Monica Varun Tyagi's research while affiliated with Stanford University and other places

Publications (4)

Article
Background: Genetic testing for germline pheochromocytoma and paraganglioma susceptibility genes is associated with improved patient management. However, data are currently sparse on the probability of a positive testing result based on an individual's clinical presentation. This study evaluates clinical characteristics for association with testin...
Article
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Recent evidence has implicated APOBEC3B (Apolipoprotein B mRNA editing enzyme catalytic subunit 3B) as a source of mutations in breast, bladder, cervical, lung, head, and neck cancers. However, the role of APOBEC3B in adrenocortical carcinoma (ACC) and the mechanisms through which its expression is regulated in cancer are not fully understood. Here...
Article
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The aim of this study is to determine the accuracy of adrenal vein sampling (AVS) with and without adrenocorticotropic hormone (ACTH) stimulation to distinguish between unilateral and bilateral primary hyperaldosteronism (PA). Retrospective analysis of a prospective database from a referral center between 1984 and 2009, 76 patients had simultaneous...
Article
Full-text available
Background Aberrant methylation is a known cause of cancer initiation and/or progression. There are scant data on the genome‐wide methylation pattern of nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) and sporadic and hereditary NFPanNETs. Methods Thirty‐three tissue samples were analyzed: they included samples from sporadic (n = 9), v...

Citations

... Although deregulation of APOBEC3B has been reported in many cancer types, the conclusions about the prognostic value of A3B for patients remain controversial. A large number of studies reported that high A3B expression is linked with adverse outcomes or poor prognosis in cancer patients [40,[42][43][44]. However, several studies reported that A3B expression improved OS in patients with cancer or have no correlations with disease-free or overall survival [32,45,46]. ...
... Some centers use unilateral sequential sampling, while others use simultaneous bilateral sampling [12]. Different centers perform AVS with or without ACTH stimulation [13,14]. There are no specific guidelines or recommendations regarding whether ACTH stimulation is necessary [15,16]. ...
... Furthermore, MEN1-related PanNETs likewise have a high rate of promoter and genome-wide hypermethylation that is considered a distinctive feature of MEN1-related neoplasms [12,65]. In addition, MEN1 deficiency was reported to be associated with CpG hypermethylation contrary to sporadic or VHL-associated PanNETs [70]. These findings support the role of DNA methylation in PanNETs as being influenced by MEN1 mutations and may explain why MEN1 syndrome has inconsistent genotype-phenotype relationships [71]. ...