Naci Senkal's research while affiliated with Istanbul Medical University and other places

Publications (32)

Article
The suppressor of the cytokine signaling-1 (SOCS1) gene is a short sequence located on chromosome 16 that functions to induce an appropriate immune response and is an essential physiological regulator of interferon (IFN) signaling. In addition to comparing the global DNA and SOCS1 gene promoter methylation status between our patients with coronavir...
Article
Objective: Vitamin D has beneficial effects, some of which involve the cardiovascular system. No study to date has investigated the association between serum endocan levels, as a biomarker of endothelial inflammation, and vitamin D levels in the absence of subclinical atherosclerosis detected by carotid intima-media thickness (CIMT) in healthy ind...
Article
Purpose While the definitive diagnosis of COVID-19 relies on PCR confirmation of the virus, the sensitivity of this technique is limited. The clinicians had to go on with the clinical diagnosis of COVID-19 in selected cases. We aimed to compare PCR-positive and PCR-negative patients diagnosed as COVID-19 with a specific focus on older adults. Meth...
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Erroneous immune responses in COVID-19 could have detrimental effects, which makes investigation of immune network underlying COVID-19 pathogenesis a requisite. This study aimed to investigate COVID-19 related alterations within the frame of innate and adaptive immunity. Thirty-four patients clinically diagnosed with mild, moderate and severe COVID...
Article
Background While there are substantial reports on the acute phase of Covid-19, the data on post-Covid phase are limited. Aim To report the data on older post-Covid patients comparatively with the young adults. Study design Retrospective, single-center study in post-Covid outpatient clinic. Clinical characteristics, laboratory examination, chest i...
Article
Background: The purpose of this study is to evaluate the prognostic roles of hemostatic tests including prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer, and antithrombin III in the progression of disease, monitorization of severe, mild and moderate cases, and also to show their relationship with inflammator...
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Background Acute kidney injury (AKI) in COVID-19 patients is associated with poor prognosis. However, the incidence, risk factors and potential outcomes of AKI in hospitalized patients are not well studied.Materials and methods This is a retrospective cohort study conducted in two major university hospitals. Electronic health records of the patient...
Article
Objective: Severe acute respiratory syndrome (SARS) coronavirus 2 (SaRS-Cov-2) associated respiratory disease (COVID-19), announced as a pandemic, is a multisystem syndrome. SARS-CoV-2 directly infects and damages vascular endothelial cells, which leads to microvascular dysfunction and promotes a procoagulant state. Dipyridamole (DP) acts as a rev...
Article
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with a variety of organ/system involvement. Respiratory system involvement is common in these patients and usually manifests itself by disorders of the lung parenchyma, pleura, pulmonary vasculature or diaphragm. In this study, we sought to determine the frequency of interstit...
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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may trigger a cytokine storm, which is characterized by uncontrolled overproduction of proinflammatory cytokines. Objectives: We aimed to investigate the association between circulating levels of inflammatory cytokines and severity of coronavirus disease 2019 (COVID-...
Article
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For COVID-19 (Coronavirus Disease-2019) cases, detecting host-based factors that predispose to infection is a very important research area. In this study, the aim is to investigate the MBL2 and NOS3 gene polymorphisms in COVID-19 patients with lung involvement, whose first nasopharyngeal PCR results were negative. Seventy-nine patients diagnosed wi...
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Objective Corona Virus Disease-2019 (COVID-19) has been among the major infectious events of the century. In today’s literature where COVID-19 and host factor effects are frequently examined, we aimed to examine another factor: Circadian Clock Protein PERIOD 3 (PER3). There is a significant correlation between PER3 gene polymorphism and circadian r...
Article
Background The prevalence of SLE pulmonary involvement varies depending on several factors, including diagnostic methods [1]. Objectives We aimed to determine the frequency of involvement with different diagnostic methods in a single center cohort. Methods 300 SLE patients were included. Chest x-ray (CXR), lung spirometry, carbonmonoxide diffusio...
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Introduction: Coronavirus has caused a pandemic since it was first detected in Wuhan in December 2019. The mortality rate is high in moderate and severe cases. Our study aimed to screen the CBC parameters as a useful predictive factor for COVID-19 resulting in critical illness. Methods: A total of 285 patients with positive PCR results were analyze...
Article
Background/objectives COVID-19 followed a mortal course in some young patients without any underlying factors, however, it followed a very benign course in some very older individuals with multiple comorbidities. These observations question if some genetic factors may be related to the vulnerability and poor prognosis of the disease. In this study,...
Article
Background: Colistin utilization has gradually increased worldwide with the arising of multidrug-resistant (MDR) gram-negative bacilli despite its nephrotoxicity. Lipid emulsion (LE) is widely used for the toxic overdose treatment of various drugs. Objective: The aim of the present study is to evaluate the effect of lipid emulsion on improvement o...
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Full-text available
Background The information on electrocardiographic features of patients with coronavirus disease 2019 (COVID-19) is limited. Our aim was to determine if baseline electrocardiographic features of hospitalized COVID-19 patients are associated with markers of myocardial injury and clinical outcomes. Methods In this retrospective, single center cohort...
Article
Aim: The purpose of this article was to report the low rates of intensive care unit admission and mortality in intermediate- and high-risk COVID-19 patients, and to share our clinical approach with other colleagues. In addition, we sought to reveal the relationship between myocardial injury and clinical outcomes such as death, intensive care unit...
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Full-text available
Objective Older adults have been continuously reported to be at higher risk for adverse outcomes of Covid-19. We aimed to describe clinical characteristics and early outcomes of the older Covid-19 patients hospitalized in our center comparatively with the younger patients, and also to analyze the triage factors that were related to the in-hospital...
Article
Thrombotic and embolic complications in the cardiovascular system are evident and associated with worse prognosis in coronavirus disease 2019 (COVID-19) patients. Endothelial-specific molecule 1 (endocan) plays a role in vascular pathology. We hypothesized serum endocan levels on admission are associated with primary composite end point (mortality...
Article
Full-text available
Introduction: COVID-19 caused by the SARS-CoV-2 continues to spread rapidly across the world. In our study, we aim to investigate the relationship between the liver enzymes on admission (AST, ALT, ALP, GGT) and severity of COVID-19. We evaluated course of disease, hospital stay, liver damage and mortality. Materials and methods: Our study includ...
Article
Objective Older adults have been continuously reported to be at higher risk for adverse outcomes of Covid-19. We aimed to describe clinical characteristics and early outcomes of the older Covid-19 patients hospitalized in our center comparatively with the younger patients, and also to analyze the triage factors that were related to the in-hospital...
Article
Full-text available
Objective: To investigate the role of chest computed tomography (CT) examinations acquired early after initial onset of symptoms in predicting disease course in coronavirus disease 2019. Methods: Two hundred sixty-two patients were categorized according to intensive care unit (ICU) admission, survival, length of hospital stay, and reverse transc...
Preprint
Full-text available
Objective: Older adults have been continuously reported to be at higher risk for adverse outcomes of Covid-19. We aimed to describe clinical characteristics and early outcomes of the older Covid-19 patients hospitalized in our center comparatively with the younger patients, and also to analyze the triage factors that were related to the in-hospital...
Article
Background: Novel coronavirus 19 infection (COVID-19) has become a global pandemic and Turkey had the first coronavirus patient tested positive in 10 March 2020. Aims: In this analysis we have discussed the characteristics of Turkish patients who have been hospitalized for COVID-19 infection. Study design: Cross sectional study Methods: This r...

