N Birbaumer's research while affiliated with Wyss Center for Bio and Neuro Engineering and other places

Publications (284)

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Autism Spectrum Disorders are characterized by a persisting triad of impairments of social interaction, language as well as inflexible, stereotyped and ritualistic behaviors. Increasingly, scientific evidence suggests a neurobiological basis of these emotional, social and cognitive deficits in individuals with Autism Spectrum Disorders. The aim of...
Chapter
Brain machine interfaces (BMIs) have previously been utilized to control rehabilitation robots with promising results. The design and development of more dexterous and user-friendly rehabilitation platforms is the next challenge to be tackled. We built a novel platform that uses an electro-encephalograpy-based BMI to control a multi-degree of freed...
Chapter
Myoelectric control constitutes a promising interface for robot-aided motor rehabilitation therapies. The development of accurate classifiers and suitable training protocols for this purpose are still challenging. In this study, eight healthy participants underwent electromyography (EMG) recordings while they performed reaching movements in four di...
Conference Paper
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dependent way. At present, only few studies investigated the effects of tDCS on the modulation of functional connectivity between remote cortical areas. Objective: In the present study we aimed to investigate the impact of bipolar tDCS on cortical networks connectivity through graph theoretical analysis. Materials & methods: High-density EEG record...
Article
Question Recent neuroimaging studies have suggested that the anterior prefrontal cortex (aPFC; BA 9/10) is involved in deception and moral cognition. However, since neuroimaging techniques only allow correlative statements, the functional contribution of the aPFC to deception and moral cognition remains elusive. Methods In the first experiment we...
Article
Brain-computer interfaces (BCIs) use brain activity to control external devices, facilitating paralyzed patients to interact with the environment. In this chapter, we discuss the historical perspective of development of BCIs and the current advances of noninvasive BCIs for communication in patients with amyotrophic lateral sclerosis and for restora...
Conference Paper
Full-text available
Question Recent neuroimaging studies have suggested that the anterior prefrontal cortex (aPFC; BA 9/10) is involved in deception and moral cognition. However, since neuroimaging techniques only allow correlative statements, the functional contribution of the aPFC to deception and moral cognition remains elusive. Methods In the first experiment, we...
Article
Coherence of neural activity between circumscribed brain regions has been implicated as an indicator of intracerebral communication in various cognitive processes. While neural activity can be volitionally controlled with neurofeedback, the volitional control of coherence has not yet been explored. Learned volitional control of coherence could eluc...
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We investigated neurophysiological brain responses elicited by a tactile event-related potential paradigm in a sample of ALS patients. Underlying cognitive processes and neurophysiological signatures for brain-computer interface (BCI) are addressed. We stimulated the palm of the hand in a group of fourteen ALS patients and a control group of ten he...
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Introduction: Brain-machine interfaces (BMIs) use brain activity to control external devices, facilitating paralyzed patients to interact with the environment. In this review, we focus on the current advances of non-invasive BMIs for communication in patients with amyotrophic lateral sclerosis (ALS) and for restoration of motor impairment after se...
Conference Paper
Movement related cortical potentials (MRCPs) have been studied for many years and proposed as reliable and immediate indicators of cortical reorganizations in motor learning and after stroke. It has been reported that decrease in amplitude and later onset of MRCPs reflect less mental effort and shorter planning time during a motor task. In this stu...
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Movement related cortical potentials (MRCPs) have been studied for many years and controlled using brain computer interfaces (BCIs). Furthermore, MRCPs have been proposed as reliable and immediate indicators of cortical reorganizations in motor learning and after stroke. In this study MRCPs preceding and during hand movements in severe chronic stro...
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Objective Regardless of the paradigm used to implement a brain–computer interface (BCI), all systems suffer from BCI-inefficiency. In the case of patients the inefficiency can be high. Some solutions have been proposed to overcome this problem, however they have not been completely successful yet. Methods EEG from 10 healthy users was recorded dur...
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Objective: Neuroimaging studies have demonstrated alterations in brain activity in obese (OB) subjects that might be causally linked to their disorder. Roux-en Y gastric bypass (RYGB) surgery induces a marked and sustained weight loss and may affect brain activity. The aim of this study was to compare brain activity pattern between severely OB wom...
