Monique Verschuren's research while affiliated with University Medical Center Utrecht and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (38)
Objectives
To investigate the contribution of behavioural, social and psychological factors to inequalities in mortality by educational level between birth cohorts.
Design
Cohort-sequential design.
Setting
Two population-based studies in the Netherlands: the Longitudinal Aging Study Amsterdam (LASA) and the Doetinchem Cohort Study (DCS).
Partici...
This study explores whether sex differences in the sensitivity to risk factors (strength of the association) and/or in the exposure to risk factors (prevalence) contributes to the sex difference in physical functioning, with women reporting more limitations. Data of the Doetinchem Cohort Study was used (n=5971, initial ages 26-70 years), with follo...
This study explores whether a sex difference in sensitivity to (strength of the association) and/or in exposure to (prevalence) determinants of gait speed contributes to the observed lower gait speed among women compared to men. Data from the Longitudinal Aging Study Amsterdam (LASA) were used. In total 2407 men and women aged 55-81 years were incl...
Background
Long-term exposure to outdoor air pollution increases the risk of cardiovascular disease, but evidence is unclear on the health effects of exposure to pollutant concentrations lower than current EU and US standards and WHO guideline limits. Within the multicentre study Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we in...
Pooling metabolomics data across studies is often desirable to increase the statistical power of the analysis. However, this can raise methodological challenges as several preanalytical and analytical factors could introduce differences in measured concentrations and variability between datasets. Specifically, different studies may use variable sam...
Background
White cell count (WCC) is a clinical marker of inflammation. Data are limited regarding the association of total and differential WCC with risk of mortality, and its role related with smoking and body mass index (BMI).
Methods
A total of 14 433 participants (4150 men; 10 283 women; average age 47.3±11.8 years) from the Dutch European Pr...
Background:
Obesity is an established risk factor for several common chronic diseases such as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the biological basis for these relationships is not fully understood. To explore the association of obesity with these conditions, we investigated peripheral blood leucocyte (PB...
Background:
Several modifiable risk factors for cognitive decline have been identified, but whether differences by gender and educational level exist is unclear.
Objective:
The present study aims to clarify this by prospectively investigating the relationship between health and lifestyle factors and cognitive functioning in different subgroups d...
Background
Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease.
Methods
We did a c...
Introduction
Shift work has been associated with cardiometabolic risk factors, but the relation is not clear for all risk factors, and the role of chronotype is largely unknown. We examined associations between shift work and cardiometabolic risk factors, and explored these associations in different chronotypes.
Methods
Risk factors (anthropometry...
Background: A causal link between a low vitamin D status and the development of inflammatory bowel disease (IBD) has previously been suggested. The aim of this study was to investigate the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative coli...
The relationship between aging, health and healthcare expenditures is of central importance to academics and public policy makers. Generally, it is observed that, with advancing age, health deteriorates and healthcare expenditures increase. This seems to imply that increases in life expectancy would strongly increase both the demand for healthcare...
As the current prevalence and incidence estimates of diabetes in The Netherlands date from 2007, the aim was to update the estimates of the prevalence and incidence of diabetes for The Netherlands.
Background:
Diabetes has been defined on the basis of different biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA1c. We assessed the effect of different diagnostic definitions on both the population prevalence of diabetes and the classification of previously undiagnosed indiv...
BACKGROUND:
High blood pressure, blood glucose, serum cholesterol, and BMI are risk factors for cardiovascular diseases and some of these factors also increase the risk of chronic kidney disease and diabetes. We estimated mortality from cardiovascular diseases, chronic kidney disease, and diabetes that was attributable to these four cardiometabolic...
Salutogenese is een benadering die kijkt naar datgene wat mensen gezond maakt en houdt in plaats van alleen naar risicofactoren te kijken. Een belangrijk concept binnen de salutogenese is ‘Sense of Coherence’ (SOC): de mate waarin iemand mogelijkheden ervaart problemen en stressvolle gebeurtenissen te hanteren. Onderzoek toont aan dat een sterke SO...
Country/Centre-specific association between the health behaviour score (highest category, i.e. all three health behaviours) and 5-year waist circumference change (cm) in women. Country or centre specific estimates were calculated using general linear models in centres and countries with one centre only, or multilevel mixed-effects linear regression...
