N.P. Jivani's research while affiliated with C. U. Shah College of Pharmacy & Research and other places

Publications (62)

Article
In the present study, carboxymethylchitosan (CMCS) was prepared from chitosan, crosslinked with glutaraldehyde and evaluated in vitro as a potential carrier for site specific drug delivery of lercanidipine hydrochloride (LERH). LERH was incorporated at the time of crosslinking of CMCS. The chitosan was evaluated for its degree of deacetylation (DD)...
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Ethnopharmacological relevanceIn the traditional medicine, Cynodon dactylon (Linn.) is used in asthma, but scientific studies to provide evidence for medicinal uses are sparse. Thus this study was undertaken to provide evidence for medicinal use in asthma as a bronchodilator, and to identify active ingredient(s).Materials and methodsIn vivo, acetyl...
Article
The purpose of this research was to formulate and systematically evaluate in vitro performance of mucoadhesive microspheres of nifed&pine. Cross-linking Nifedipine microspheres containing chitosan were prepared by simple emulsification phase separation technique using glutaraldehyde as a cross-linking agent. A simple lattice design was employed to...
Article
In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the body, but once administered, undergo gelation in situ, to form a gel. The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, electrical sensitivity, enzyme sensit...
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The current study involves the fabrication of oral bioadhesive bilayer matrices of narrow absorption window drug baclofen and the optimisation of their in vitro drug release and characterisation. Statistical design of experiments, a computer-aided optimisation technique, was used to identify critical factors, their interactions and ideal process co...
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Cataract is a visual impairment occurs due to the opacification of crystalline lens. It affects around 17 billion peoples worldwide, although incidence of cataracts is increasing day by day among the elderly persons. Still today except surgery no other effective treatment have been successfully developed so far, thus this present review is focused...
Article
The present study describes a simple, accurate, precise and cost effective UV-Visible spectrophotometric method for the estimation of Riboflavin raw material. The Riboflavin is water soluble vitamin, so the solvent used throughout the experiment was 0.1N NaOH, the absorption maxima of drug was found at 445 nm. Beer's law was obeyed in the range of...
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Elevation of serum homocysteine is considered to contribute to endothelial dysfunction, which is considered to be the initial event in vascular disease following renal transplantation. We sought to investigate whether an association existed between serum homocysteine levels and endothelial dysfunction after renal ischemia/reperfusion (I/R) injury....
Article
Synergistic interactions between the components of mixtures of herb are a vital part of their therapeutic efficacy. There is no real basis for better efficacy of a mixture of herb extract than an equivalent dose of an individual herbal extract. Speculation as to explain this, whether it involves synergy, enhanced bioavailability, cumulative effects...
Article
The aim of the present study was to prepare and evaluate microspheres of Eudragit containing an antiviral drug stavudine. Microspheres were prepared by O/O solvent evaporation method using acetone/liquid paraffin system. The prepared microspheres were characterized for their micromeretic properties and entrapment efficiency; as well by Fourier tran...
Article
The present study was designed to investigate effects of rutin on isoproterenol induced myocardial infarction (MI) by considering enzyme level in rats. Rats were treated with rutin contineously for 10 days (10 mg/kg/day, i.p.,); MI were induced by treating rats with isoproterenol for last 2 consecutive days (5.25 and 8 mg/kg, i.p). Protein kinase C...
Article
The present investigation concerns with the development and optimization of p H specific sodium alginate based in-situ gelling system containing ketorolac tromethamine. The experiments were designed using 3 2 full factorial designs with an objective to retain in stomach for an extended time period. Based on preliminary trial, the concentration of s...
Article
En la presente investigación, se han preparado microesferas de Eudragit (RS 100, RL 100 y RSPO) y etilcelulosa cargadas con 5-fluorouracilo. Se ha utilizado la técnica de �evaporación del disolvente o/o� para preparar las microesferas utilizando el sistema de (metanol + acetona)/ parafina líquida. Se ha utilizado estearato de magnesio como estabili...
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The purpose of the present study was to explore the combined effect of chemical enhancers and iontophoresis on the in vitro permeation of acyclovir gel across porcine skin. Acyclovir gel was formulated using carbopol 940 and hydroxypropyl methylcellulose K4M (HPMC K4M). Effect of drug concentration on the delivery of acyclovir was examined. Increas...
