Morgan Barth's research while affiliated with Pennsylvania State University and other places

Publication (1)

Article
Recent advances in cell culture technology have created significant pressure on the downstream purification process, leading to a "downstream bottleneck" in the production of recombinant therapeutic proteins for the treatment of cancer, genetic disorders, and cardiovascular disease. Countercurrent tangential chromatography overcomes many of the lim...

Citations

... However, this process has not been used in large-scale manufacturing of mAbs [38,39]. In recent years, several continuous or semi-continuous methods have been developed for primary capture including periodic counter-current chromatography (PCC) [40], multi-column countercurrent solvent gradient purification (MCSGP) [9,28], continuous countercurrent tangential chromatography (CCTC) [9,28,[41][42][43][44], and continuous precipitation process [18]. ATPS can also be modified for continuous operation with packed columns [45,46]. ...