Myung-Guk Han's research while affiliated with Korea Centers for Disease Control and Prevention and other places
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Publications (18)
A real-time reverse transcription polymerase chain reaction (RT-qPCR) assay that does not require Emergency Use Authorization (EUA) reagents was tested and validated for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the early stages of the outbreak of coronavirus disease 2019 (COVID-19) in the Republic of Kore...
The South Korean government effectively contained the coronavirus disease-2019 (COVID-19) outbreak primarily associated with a religious group. We conducted SARS-CoV-2 whole genome sequencing of 66 cases to investigate connections among the initial South Korean cases and the religious group outbreak. We assessed the accuracy of genomic investigatio...
The risk of polio importation and re-emergence persists since epidemic polio still occurs in some countries, and the resurgence of polio occurring almost 20 years after polio eradication was declared in Asia has been reported. We analyzed the results of acute flaccid paralysis (AFP) surveillance in Korea to assess the quality of AFP surveillance an...
Since a novel beta-coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019, there has been a rapid global spread of the virus. Genomic surveillance was conducted on samples isolated from infected individuals to monitor the spread of genetic variants of SARS-CoV-2 in Korea. The Korea Disease Cont...
Hepatitis A, an acute type of hepatitis caused by the hepatitis A virus, occurs worldwide. Following the 2009 hepatitis A epidemic in South Korea, patient outbreak reports were collectively converted to an "all-patient report" in 2011, and national immunization programs were introduced for children in 2015. In this study, we aimed to analyze the ch...
Contaminated salted shellfish were a suspected cause of the 2019 hepatitis A outbreak in Korea; however, no virus was detected in the shellfish by the virus detection tests used. In this study, we investigated the shortcomings of these detection tests for identifying hepatitis A virus in salted shellfish to serve as a guide for improvement of these...
Background: Compared to influenza virus and respiratory syncytial virus, common human coronaviruses (HCoVs) are relatively understudied due to the mild nature of HCoV infection. Given the lack of local epidemiology data on common HCoVs in Korea, we aimed to describe epidemiological characteristics of common HCoVs.
Methods: Respiratory viral test re...
Background: A real-time reverse transcription polymerase chain reaction (RT-PCR) assay for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was developed to rapidly diagnose coronavirus disease 2019 (COVID-19). Early diagnosis of COVID-19 enables timely treatment and the implementation of public health measures. We validated t...
Acute gastroenteritis is a global public health concern. This study aimed to analyze the trend and characteristics of acute viral gastroenteritis through a national surveillance network. Enteric viruses were detected in 9,510 of 31,750 (30.1%) cases assessed from 2013–2019 by EnterNet. The most prevalent pathogens were norovirus (15.2%) and group A...
Background
Enteroviruses (EVs) occur frequently worldwide and are known to be associated with a broad spectrum of clinical manifestations from mild syndromes to neurological disease. To understand the epidemiology of EV in Korea, we characterized EV-infected cases during 2012–2019 based on national surveillance.
Methods
We collected specimens from...
Objectives:
The Korea Centers for Disease Control and Prevention has published "A Guideline for Unknown Disease Outbreaks (UDO)." The aim of this report was to introduce tabletop exercises (TTX) to prepare for UDO in the future.
Methods:
The UDO Laboratory Analyses Task Force in Korea Centers for Disease Control and Prevention in April 2018, ass...
The South Korean government effectively contained the coronavirus disease-2019 (COVID-19) outbreak primarily associated with the Shincheonji religious group. We conducted SARS-CoV-2 whole genome sequencing of 66 cases to investigate connections among the initial South Korean cases and the Shincheonji outbreak. We assessed the accuracy of genomic in...
The South Korean government effectively contained the coronavirus disease-2019 (COVID-19) outbreak primarily associated with a religious group. We conducted SARS-CoV-2 whole genome sequencing of 66 cases to investigate connections among the initial South Korean cases and the religious group outbreak. We assessed the accuracy of genomic investigatio...
External quality assessment (EQA) is essential for ensuring reliable test results, especially when laboratories are using assays authorized for emergency use for newly emerging pathogens. We developed an EQA panel to assess the quality of real-time reverse transcription PCR assays being used in South Korea to detect severe acute respiratory syndrom...