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Background: In view of the reported efficacy of glucagons-like peptide-1 (GLP-1) on ischemia reperfusion (I/R) injury, this study was designed to assess the effect of exenatide (GLP-1 receptor agonist) on renal I/R in type 2 diabetes mellitus (T2DM). Materials and Methods: T2DM in rats were induced by administration of nicotinamide (230 mg/kg, i.p....
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It was demonstrated that fenofibrate and telmisartan exerted renoprotective effects in ischemia/reperfusion (I/R) injury. Because the combination of fenofibrate and telmisartan synergistically enhanced peroxisome proliferator-activated receptor (PPAR) activation, we hypothesized that the combination of both drugs may exert prolonged beneficial effe...
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This study was designed to investigate the possible effect of exenatide (Glucagon like Peptide-1 receptor agonist) on liver injury (distant organ) induced by renal ischemia reperfusion (IR) in diabetic rats. In vivo renal IR was performed in both type 2 diabetic and normal rats. Each protocol comprised ischemia for 30 minutes followed by reperfusio...
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The present study deals with development of a floating in-situ gel of the narrow absorption window drug baclofen. Sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which varying concentrations of drug and calcium bicarbonate were added. Fourier transform infrar...
Article
Azadirachta indica had ample therapeutic action since many years. Hepatoprotective effect of methanolic and aqueous extracts of azadirachta indica leaves was evaluated using Male Wistar rats. Result indicate that the plant good potential to act as hepatoprotective agent.
Article
Cancer is still considered as one of the most dreadful disease despite the current improved method of precaution, surgery and therapy. Plants have provided to mankind a large variety of potent drugs to alleviate suffering from diseases. In spite of spectacular advances in synthetic drugs in recent years, some of the drugs of plant origin have still...
Article
A multiple-unit-type oral floating dosage form (FDF) of 5-Fluorouracil (5-FU) was developed to prolong gastric residence time for the treatment of stomach cancer. The floating microspheres were prepared by solvent evaporation method. The prepared microspheres were characterized for their micromeretic properties, floating behavior and entrapment eff...
Article
Ethanolic extract of Triumfetta rhomboidea Jacq was subjected to various phytochemical tests. Preparative Thin layer Chromatography study of the extract was performed and active constituents were isolated. Spectral analysis of the isolated constituent indicates that Triumfetta rhomboidea (Tiliaceae) contains carbohydrate glycosides, phytosterol, st...
Article
A series of methyl 2-substituted benzimidazole-1-carbodithioates were successfully synthesized. Benzimidazoles were prepared by condensation of o-phenylenediamine with substituted Carboxylic acid and by condensation of substituted benzaldehyde, Sodium metabisulphate and o-phenylenediamine. Methyl Carbodithioate derivative of the benzimidazole were...
Article
The aim of present study was to examine the influence of variation of gastric pH over the range 1-3.5 on the gelation of liquid formulations of sodium alginate and on the in vitro release of baclofen from the resultant gels. Gels suitable as vehicles for sustained delivery of these drugs were formed in vitro at pH < 3.5 from sodium alginate solutio...
Article
The series of seven substituted 2-phenyl-benzothiazole and substituted 1, 3-benzothiazole-2-yl-4-carbothiaote derivatives were synthesized. Substituted 2-phenyl-benzothiazole were synthesised by condensing substituted benzoic acid with 2-amino thiophenol in the presence of phosphoric acid and 3-benzothiazole-2-yl-4-substituted carbothiaote derivati...
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Background: Traditionally the aqueous and alcoholic extracts as well as seed oil of Ocimum sanctum is reported to modulate the immune response. So the present study was undertaken to compare the immunomodulatory activity between alcoholic and aqueous extract of Ocimum sanctum. Objective: To comparatively evaluate the mmunomodulatory activity of alc...
Article
Cancer is a malignant disease that is characterized by rapid and uncontrolled formation of abnormal cells which may mass together to form a growth or tumour, or proliferate throughout the body. Next to heart disease cancer is a major killer of mankind. Present study aims at a preliminary phytochemical screening and anticancer evaluation of Adiantum...
Article
A series of methyl 2-substituted benzimidazole-1-carbodithioates were successfully synthesized. Benzimidazoles was prepare by condensation of o-phenylenediamine with substituted Carboxylic acid and by condensation of substituted benzaldehyde, Sodium metabisulphate and o-phenylenediamine. Methyl Carbodithioate derivative of the benzimidazole were pr...