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Objective: Brain-computer interface (BCI) provide a non-muscular communication channel for patients with impairments of the motor system. A significant number of BCI users is unable to obtain voluntary control of a BCI-system in proper time. This makes methods that can be used to determine the aptitude of a user necessary. Methods: We hypothesized...
Chapter
In questo capitolo, descriveremo cos’è un’interfaccia cervello-computer e come questa sia considerata una tecnologia assistiva. Inizialmente, porremo l’accento sulla definizione di que-sta TA: una BCI è un sistema di comunicazione indipendente dalle normali vie di comunicazio-ne del cervello che sfruttano i nervi periferici e i muscoli. Spiegheremo...
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This chapter reviews measurement of and interventions by brain-computer interface (BCI) in different states of consciousness associated with severe neurological diseases. The two dimensions of consciousness are awareness and wakefulness. Patients in a vegetative state (VS) and with locked-in syndrome (LIS) do not differ in their wakefulness but wit...
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The BCI competition IV stands in the tradition of prior BCI competitions that aim to provide high quality neuroscientific data for open access to the scientific community. As experienced already in prior competitions not only scientists from the narrow field of BCI compete, but scholars with a broad variety of backgrounds and nationalities. They in...
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A combination therapy of morphine with an NMDA-receptor antagonist might be more effective than morphine without a NMDA-receptor antagonist for the relief of neuropathic pain in patients with complex regional pain syndrome (CRPS). In order to test the efficacy of this combination therapy we performed a double-blind randomized placebo-controlled stu...
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Neuropathic pain is accompanied by both positive and negative sensory signs. To explore the spectrum of sensory abnormalities, 1236 patients with a clinical diagnosis of neuropathic pain were assessed by quantitative sensory testing (QST) following the protocol of DFNS (German Research Network on Neuropathic Pain), using both thermal and mechanical...
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Several studies have shown that motor-skill training over extended time periods results in reorganization of neural networks and changes in brain morphology. Yet, little is known about training-induced adaptive changes in the vocal system, which is largely subserved by intrinsic reflex mechanisms. We investigated highly accomplished opera singers,...
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We hypothesised that living with type 2 diabetes would enhance responses to pictures of foods in brain regions known to be involved in learnt food sensory motivation and that these stronger activations would relate to scores for dietary adherence in diabetes and to measures of potential difficulties in adherence. We compared brain responses to food...
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Brain-computer interface methodology based on self-regulation of slow-cortical potentials (SCPs) of the EEG (electroencephalogram) was used to assess conditional associative learning in one severely paralyzed, late-stage ALS patient. After having been taught arbitrary stimulus relations, he was evaluated for formation of equivalence classes among t...
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Calendar calculation is the ability to quickly name the day that a given date falls on. Previous research has suggested that savant calendar calculation is based on rote memory and the use of rule-based arithmetic skills. The objective of this study was to identify the cognitive processes that distinguish calendar calculation in savant individuals...
Article
To investigate the relationship between physical impairment and brain-computer interface (BCI) performance. We present a meta-analysis of 29 patients with amyotrophic lateral sclerosis and six patients with other severe neurological diseases in different stages of physical impairment who were trained with a BCI. In most cases voluntary regulation o...
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Brain-computer interface methodology based on self-regulation of slow-cortical potentials (SCPs) of the EEG was used to assess cognitive abilities of two late-stage ALS patients. A monitor presented visual information in two targets. Patients used their SCPs to steer a cursor to one of the targets. Within-subject methodology tested the ability to d...
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The current study evaluates the efficacy of a P300-based brain-computer interface (BCI) communication device for individuals with advanced ALS. Participants attended to one cell of a N x N matrix while the N rows and N columns flashed randomly. Each cell of the matrix contained one character. Every flash of an attended character served as a rare ev...
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Brain-computer interfaces based on fMRI enable real-time feedback of circumscribed brain regions to learn volitional regulation of those regions. This is an emerging field of intense research, with potential for multiple applications in neuroscientific research in brain plasticity and reorganization, movement restoration due to stroke, clinical reh...
