti’s research while affiliated with University of Indonesia and other places

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Publications (1)

Fig. 1. Fasting serum glucose concentration on the 3rd day of induction (mg/dL).
Fig. 2. Serum glucose levels in the five groups after 21 days. Diabetes was induced by a single intraperitoneal injection of streptozotocin followed by intraperitoneal administration of nicotinamide. (a) P < 0.05 vs. control. (b) P < 0.05 vs. DM.
Fig. 3. Histopathological Image of Rat Pancreatic Langerhans Islets in Each Treatment Group (HE Staining) (Magnification 400x); A ¼ Group I; B ¼ Group II, score 1; C ¼ Group II, score 2; D ¼ Group V, score 0; 1 ¼ lymphocyte.
Fig. 6. Immunohistochemical image of insulin expression in pancreatic tissue in the treatment groups (Magnification 400x). A: strong positive in Group I, negative in Group II, C: strong positive in Group III, negative in Group V. Diaminobenzidine stains the insulin brown. Slides were counterstained with H&E.
Effect of Inulin from Dahlia Tubers (Dahlia variabilis) Extract on Insulitis Severity and Insulin Expression in Diabetic Rats
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August 2024

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BioMedicine

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Nada Idzdihari Adesti

Background Dahlia (Dahlia variabilis), a widely cultivated ornamental plant in Indonesia, is known to contain 84.08% inulin in its tubers. Numerous studies have demonstrated the antidiabetic potential of inulin from various plant sources. However, most of the research is in the form of a mixture of inulin with other active substances, and no one has analyzed the effects of inulin derived from dahlia tubers. This study examines the effect of inulin from dahlia tuber extract on blood glucose levels, serum insulin expression, pancreatic tissue insulin expression, homeostatic model assessment of insulin resistance (HOMA-IR), and the extent of insulitis in diabetic rats. Methods In this experimental study, 20 male Wistar rats were randomly allocated to five groups. Group I served as the control, Group II as the STZ-induced diabetic group, Group III as the STZ-induced diabetic group treated with inulin (0.5 g/kgBW), Group IV as the STZ induced diabetic group treated with inulin (1.0 g/kgBW), and Group V as the STZ-induced diabetic group treated with inulin (1.5 g/kgBW). The inulin was administered for 21 days. The degree of insulitis was evaluated using a scoring system, serum insulin concentration via ELISA, and insulin expression in the pancreas through immunohistochemistry. Results Administration of inulin from dahlia tubers significantly reduced serum glucose concentrations in diabetic rats. Notably, only inulin extracts at doses of 1 g/kgBW and 1.5 g/kgBW showed a significant reduction in insulitis and HOMA-IR index in diabetic rats, while the 0.5 g/kgBW inulin extract reduced insulitis without affecting HOMA-IR. Inulin extract administration did not affect insulin expression in serum or pancreatic tissue. Conclusions Inulin from dahlia tuber can exert antidiabetic properties by improving insulin resistance and insulitis. These studies suggest the great potential of dahlia tubers as the source of inulin for prebiotic functional foods.

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