Article
The current study involves the development of oral bioadhesive hydrophilic matrices of repaglinide and the optimization of their in vitro drug release and ex vivo bioadhesion. A simplex lattice design was employed to systematically optimize the drug delivery containing two polymers and a filler. The proportions of polyethylene oxide (PEO), microcry...
Article
This study was designed to investigate possible effect of hyperlipidemia on renal ischemia/ reperfusion injury in rat. Male Wistar albino rats were divided into 4 groups. Hyperlipidemia was induced by cholesterol (500 mg kg<sup>-1</sup> p.o.) feeding in hydrogenated ground nut oil (as a vehicle) for 4 weeks. At the end of 4th week renal ischemia/re...
Article
Artemisia Nilagirica (Clarke) plant posses various pharmacological properties like antileishmanial activity, antimalarial, anthelmintic, antiseptic, expectorant, astringent, and anti-inflammatory. Phytochemical screening of Artemisia Nilagirica was carried out. Results indicate that this plant contains flavonoids, steroids, terpenoids, saponins, ta...
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Free radicals are implicated for many diseases including diabetes mellitus, arthritis, cancer, ageing. etc. In the treatment of these diseases, antioxidant therapy has gained utmost importance. Alcoholic extract of Medicago sativa was studied for its in vitro antioxidant activity using different models viz. DPPH radical scavenging, ABTS radical sca...
Article
Eugenia jambolana and Aegle marmelos are used extensively in the indigenous system of medicine as an anti-diabetic agent. The current investigation focuses on the serum insulin augmentation, anti-hyperglycemic and anti-hyperlipidemic property of a combined aqueous extracts of E. jambolana and A. marmelos (EA) on alloxan induced diabetic rats. The d...
Article
Microneedle-based vaccination with the current anthrax vaccine produced an equally effective immune response to intramuscular injection in rabbits using smaller dosage say researcher from Maryland and North Carolina. In the study researchers compared the efficacy of immunizing rabbits with the current anthrax vaccine intradermally using a microneed...
Article
Background: In view of the reported efficacy of peroxisome proliferator-activated receptor-α in renal ischemia/ reperfusion (I/R) injury, the present study was designed to investigate the effect of fenofibrate on cardiac damage induced by renal I/R in hyperlipidemic rats. Methods: Male Wistar rats were divided into five groups: Group 1, normal cont...
Article
Oral delivery is the most convenient and the most acceptable route. However, insulin by itself is degraded by intestinal enzymes and is not absorbed intact across the gastrointestinal mucosa. Now, a day gelatin, trypsin coated capsule, pill, pellets may be available. It has some disadvantages; a lot of the insulin will be wasted before it gets wher...
Article
The pulmonary route of administration offers several advantages. First, the lung has a large surface area for drug absorption, ranging from 100 to 140 m2. In addition, the alveolar epithelium has permeability that allows for rapid absorption of solutes. Because the mucociliary clearance of the alveolar lung tissue is slower than that of the bronchi...
Article
To investigate the role of the methanolic fruit extract of Benincasa cerifera on lipid peroxidation (LPO) and renal pathology in ischemia/reperfusion (I/R).In experimental methodology, both renal pedicles were occluded for 60 min followed by 24 h of reperfusion. B . cerifera (500 mg/kg/day) was administered orally for 5 days prior to induction of r...
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The aim of present study is development of simple, rapid and accurate HPTLC method for estimation of Protocatechuic acid in various extracts of Amumum subulatum Roxb. fruit constituents(Family Zingiberacea), commonly known as 'Badi Elaichi'. The powdered drug was subjected to extraction by soxhlet apparatus using methanol and acetone separately as...
Article
Various herbal drugs individually or in combination have been recommended for the treatment of different disease. The C.congesta commonly known as "karanda" has been recognized in different system of traditional medicine to cure various diseases. It contains several phytochemical constituents belonging to terpenoids category. The root is attributed...
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Evidence suggests that reactive oxygen species play a role in the pathophysiology of renal ischemia/reperfusion (I/R) injury. This study was designed to investigate the renoprotective activity of methanolic fruit extract of Benincasa cerifera in I/R-induced kidney failure in rats. Renal pedicles of 12 rats were occluded for 60 minutes followed by 2...
