N de Tribolet’s research while affiliated with University of Geneva and other places

... This is the less traumatic route to the sella turcica, avoiding brain retraction, and also permitting good visualization, with lower rates of morbidity and mortality when compared to the transcranial route, besides faster postoperative recovery 4 . It also avoids the use of the nasal speculum and postoperative tamponade 5 . ...

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Endoscopic transnasal approach for removing pituitary tumors

... Temozolomide (TMZ) is an orally administered methylating agent that has shown promising responses in a subset of adults with recurrent or newly diagnosed high-grade glioma [18][19][20][21][22]. The addition of temozolomide to RT for newly diagnosed adult glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity. ...

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Does Simultaneous Intensity Modulated Radiotherapy with Temozolomide Increase the Radiosensitivity of Childhood Diffuse Intrinsic Pontine Glioma (DIPG)?- a Clinical Case from our Practice

... Sample authentication is necessary to validate the data produced in any research project using human biosamples. Sample misidentification or mixup are unfortunately common problems in biomedical research [1][2][3][4][5] and can eventually lead to the publication of incorrect results 1,2,6,7 Despite the cross-contamination of biological samples being a widely recognized problem 8 , only a minority of scientists perform tests to validate the identity of the samples analyzed prior to their studies 9,10 . Cell lines are considered "misidentified" when their genetic profile differs from that of the individual donors from whom they were initially established. ...

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Human sample authentication in biomedical research: comparison of two platforms

... While several signaling pathways have been involved in GSC maintenance such as TGF-β, Hedgehog-GLI1 or Wnt/β-catenin [19,[64][65][66], Notch signaling emerges as a critical pathway in the regulation of GSC self-renewal [17,19,20,67]. As we observed JM2 can significantly inhibit self-renewal capacity of GSCs using limiting dilution assays, we investigated the effect of JM2 on Notch signaling. ...

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Cytoplasmic connexin43-microtubule interactions promote glioblastoma stem-like cell maintenance and tumorigenicity

... The trajectory was infrafloccular, along the choroid plexus, and obliquely, from below, so as not to stretch the CN VIII nerve complex and the labyrinthine artery. 5,34,41,46,54 Although not the topic of this paper, the effects of MVD on HFS were also evaluated. A satisfactory outcome was obtained in 87.5% of the patients. ...

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Hypertension of neurogenic origin: effect of microvascular decompression of the CNIX-X root entry/exit zone and ventrolateral medulla on blood pressure in a prospective series of 48 patients with hemifacial spasm associated with essential hypertension

... The expression level of Ki67 is known to differ significantly among benign, atypical, and anaplastic meningiomas [38]. Ki67 labeling indices show a highly significant increase from benign (GI) (mean, 3.8%), through or atypical (GII) (mean, 7.2%), to anaplastic (GIII) (mean, 14.7%) meningiomas [39]. Abry et al., ...

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Ki67 Proliferative Index and Peritumoral Brain Edema in Meningiomas: Do They Correlate? A Clinical Study on 56 Patients

... More detailed review of the literature revealed regression of germinoma after exposure to the radiation for diagnostic angiography. 11 In addition, regression of germinoma after only 1 CT scan was available with graphically displayed and illustrative figures. 12 I agree with their suggestion that new imaging should be recommended before further treatment, especially for patients with symptomatic improvement. ...

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Letter to the Editor Regarding “Spontaneous Regression in Intracranial Germinoma: Case Report and Literature Review”

... A panel of eight simple tandem repeats (STRs) and amelogenin for gender determination is adequate to distinguish and differentiate human cell lines, and protocols and commercial kits for authentication are widely available [18]. Papers have had to be retracted because of cell line contamination [19], and simple authentication assays have shown that results originally attributed to KU7 human cells should be attributed to HeLa cells because of contamination [20]. Recommendations are in place for authentication of human cell lines in an effort to avoid misidentification and spurious results [21]. ...

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Molecular characterization and genetic authentication assay for Anopheles ‘hemocyte-like’ cell lines 4a-3A and 4a-3B

... 3,15 Various approaches for the surgical resection have been developed, with the most common being occipital transtentorial and infratentorial supracerebellar. 48 The occipital transtentorial approach to pineal region surgery has undergone several modifications since its introduction in 1937. 14,29,33,49 Various surgical positions, such as sitting, prone, Concorde, and three-quarter prone, have been utilized for this approach, with the latter favored by some due to gravity-assisted occipital lobe retraction. ...

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Pineal Apoplexy: Highlighting the Causes, Treatment, and Outcome

... Growth differentiation factor 15 (GDF15), a member of the transforming growth factor superfamily, has been extensively researched in terms of its relationship with obesity, cachexia, and vascular diseases [21]. GDF15 could enhance the malignancy of gliomas [22], and elevated levels of GDF15 in cerebrospinal fluid are conspicuously associated with poorer prognoses in GBM [23]. Considering that diverse types of frailty indicators might influence the prognosis of cancer patients via distinct mechanisms, a scoring system founded on various types of frailty indicators can offer a more accurate and comprehensive assessment of survival. ...

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Comprehensive Evaluation of Frailty and Sarcopenia Markers to Predict Survival in Glioblastoma Patients