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Brain–computer interfaces (BCIs) can be used for communication in writing without muscular activity or for learning to control seizures by voluntary regulation of brain signals such as the electroencephalogram (EEG). Three of five patients with epilepsy were able to spell their names with electrocorticogram (ECoG) signals derived from motor-related...
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We have developed an internet browser that functions in conjunction with a brain-computer interface, enabling world wide web access through real-time classification of the P300 event related potential. Standard page navigation tools, hyperlink selection and page scrolling are available through user selection of symbols presented on a separate scree...
Article
Nach intranasaler Applikation erreicht Insulin das Gehirn ohne relevante Effekte auf den peripheren Glucosestoffwechsel. Mittels funktioneller Magnetresonanztomographie (fMRT) untersuchten wir die Aktivierung des Gehirns durch Essensbilder nach intranasaler Applikation von Insulin oder Placebo. Es wurden 11 schlanke Probanden (6m, 5 w, Alter 18–34J...
Conference Paper
A set of different algorithms was involved to analyze the anomalous motor control in four young hemi-paretic patients with pre-and perinatally acquired brain lesions. The effects of a peculiar cerebral reorganization allow the patients to move the paretic arm. Patients performed a pinch grip using their paretic and non-paretic hands alternatively....
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The cerebral networks involved in motor control were analyzed in four young hemi-paretic patients (21-25 years) with pre- and perinatally acquired brain lesions (3 with left periventricular brain lesions, 1 with left schizencephaly) by means of MEG source coherence analysis. Previous TMS and fMRI studies on the same patients had investigated their...
Conference Paper
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A direct comparison of the decoding performance of EEG and MEG in respect of hand movements is provided in this study. We recorded simultaneously EEG and MEG signals of the human contralateral motor cortex during center-out movements (four targets) and decoded directions by regularized linear discriminant analysis. Similar maximum decoding power (D...
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Activation maps of 16 professional classical singers were evaluated during overt singing and imagined singing of an Italian aria utilizing a sparse sampling functional magnetic imaging (fMRI) technique. Overt singing involved bilateral primary and secondary sensorimotor and auditory cortices but also areas associated with speech and language produc...
Article
Hyperexcitability of N-methyl-d-aspartate acid (NMDA) receptors may play an important role in the development of phantom limb pain (PLP). To investigate whether early treatment with the NMDA antagonist memantine attenuates phantom pain memory formation in traumatic amputees. In a randomized, double-blind, controlled trial 19 patients with acute tra...
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Interactive paradigms inducing reactive aggression are absent in the brain mapping literature. We used a competitive reaction time task to investigate brain regions involved in social interaction and reactive aggression in sixteen healthy male subjects with fMRI. Subjects were provoked by increasingly aversive stimuli and were given the opportunity...
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An overview of different approaches to brain-computer interfaces (BCIs) developed in our laboratory is given. An important clinical application of BCIs is to enable communication or environmental control in severely paralyzed patients. The BCI ´Thought-Translation Device (TTD)´ allows verbal communication through the voluntary self-regulation of br...
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A post-traumatic vegetative state that holds for more than 12 months is defined as “permanent”, implying a very low probability of regaining consciousness. Here we report on a patient who emerged from a traumatic vegetative state after 20 months. Beginning from the 6th month, we observed an improvement in the event-related potentials (ERPs) of his...
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The nationwide multicenter trials of the German Research Network on Neuropathic Pain (DFNS) aim to characterize the somatosensory phenotype of patients with neuropathic pain. For this purpose, we have implemented a standardized quantitative sensory testing (QST) protocol giving a complete profile for one region within 30 min. To judge plus or minus...
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In recent studies a central nervous system involvement in the pathogenesis of Complex Regional Pain Syndrome (CRPS) was suggested, stimulating the introduction of central acting drugs. Animal studies have demonstrated an increased expression of the N-methyl-D-aspartate (NMDA) receptors in experimental neuropathic pain. The aim of this study was to...
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We summarize results from a series of related studies that aim to develop a motor-imagery-based brain-computer interface using a single recording session of EEG or ECoG signals for each subject. We apply the same experimental and analytical methods to 11 non-paralysed subjects (8 EEG, 3 ECoG), and to 5 paralysed subjects (4 EEG, 1 ECoG) who had bee...