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The aim of present study was development of simple, rapid and accurate HPTLC method tor estimation of Protocatechuic acid in various extracts of Amuimtm subulatum Roxb. fruit constituents (Family Zingiberacea), commonly known as Badi Elaichi or Greater Cardamom. The powdered drug was subjected to extraction by soxhlet apparatus using methanol and a...
Article
Asthma is a pulmonary disease characterized by reversible airway obstruction, airway inflammation, and increased airway responsiveness to a variety of stimuli. Pulmonary delivery of drugs plays an indispensable role in the management of asthma. ß Adrenoceptor agonists and corticosteroids are two common classes of drugs administered via the lungs. P...
Article
Advancements in the development of ultra-fine drug molecules and peptides suitable for pulmonary delivery have created the requirement for novel handling, metering and drug dispensing techniques; while circumventing the problem of agglomeration (usually solved by mixing the active drug formula with Excipient. Inhalation has long been established in...
Article
Objective: The present work was designed to investigate the role of Diabetes Mellitus Type-II (DM-II) on renal ischemia reperfusion (I/R)-associated pathophysiology in renal damage. Materials and Methods: DM-II in rats was induced by the administration of nicotinamide (230 mg /kg, i.p.), 15 min prior to a single dose of streptozotocin (65mg/ kg, i....
Article
To investigate protective effect of Benincasa cerifera (BC) against kidney injury induced by Ischemia/Reperfusion (I/R) in hyperlipidemic (HC) rats. Hyperlipidemia was developed by cholesterol diet (2% cholesterol and 20 % coconut oil) feeding for 3 weeks. At the end of 3rd week, renal ischemia was induced by both renal arteries occlusion for 60 mi...
Article
Objective: This study was designed to assess the effect of polyherbal formulation (PHF) on simvastatin hepatotoxicity in rats and to assess the possibility of co-administration of PHF along with hepatotoxic drugs. Methods: Hepatotoxicity in rats was induced by simvastatin (20 mg/kg p.o. for 30 days) and the protective effect of PHF (0.25 ml/kg/p.o....
Article
Objective: This study was designed to investigate the effect of diabetes on liver injury (distant organ) induced by renal Ischemia Reperfusion injury (IR) in rat. Materials and Methods: In vivo renal IR was performed in both type-2 diabetic and normal rats. Each protocol comprised ischemia for 30 min followed by reperfusion 24 hrs. Results: The lip...
Article
Introduction: Ischemia/reperfusion (I/R) injury induces an inflammatory response and production of oxygen-derived reactive species, which affect many organs including heart, brain, kidney and gastrointestinal tract. The aim of this study was to assess the distant effect of renal I/R injury. Materials and methods: Male Wistar rats were divided into...
Article
Objective: To evaluate effect of Polyherbal Formulation (PHF) on isoniazid induced hepatotoxicity in rats and assessment of any possibility of co administration of PHF along with such hepatotoxic drug.Materials and Methods: Hepatotoxicity in rat was induced by Isoniazid (INH) (200mg/kg/p.o. for 24 days) and protective effect of PHF (0.25ml/kg/p.o....
Article
Drug delivery to the lungs by inhalation has attracted tremendous scientific and biomedical interest in recent years. This trend accompanies a rise in respiratory illnesses, dramatized by an increase in asthma population in the United States of 46% between 1982 and 1993 (Centers for Disease Control and Prevention, Atlanta, GA). Of at least equal im...
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The present study was designed to investigate anti anxiety effects of alcoholic and aqueous root extracts of Cardiospermum halicacabum in mice. Mice were treated with the alcoholic or aqueous extract (100 or 300 mg/kg p.o.) 1 hr before subjecting the animals to various anxiety models. Anti anxiety activity was evaluated using elevated plus maze (EP...
Article
Large, porous particles with a mean geometric diameter of 10 µm. An increase in the size of aerosol particles results in a reduced fractional surface area (or likelihood) of particle-particle contact in a dry powder (or liquid suspension) and thus in less tendency to aggregate. This diminished aggregation means that less energy is required to aeros...
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Full-text available
A rapid, precise, accurate and specific first-order derivative spectrophotometric method was developed for the determination of Entacapone in pharmaceutical formulation. The technique was applied using 0.01M NaOH as diluent. The first-order derivative spectra were obtained at N = 10, ∆λ = 4.0 nm, and determination were made at 375.0 nm. The method...