Country/Centre-specific association between the health behaviour score (highest category, i.e. all three health behaviours) and 5-year weight change (kg) in women. Country or centre specific estimates were calculated using general linear models in centres and countries with one centre only, or multilevel mixed-effects linear regression models in co...
Country/Centre-specific association between the health behaviour score (highest category, i.e. all three health behaviours) and 5-year waist circumference change (cm) in men. Country or centre specific estimates were calculated using general linear models in centres and countries with one centre only, or multilevel mixed-effects linear regression m...
Country/Centre-specific association between the health behaviour score (highest category, i.e. all three health behaviours) and 5-year weight change (kg) in men. Country or centre specific estimates were calculated using general linear models in centres and countries with one centre only, or multilevel mixed-effects linear regression models in coun...
The evidence that individual dietary and lifestyle factors influence a person's weight and waist circumference is well established; however their combined impact is less well documented. Therefore, we investigated the combined effect of physical activity, nutrition and smoking status on prospective gain in body weight and waist circumference.
We us...
Overweight and obesity prevalence are commonly used for public and policy communication of the extent of the obesity epidemic, yet comparable estimates of trends in overweight and obesity prevalence by country are not available.
We estimated trends between 1980 and 2008 in overweight and obesity prevalence and their uncertainty for adults 20 years...
Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian random isation can be used to test the...
Cited By (since 1996):2, Export Date: 18 October 2014
Prospective cohort study.
We explored long-term associations between physical load exposure and chronic low back pain (LBP) using data from an ongoing population-based cohort study.
Physical load in work or daily life is often studied in relation to LBP. Most studies are cross-sectional or have a limited follow-up.
Between 1993 and 2007, 4738 men a...
Cardiac patients after an acute event and/or with chronic heart disease deserve special attention to restore their quality of life and to maintain or improve functional capacity. They require counselling to avoid recurrence through a combination of adherence to a medication plan and adoption of a healthy lifestyle. These secondary prevention target...
We attempted to quantify the burden of cardiovascular disease that can be prevented by broader adherence to recommendations on dietary intake of key nutrients.
A computer model capturing the epidemiology of chronic disease and risk factors in the Dutch population was used to simulate differences in the occurrence of cardiovascular disease under var...
A major scientific challenge for the next few decades is to understand the interaction between genetic sus-ceptibility and environmental factors in the aetiology of chronic diseases. The most promising approach to discover these interactions requires a combined effort of epidemiology and molecular genetics and large sample sizes for sufficient powe...
Scheltens T, Grobbee DE, Kok L, Verschuren WMM, Bots ML, Numans ME, Hoes AW. From the NHG Cholesterol Standard to the NHG Cardiovascular Risk Management Standard: what happens now? Huisarts Wet 2008;51(9): 420-5.
Background Prevention of cardiovascular diseases (CVD) by detection and treatment of subjects at high risk for these diseases is the reco...
