Monize Caiado Decarli’s scientific contributions

The biofabrication of engineered tissues is an essential area to reconstruct tissues. Until now, to the best of our knowledge, it has not been possible to mimic the biological and biochemical properties. New approaches to developing a new tissue become an attractive target for bioprinting, which is emerging as an essential strategy to recreate the histoarchitecture and the relationship between cells, matrix, and microenvironment. Simulation in a microscale study is a crucial factor to understand specifics physical phenomena and how they affect biological tissue formation. The objective of this paper is to analyze the behavior of the stress on the hierarchical layers of the cartilage using finite element method. The interaction of the collagen fibers with the chondrocyte was observed through the contact regions of the Minimum Principal Stress (compression) analysis accompanied by deformation results. The boundary conditions were applied to a standard 50 μm edge cube with a perpendicular pressure of 4.5*10-5 MPa. The results are promising for future simulations of more detailed models with bias in vivo and in vitro. DOI: https:/doi.org/10.24243/JMEB/3.5.199 2019. Published by Rational Publication.

The goal is to analyze the impact of stress on the hierarchical layers of the cartilage using finite element method. his work presents an approach that allows predicting the behavior of biological processes such as angiogenesis, molecules diffusion and cells interactions, besides to provide a new outlook in the biofabrication of tissues and organs.

The biofabrication of engineered tissues is an essential area to reconstruct tissues. Until now, to the best of our knowledge, it has not been possible to mimic the biological and biochemical properties. New approaches to developing a new tissue become an attractive target for bioprinting, which is emerging as an essential strategy to recreate the histoarchitecture and the relationship between cells, matrix, and microenvironment. Simulations in a microscale study is a crucial factor to understand specifics properties. The objective is to analyze the impact of stress on the hierarchical layers of the cartilage using finite element method. The interaction of the collagen fibers with the chondrocyte was observed through the contact regions of the principal minimal stress analysis, mainly in the region of contact between chondrocytes. The deformation corresponds to the condition of constraint and applied force. The results are promising for future simulations of more detailed models with bias in vivo and in vitro.

O que é Biofabricação de órgãos? A construção automatizada de produtos biologicamente funcionais com organização estrutural de células vivas, biomoléculas, biomateriais e agregados celulares, por meio da bioimpressão 3D e subsequente maturação em biorreatores. Objetivos • Produzir microtecidos e organoides para testes e desenvolvimento de drogas; • Reduzir ou evitar o uso de animais em laboratório; • Produzir tecidos e órgãos para reduzir ou extinguir a fila de transplantes.

3D bioprinting process can be adapted to produce tissues in a variety of shapes, structural complexities. In recent years, in silico approach has been prac­ticed in several fields, and offers new opportunities for medical investigation and discovery, helping and improving the generation of new data and the storage, organization, and classification of the large data sets of digital biological information that is available. This work presents an approach that allows predicting the behavior of biological processes such as angiogenesis, molecules diffusion, and cells interactions, besides to provide a new outlook in the biofabrication of tissues and organs