Article
Inhalers are designed to disperse fine, respirable powders in a reproducible fashion for optimal systemic or local lung delivery. Together with our particle technologies, they create an integrated pulmonary delivery system. We also offer expertise in systems integration of pulmonary therapeutics with Metered Dose Inhalers (MDIs), including stable f...
Article
Microemulsions are clear, thermodynamically stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a co-surfactant. They offer numerous advantages like improved solubilization of both hydrophilic and lipophilic drugs, better bioavailability, prolong and targeted release, enhanced permeation across biological membran...

Citations

... Regulation of dopamine plays a crucial role in our mental and physical health. Both adrenaline and dopamine are called as catecholamines [1][2][3] . The crystal and molecular structures of adrenaline have been determined by X-ray diffraction methods [4][5][6] . ...
... 5 "Antioxidants are reducing agents which are add up to the drug or other pharmaceuticals to avert their oxidation through oxidative process". 6 For convenience, antioxidants have been traditionally divided into two classes, primary or chain breaking antioxidants and secondary or preventative antioxidants. Secondary or preventative antioxidants are compounds that retard the rate of oxidation. ...
... Therefore, an attempt was made in this study to develop a sustained release of hydrocortisone in-situ gel for the treatment of aphthous ulcer by using different concentrations of methyl cellulose. 22 ...
... Very important phyto-nutrients such as flavonoids, steroids, saponins and alkaloids are found in B. hispida (Battu et al., 2007). B. cerifera functions as a reactive oxygen species of scavenger and is seriously resistive to oxidizing agent (Bhalodia et al., 2009). The plant plays a role in tissue protection via antioxidant action followed by inhibitory action on colchicine that persuade Alzheimer's disorder (Lim, 2007). ...
... Study on the effects of rutin on isoproterenol-induced myocardial infarction showed that pretreatment with rutin enhanced survival of the rats and decreased the level of protein kinase C and malonylaldehyde enzyme while the elevation of glutathione and superoxide dismutase level as compared to that in isoproterenol-treated group. The results indicate that rutin significantly reduces myocardial infarction and emphasize the beneficial action in the prevention of myocardial infarction (Malaviya et al., 2011). Diabetic cardiomyopathy (DCM) is a dreadful complication of diabetes. ...
... 25 Synthesis of 2-substituted benzimidazoles from ortho-phenylenediamine [2(k-x),2i,2g] 2-substituted benzimidazoles were synthesized by the reaction of o-phenylenediamine and substituted benzaldehyde by the procedure reported in literature. [26][27][28] Synthesis of mannich base of 2-substituted benzimidazoles with benzamide [3(a-x)] 2-substituted benzimidazole (0.01 mole) was added to the ethanolic solution of benzamide (0.01mole). Formaldehyde (37%) (0.01 mole) was added and the reaction mixture was then adjusted to the pH of 3.5 with conc. ...
... Kandungan metabolit sekunder T. rhomboidea Jacq. di antaranya glikosida karbohidrat, fitosterol, steroid, flavonoid, tanin, senyawa fenolik, dan triterpenoid (Devmurari et al. 2010;Joy et al. 2011;Estella et al. 2017). ...
... our group already reported one compound luteolin as a potent antimalarial lead compound against P. falciparum using in silico and in vitro analysis [16]. On the other hand, A. nilagirca is reported to have several important biological activities like antioxidant, cytoprotective, anti-inflammatory, antiproliferative, antibacterial, anticancer etc. [17][18][19][20][21][22][23][24][25]. Apart, this plant also possesses larvicidal, pupicidal, adulticidal and mosquito repellant activity [26][27][28]. ...
... A triterpenic ether, lanost-20(22)-en-3, 19-ether, named adiantulanostene ether was isolated from A.venustum. 5,6 Abelmoschus moschatus ...
... The karanda was initial fruite in the Philippines in 1915. 5 Fruits are rich source of iron and vitamin C, therefore, ethnomedical the fruits are used for curing anemia, as an astringent, antiscorbutic, and as a remedy for biliousness. Its leaf decoction is used in contradiction of fever, diarrhea, and earache, whereas roots help as a stomachic, vermifuge, remedy for itches, and insect repellent. ...