Objectives:
Coronavirus Disease-19 (COVID-19) is a respiratory infection characterized by the main symptoms of pneumonia and fever. It is caused by the novel coronavirus severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), which is known to spread via respiratory droplets. We aimed to determine the rate and likelihood of SARS-CoV-2 transm...
Objectives:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019 and has been rapidly spreading worldwide. Although the causal relationship among mutations and the features of SARS-CoV-2 such as rapid transmission, pathogenicity, and tropism, remains unclear, our results of genomic mutations in SAR...
As of February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started in China in December 2019 has been spreading in many countries in the world. With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. However, data on viral lo...
Objectives:
Following reports of patients with unexplained pneumonia at the end of December 2019 in Wuhan, China, the causative agent was identified as coronavirus (SARS-CoV-2), and the 2019 novel coronavirus disease was named COVID-19 by the World Health Organization. Putative patients with COVID-19 have been identified in South Korea, and attemp...
Citations
... We thus set the median 11% false-negative rate as default, but consider both the lowest and highest end-points of the reported range, though note that 58% is unrealistically high for the test-result to be meaningful. As for false positives, studies assessing a total of 119 South Korean laboratories (18,19) and 52 Austrian laboratories (20) did not report false positive results, and a study evaluating 365 . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. ...
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... The samples are collected from parts of the body where the coronavirus collects, such as a person's nose or throat. These samples were inserted into the polymerase chain reaction (PCR) tool and used optimal primers and probes to extract RNA from the virus [7], [8]. Based on the extraction/sequencing results, the SARS-CoV-2 genome has a length of 29,891 bp with a frequency of G and C of 38% [9]. ...
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... Likewise, SARS-CoV-2 variants have emerged [3][4][5] and elude the antibodies elicited by the ancestral or founder SARS-CoV-2 strains. Additionally, with the multiple genomic sequence data of the nCoV already available since the clinical trials to produce vaccines against this nCoV [6]. In India, the central drugs standard control organization (CDSCO) has granted the emergency-use authorization [EUA] to three vaccines namely, ...
... In this work we sought to provide insight into RBD mutations using the Global Initiative on Sharing All Influenza Data (GISAID) database 29,30 . Multiple works have characterized the mutational landscape of the full SARS-CoV-2 genome or the S coding sequence using the GISAID database downloaded at various timepoints 27,[31][32][33][34] . SARS-CoV-2 regions with high mutation frequency have been shown to include ORF1a, ORF1b, S, ORF3a, and N coding sequences 32 . ...
... The kinetics of viral load is another factor that varies between individuals and is influenced by the patients' epidemiological history, immune response, and treatment or medication effects [46]. It is another factor that can contribute to false-negative results. ...
... Published studies shed little light on viremia due to SARS CoV-2, and the available literature reports rates between 2.8 per cent to 15 per cent (Kim et al. 2020;Huang et al. 2020). However these reported intermittent viremia in blood. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/790648059879426-1565516595486_Q64/Heui-Kim.jpg)
... The hepatitis A virus (HAV) is one of the major causes of acute hepatitis [1][2][3], sometimes resulting in acute liver failure, leading to a transplant or even death [3,4]. Although a vaccine for HAV infection has been achieved, gaining access to vaccinations may be difficult in low-and middle-income countries due to the associated high costs or ethical problems [5,6]. ...
... Viral RNA was extracted from the specimens using a QIAamp viral RNA Mini Kit (Qiagen, Hilden, Germany) according to the manufacturer's instructions. One-step realtime reverse transcription polymerase chain reaction (RT-PCR) was performed using a 2X qScript XLT one-step quantitative RT-PCR (RT-qPCR) Toughmix (Quanta Biosciences, Beverly, MA, USA) and the pan-enterovirus specificity primer and probe [8]. The conventional RT-PCR for the amplification of the enterovirus (EV) VP1 region was performed by using an EV VP1 detection kit (iNtRon Biotechnology, Gyeonggi, Korea). ...