Citations
... Blood pressure (BP) control improves cardiovascular (CV) outcomes [4,5]. High BP is the single leading risk factor for health loss and premature death worldwide. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272339694780421-1441942251170_Q64/Joep-Perk.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/279000929849398-1443530413524_Q64/Guy-De-Backer-2.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/371030532083713-1465471980242_Q64/Ian-Graham-8.jpg)
... [2][3][4] As contemporary studies expand the diversity of participants to be more reflective of the US population, there is accumulating evidence demonstrating that HDL-C's associations are nonlinear and blunted with respect to myocardial infarction (MI), stroke, and all-cause mortality. [5][6][7][8] This is underscored by failure of novel drugs that robustly increase HDL-C to affect incidence of MI and ischemic stroke, 9 further supporting the disconnection between HDL-C and ASCVD. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272317792124934-1441937029698_Q64/Benjamin-Voight.jpg)
... The mean PM2.5 concentration in our dataset was 9.9919 µg/m 3 , with a standard deviation of 1.057 µg/m 3 . The current limit values for PM2.5 set by the European Union and the United States Environmental Protection Agency are 25 µg/m 3 and 12 µg/m 3 , respectively, which are higher than the threshold utilized in our study 9 . ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/612342706475010-1523005286533_Q64/Zorana-Andersen.jpg)
... When studying the association between leukocytosis and mortality, it was found that, similar to our results, a study conducted by Abete et al. (2019) in the Netherlands reported that white blood count could be used as a prediagnostic factor associated with the risk of all-cause mortality in critically ill patients [41]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272422238683136-1441961931016_Q64/Itziar-Abete.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1005574053457922-1616758945730_Q64/Camille-Lassale.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272193410039856-1441907374891_Q64/Hbas-Bueno-De-Mesquita.jpg)
... LIBRA summarized 12 modifiable or manageable dementia risk factors in a weighted sum score, with weights based on a factor's relative risk in metaanalyses [4]. It has been used in different prospective cohorts and multifactorial trails for prediction of cognitive decline and dementia [27][28][29][30][31][32][33][34]. Questionnaires, anthropomorphic measures, and clinical information were used to assess presence of 11 risk and protective factors. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/314457064968192-1451983814209_Q64/Kay-Deckers.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/279829673988103-1443728001659_Q64/Martin-Boxtel.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272455147192337-1441969777457_Q64/Frans-Verhey-2.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/528086649106433-1502917076360_Q64/Sebastian-Koehler-2.jpg)
... Disease progression bias is thus a form of reverse causation. It results in a lack of etiologic significance of the disease-altered exposure biomarkers (Porta et al. 2007;Porta et al. 2008;Porta et al. 2009;Porta et al. 2014;Porta et al. 2005;Porta et al. 2021;Porta 2001;Gasull et al. 2019). This conceptual and empirical framework provides the rationale to hypothesize that pancreatic cancer progression might also modify concentrations of trace elements in toenails (Gómez-Tomás et al. 2019;Camargo et al. 2019;Amaral et al. 2012;Crous-Bou 2009). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/280106246393866-1443793941500_Q64/Panu-Rantakokko.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272346879623202-1441943964863_Q64/Miquel-Porta-2.jpg)
... The temporal sequence between epigenetic changes and onset of childhood obesity is uncertain, however as observed in adults, the available evidence suggests DNA methylation changes are a consequence of adiposity rather than a cause (Sun et al, 2019;Wahl et al, 2017). If obesity causes epigenetic changes, then epigenetics may fall on the causal pathway between obesity and obesity related outcomes, as already suggested in previous children (Reed et al, 2020) and adult studies (Campanella et al., 2018). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/291641614192642-1446544187870_Q64/Silvia-Polidoro.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/278768263417860-1443474941231_Q64/Vittorio-Krogh.jpg)
... Európában 1 ital 10 g, az Egyesült Államokban 14 g alkoholnak felel meg [5,6]. Az Amerikai Májkutatási Társaság (AASLD) irányelve szerint nők számára napi 1, férfiak számára napi 2 ital fogyasztása megengedhető [5], bár az irodalom ban szerepel olyan adat is, miszerint a nem ártalmas alko holdózis nők és férfiak esetén is a napi 1 ital [7]. ...
Reference: Alkoholos májbetegség – 2023
![[object Object]](https://i1.rgstatic.net/ii/profile.image/428478551072769-1479168655886_Q64/Peter-Willeit.jpg)
... Vitamin D is an immunomodulator, and growing evidence shows that IBD patients may benefit from vitamin D treatment [134]. Large cohort studies indicate that vitamin D deficiency may predispose to the development of CD, although this was not reproduced in a pan-European nested case-control study [135]. In patients with established CD, vitamin D deficiency is associated with disease activity in patients [136][137][138] and impaired quality of life [139,140]. ...
... Vitamin D has influence on inflamed intestinal mucosa and several studies have demonstrated a latitude-dependent prevalence [9] and incidence of inflammatory bowel disease (IBD) [10,11]. On the other hand, a recent pan-European nested case-control found no association between development of IBD and vitamin D status [12]. Randomised placebo-controlled trials of intermediate-dose vitamin D supplementation in patients with Crohn's disease have demonstrated decreased relapse rate [13], maintained intestinal permeability and increased plasma levels of the antimicrobial peptide cathelicidin [14], suggesting an immune regulating effect in IBD. ...