Citations

... Instead, the B cell proliferation following T cell activation was investigated. The doses of mitogens and the incubation time point of 120 h were either defined by preliminary experiments or previously described in several previous studies [11][12][13][21][22][23]. ...
... We also found that 62.4 % of the patients had COVID-19 PCR positivity, and 95.2% had a COVID-19 appearance in thorax CT. According to a study conducted in Turkey, COVID-19 PCR positivity was observed at 65%, which is similar to ours (14). The number of studies that we can compare on this subject is limited since the exclusion criterion is COVID-19 PCR negative in most COVID-19 ICU studies. ...
... Nitric oxide is essential in COVID-19, as it develops inflammatory stress to prevent pulmonary hypertension [106,127]. Prooxidant eNOS enzyme is encoded by the NOS3 gene, which is highly polymorphic. rs2070744, rs179983, and a VNTR in the 4 th intron of NOS3 are functional polymorphisms studied individually or as a haplotype in various diseases compared to the reference haplotype consisting of the wild types of these polymorphisms, which is the most common. ...
... They showed that AKI is common in hospitalized patients with COVID-19 and is associated with a longer hospital stay, ICU admission rate and hospital mortality. Similarly, this hospital stay and admission to the ICU is related to the appearance of certain comorbidities and these may vary according to the data collected [2]. ...
... Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been first identified in Wuhan, China at the end of 2019 and caused Coronavirus Disease (COVID)-19 which has a wide clinical spectrum from asymptomatic to mild symptoms, severe pneumonia, respiratory distress syndrome, or death (1)(2)(3). As of April 2022, it has been reported that there are approximately 15 million cases in Turkey and 492 million in the world, and more than 6 million deaths were seen all around the world. ...
... MBL deficiency has also been correlated with enhanced sensitivity to respiratory infections like influenza, SARS-CoV-1, and SARS-CoV-2 [36][37][38][39]. A particular carbohydrate on the surface of the parasites in Leishmania braziliensis' exterior allows serum MBL to attach to it and through antibody-independent pathways, serum MBL activates the complement system [40]. ...
... Regarding the localization of the repolarization abnormality, lateral and antero-lateral changes on the ECG were the most frequently described, being also associated with worse clinical outcomes [92][93][94]. ...
... Based on the results, leukocytosis, neutrophilia, and lymphopenia were more common in elderly adults. Findings related to PT, INR, BUN, and Cr were also significantly higher in elderly patients, consistent with the previous lectures (10,19,20). As an indicator of disease severity, hospitalization in the ICU was found to be more common in elderly patients than in non-elderly patients, reflecting the rapid course and adverse outcome of COVID-19 disease in elderly patients (20). ...
... 309 (3) It is necessary to develop models that recapitulate the effects of comorbidities on SARS-CoV-2 infection. patients with preexisting comorbidities show more severe symptoms when infected, 310,311 but there is very limited knowledge on the effects of comorbidities on SARS-CoV-2 infection in animal models. Rodents are a better choice for such models than other species, since it is easier to establish models of SARS-CoV-2 in rats and mice with cardiovascular disease, 312 cancer, 313 and diabetes. ...
... Thromboinflammation, endotheliopathy and coagulopathy are frequent in severe COVID-19 [18], and thrombotic events are associated with worse prognoses in COVID-19 [19]. Very recently, several studies reported on potential interest in serum endocan as a potential marker in the diagnosis and prediction of disease severity in COVID-19 [20][21][22][23][24][25][26], and most of them also mentioned the importance of this marker's connection with thrombosis. However, none of them specifically focused on the potential role of endocan in identifying thrombotic injury in COVID-19, nor investigate the mechanistic importance of endocan in thromboinflammation. ...